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Protein Overview: pik3

General Information:
Name(s) found: pik3 / SPAC458.05 [Sanger Pombe]
Description(s) found:
Found 17 descriptions.
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  • phosphatidylinositol 3-kinase Pik3 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 801 amino acids

    Gene Ontology:
    Cellular Component: phosphoinositide 3-kinase complex [ICLink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: vesicle-mediated transport [TASLink to PubMed article]
    vacuole organization [IMPLink to PubMed article]
    phosphoinositide-mediated signaling [IEA]
    ascospore-type prospore formation [IMPLink to PubMed article]
    phosphoinositide phosphorylation [IEA]
    phosphatidylinositol metabolic process [IGILink to PubMed article]
    ascospore wall assembly [IMPLink to PubMed article]
    cellular protein localization [IGILink to PubMed article]
    Molecular Function: ATP binding [IEA]
    1-phosphatidylinositol-3-kinase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDRLVFSYCP SSKVTARFLV KFCFIEYQDS QEPCICTIQL FSGNESGSLM QKCFVSKIPN  60
   61 KSLLPTELSK ISTHEWLDFG VTVSELSLNA KFVVSAWKPS FNDEEVYEFV GCTTYRLFDE 120
  121 NNLLRQGLQK IPLQTSKEIK KYSPTSLELE QVKEINRLDG LLLKLQLGDV PSVNWLDDIS 180
  181 FGKIKDFRSK HMSLVTIPIL YLDFLQFSFP VVFQRSYYPK SENRVYYSSF DLELNLDSPA 240
  241 ELKHRRLVRS QRNGPLDKDL KPNSKIRKEL ESILSYPPSE ELSLEEKDLI WKFRFYLTRN 300
  301 KKAMTKFLKS VVWTDSSEVN QALSLLDSWT EIDIDDALEL LSPSFVHPKV RAYAVSRLET 360
  361 ASNEELLLYL LQLVQALRYD NPISSDERFQ PSPLALFLVN RAISSPSIGN DLYWYLVVEI 420
  421 EDEPVSKLFS SVMFLFQKEL SKSVEGRLIR ETLSAQAKFV EKLLRISKSV QSFRGTRLKK 480
  481 IEYLKVLLED HKYHLLDFHA LPLPLDPSVN IVGIIPDACT VFKSTMQPLR LLFKCQDGSK 540
  541 YPIIFKNGDD LRQDQLVIQI LTLMDKLLKK EKLDLHLKPY RILATGPTHG AVQFVPSKTL 600
  601 ATILAEYHGS VLAYLRENNP DDGLNSANYG IDPVAMDNYV RSCAGYCVIT YLLGVGDRHL 660
  661 DNLLITKDGH FFHADFGYIL GRDPKLFSPA MKLSKEMVEG MGGYNSPFYQ QFKSYCYTTF 720
  721 TALRKSSNLI LNLFSLMVDA NIPDIKFDKE KVVYKVKERF CLQMSESDAI KYFEQLINDS 780
  781 VSALFPQIID RMHNLAQYMR S

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..801] PSI-BLAST 163.0 Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 1-phosphatidylinositol-3-kinase activity
    		•  8.12544462052019 bayes_pls_golite062009
  • phosphoinositide 3-kinase activity
    		•  8.10715314025226 bayes_pls_golite062009
  • lipid kinase activity
    		•  5.98454599133418 bayes_pls_golite062009
  • inositol or phosphatidylinositol kinase activity
    		•  5.59422890717019 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • protein kinase activity
    		•  5.17195961442593 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate 3-kinase activity
    		•  4.51744163880238 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • calcium-dependent phospholipid binding
    		•  2.37116581763683 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.36057410204148 bayes_pls_golite062009
  • binding
    		•  2.31930216202447 bayes_pls_golite062009
  • profilin binding
    		•  2.1052288288978 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.97522797979421 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.95775692939268 bayes_pls_golite062009
  • signal transducer activity
    		•  1.95775692939268 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.63027742934354 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  1.4515576307774 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • neurexin binding
    		•  1.37902741014529 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.27941426224024 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  1.27740808551012 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • receptor activity
    		•  1.13726344123824 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.96468055729151 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.58590430118616 bayes_pls_golite062009
  • signal sequence binding
    		•  0.57106697498903 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.5066845540941 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.451090007290896 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • clathrin binding
    		•  0.35775052108553 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • protein complex binding
    		•  0.265979208658691 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.252495966234234 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.205652638854091 bayes_pls_golite062009
  • nuclear localization sequence binding
    		•  0.200784507667389 bayes_pls_golite062009
  • hydrolase activity
    		•  0.056449407710228 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.00492507437049428 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
  • protein tag
    		•  0.00311613478935058 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.83

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle