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Protein Overview: psm1

General Information:
Name(s) found: psm1 / SPBC29A10.04 [Sanger Pombe]
Description(s) found:
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  • pir||T40059 chromosome segregation protein smc1 SPBC29A10.04 [similarity] - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|4007792|emb|CAA22432.1| mitotic cohesin complex subunit Psm1 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|27734444|sp|O94383.1|SMC1_SCHPO RecName: Full=Structural maintenance of chromosomes protein 1; AltName: Full=Chromosome segregation protein smc1; AltName: Full=Cohesin complex subunit psm1 [NCBI NR]
  • gi|19112841|ref|NP_596049.1| mitotic cohesin complex subunit Psm1 [Schizosaccharomyces pombe] [NCBI NR]
  • mitotic cohesin complex subunit Psm1 [Sanger Pombe]
  • Structural maintenance of chromosomes protein 1 OS=Schizosaccharomyces pombe GN=psm1 PE=1 SV=1 [Swiss-Prot]
  • COHESIN SUBUNIT; SIMILAR TO S. CEREVISIAE SMC1: O94383; [pompepVF.fasta]
  • XENOPUS 14S COHESIN SMC1 SUBUNIT HOMOLOG: O94383; [pompepV13]
  • Structural maintenance of chromosome 1 (Cohesin complex subunit psm1) (Chromosome segregation protein smc1) [pompep4896]
  • |psm1|smc1|cohesin subunit [pompepnew.fasta]
  • |psm1|smc1|mitotic cohesin complex (subunit) (PMID 11069892)|Schizosaccharomyces pombe|chr 2|||Manual [pombe041504.fasta]
  • Xenopus 14s cohesin smc1 subunit homolog [Schizosaccharomyces pombe]gi|4007792|emb|CAA22432.1| SPBC29A10.04 [Schizosaccharomyces pombe]gi|27734444|sp|O94383|SMC1_SCHPO Structural maintenance of chromosome 1 (Cohesin complex subunit psm1) (Chromosome seg [nrdb_11152004_Chlamydomonas]
  • |psm1|smc1|mitotic cohesin complex |Schizosaccharomyces pombe|chr 2|||Manual [pompep2242005.fasta]
  • (O94383) Structural maintenance of chromosome 1 (Cohesin complex subunit psm1) (Chromosome segregation protein smc1) [pompep4896_normal_reversed]
  • |psm1|smc1|mitotic cohesin complex subunit Psm1|Schizosaccharomyces pombe|chr 2|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • SPBC29A10.04 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPBC29A10.04 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
    • Organism: Schizosaccharomyces pombe
    Length: 1233 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ICLink to PubMed article]
    mitotic cohesin complex [TASLink to PubMed article]
    Biological Process: mitotic sister chromatid cohesion [IMPLink to PubMed article]
    Molecular Function: ATP binding [IEA]
    protein binding [IPILink to PubMed article]
    protein heterodimerization activity [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGRLLRLEVE NFKSYRGHQI IGPFEDFTSI IGPNGAGKSN LMDAISFVLG VKSSHLRSTN  60
   61 VKELIYRGKI LQRDNTDFTD SSNPTTAYVK LMYELDNGEQ REYKRAITPS GATEYKIDEE 120
  121 IVTFSEYCGS LQKENILVRA RNFLVFQGDV ETIASQSPLE LSKLVEQISG SLEYKSEYDK 180
  181 SKDEQDKAVN LSAHSFNKKR GINAELRQYQ EQKTEAERYQ SQKEKRDSAQ LVYLLWKLFH 240
  241 LEKSISSNMA EVTRLKADSI QLIERRDENT KEIEKLKEKE GSIRRNLLAF DRKVRKQEKL 300
  301 IASKRPELIS IAEKALESKS NLRKIQRKAA EIEKDYSDQA STLQVLENQL TSLSAAEKEF 360
  361 LKDMQEKEQL KGLRLLPEDK EEYEGLRSEA DKLNSNLLFK LQTLNRNIKV TSQSKDSLTS 420
  421 IVGDLESKIK SLHESVSSLD TERADLLAKI NEKIESLELE KHDQQKKRLT YSELFHKTQE 480
  481 LNEELQSCLQ KILEASADRN ESKQDAKKRE ALYALKRIYP EVKGRIIDLC TPTQKKYESA 540
  541 IAAALGKNFD AIVVETQAVA KECIDYIKEQ RIGIMTFFPM DTIAASPVNQ KFRGTHKGAR 600
  601 LAIDVLNFES EYERVMISAV GNTLICDSMT VARDLSYNKR LNAKTVTLEG TVIHKTGLIT 660
  661 GGSSNNRSAK HWDDHDFDLL TQTKDRLMHQ IGEIEYQKSS CVITESDTVK LHSLESEISL 720
  721 LKDKYTVVSR SVEDKKKEIG HYESLIKEKQ PHLSELEMEL RNFVKSRDEL QIQVEKVEEK 780
  781 IFSGFCKRIG ISDIHTYDEI HRTFTQSFTQ KQLEFTKQKS LLENRISFEK QRVSDTRLRL 840
  841 ERMHKFIEKD QESIDNYEQN REALESEVAT AEAELELLKE DFASENSKTE KILLAASEKK 900
  901 LVGKRLVSEL TKLSGNITLL ESEIDRYVSE WHAILRKCKL EDIDVPLREG SLTSIPIDDV 960
  961 SNSGDITMGE EPSEPVINFE KFGVEVDYDE LDEELRNDGS ESMASVLQEK LREYSEELDQ1020
 1021 MSPNLRAIER LETVETRLAK LDEEFAAARK AAKNAKERFN AVKQKRLQKF QAAFSHISEQ1080
 1081 IDPIYKELTK SPAFPLGGTA YLTLDDLDEP YLGGIKFHAM PPMKRFRDMD QLSGGEKTMA1140
 1141 ALALLFAIHS YQPSPFFVLD EIDAALDQTN VTKIANYIRQ HASSGFQFVV ISLKNQLFSK1200
 1201 SEALVGIYRD QQENSSRTLS INVRDYFFLI LKY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..379] PSI-BLAST 27.30103 Sc Smc1hd:Scc1-C complex, ATPgS
    2 View Details [380..441] deduced N/A No confident structure predictions are available.
    3 View Details [442..686] FFAS03 4.85 Smc hinge domain
    4 View Details [687..996] FFAS03 2.05 Tropomyosin
    5 View Details [997..1059] deduced N/A No confident structure predictions are available.
    6 View Details [1060..1233] PSI-BLAST 11.69897 Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • motor activity
    		•  2.79327761685782 bayes_pls_golite062009
  • microtubule motor activity
    		•  2.74365461017633 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  2.72462789867829 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • DNA helicase activity
    		•  2.2817164193758 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.16381244011837 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.13284212711072 bayes_pls_golite062009
  • bubble DNA binding
    		•  2.11656807287934 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.11265775498161 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.11046854230259 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  1.88455339138556 bayes_pls_golite062009
    		• 1.75135117904448 bayes_pls_golite062009
  • helicase activity
    		•  1.70242731830224 bayes_pls_golite062009
  • hydrolase activity
    		•  1.66122526893602 bayes_pls_golite062009
  • ATPase activity
    		•  1.53315090215319 bayes_pls_golite062009
  • RNA helicase activity
    		•  1.42791449104435 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.41477043612798 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.40488517180956 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  1.39335733374328 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  1.36724390116598 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  1.29640539057136 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.2539059700735 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.21658213854831 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.21652144153182 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.21571071905795 bayes_pls_golite062009
  • nucleotide binding
    		•  1.20347573865566 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • DNA clamp loader activity
    		•  1.12431517057397 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.117585097627 bayes_pls_golite062009
  • DNA binding
    		•  1.11699929651302 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.989226939888218 bayes_pls_golite062009
  • tubulin binding
    		•  0.979946830272106 bayes_pls_golite062009
  • microtubule binding
    		•  0.907162506177187 bayes_pls_golite062009
  • recombinase activity
    		•  0.88721523495679 bayes_pls_golite062009
  • actin binding
    		•  0.883285269827407 bayes_pls_golite062009
  • RNA binding
    		•  0.715902454627085 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.568457189190858 bayes_pls_golite062009
  • kinetochore binding
    		•  0.534490088080411 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.388587892299301 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.372638007722845 bayes_pls_golite062009
  • GTP binding
    		•  0.364508542344128 bayes_pls_golite062009
  • centromeric DNA binding
    		•  0.322818640526369 bayes_pls_golite062009
  • mismatched DNA binding
    		•  0.31144582840038 bayes_pls_golite062009
  • GTPase activity
    		•  0.234351968078991 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • dynein binding
    		•  0.150959629961177 bayes_pls_golite062009
  • 3'-5' DNA helicase activity
    		•  0.0769112340058804 bayes_pls_golite062009
  • transcription factor activity
    		•  0.0434163635422169 bayes_pls_golite062009
  • microfilament motor activity
    		•  0.0313060889304495 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.91859588671053 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.23709457794394 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.16063754070957 bayes_pls_golite062009
  • DNA binding
    		•  1.10832034923143 bayes_pls_golite062009
  • protein binding
    		•  1.02696508439754 bayes_pls_golite062009
  • DNA secondary structure binding
    		•  1.02239440262162 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.999818859536395 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.558475595998159 bayes_pls_golite062009
  • catalytic activity
    		•  0.265320175609019 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.108132520107784 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle