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Protein Overview: nak1

General Information:
Name(s) found: nak1 / SPBC17F3.02 [Sanger Pombe]
Description(s) found:
Found 20 descriptions.
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  • PAK-related kinase Nak1 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 652 amino acids

    Gene Ontology:
    Cellular Component: medial cortex [TASLink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    cell cortex of cell tip [TASLink to PubMed article]
    spindle pole body [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    actin cortical patch [TASLink to PubMed article]
    Biological Process: regulation of cell shape [IGILink to PubMed article]
    regulation of cell separation during cytokinesis [IMPLink to PubMed article]
    establishment or maintenance of cell polarity [IMPLink to PubMed article]
    cytokinetic cell separation [IGILink to PubMed article]
    protein amino acid phosphorylation [TASLink to PubMed article]
    maintenance of cell polarity [TASLink to PubMed article]
    cellular response to stress [IGILink to PubMed article]
    regulation of bipolar cell growth [IGILink to PubMed article]
    actin filament reorganization involved in cell cycle [IMPLink to PubMed article]
    establishment or maintenance of actin cytoskeleton polarity [IMPLink to PubMed article]
    actin cortical patch localization [IMPLink to PubMed article]
    cellular protein localization [IGILink to PubMed articleLink to PubMed article]
    regulation of monopolar cell growth [IGILink to PubMed article]
    Molecular Function: ATP binding [ICLink to PubMed article]
    protein binding [IPILink to PubMed articleLink to PubMed article]
    protein serine/threonine kinase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MENNTASSPY TKLELVGRGS YGAVYRGICN LTKETVAIKI LNLDTDEDEV SDIQKEVAVL  60
   61 SELKQSDVEN IIKYHGSYLV GTNLWIIMDY CHGGSVRTLM EAGPISEPCI SLILRETLQA 120
  121 LKFIHHAGII HRDIKAANIL VSMSGNVKLC DFGVAAELNI NRRKRITFIG TPYWMAPEVI 180
  181 RDGQEYNVMA DIWSLGITAY EIATGSPPHA KEDPFRAVYL IAHTAPPRLN GNFSALLKEF 240
  241 IASCLQDVPQ RRLDSSELLK SKFIKQYSRM SISELTNVVK RYDTWQAAGG IPQTLLLGEE 300
  301 ADDGSDPDQE TSDTAASDDG WEFGTIKQGQ SNVSSITGTS TSTTTAATSS TTVTGTVIPK 360
  361 SSTVHEPPSS NDSHPLLQLF KDSKISDDDS PSNAEGASTE DSKGEVSYSQ IELPSLDSSN 420
  421 LSSKKSTIQS KHTKQAEDYD LFVGRTRSNS KTSSDQSIKR PLPRVVQRQK TSLGKRGISM 480
  481 SPMKPGLRMP SSFDLQSRSI SMGAFEQLST PLEAPAHKHS AVLQPLEVNR SISIPPPKSI 540
  541 SPSILHKPSL ESASSTPKIS SCSSTPKPFN SKLRAHLPPL SIGSPAVQPL ANDNYDSLGV 600
  601 RGLNMELFND YPGNMHNIKS VLSLEIDIVL GEMDACLKSL ECNLLNRKAY NE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..298] PSI-BLAST 62.69897 No description for 2j51A was found.
    2 View Details [299..523] deduced N/A No confident structure predictions are available.
    3 View Details [524..652] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  4.62392503670521 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • actin binding
    		•  2.91722352767433 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • actin filament binding
    		•  1.75933904320288 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46547714006072 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  1.42275431028856 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.14496167267281 bayes_pls_golite062009
  • tubulin binding
    		•  1.13686658158825 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • JUN kinase kinase kinase kinase activity
    		•  0.926083992524179 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.767275562047313 bayes_pls_golite062009
  • microtubule binding
    		•  0.734274677384472 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • kinase binding
    		•  0.443916188551908 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.401250804041384 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • protein kinase binding
    		•  0.285611963740145 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • myosin binding
    		•  0.259936573810332 bayes_pls_golite062009
  • transporter activity
    		•  0.187543377461637 bayes_pls_golite062009
  • protein complex binding
    		•  0.132247221889251 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.0413380592707298 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  0.0339299940546054 bayes_pls_golite062009
  • MAP kinase kinase kinase kinase activity
    		•  0.01826424351081 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle