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Protein Overview: SPCC1322.05c

General Information:
Name(s) found: SPCC1322.05c [Sanger Pombe]
Description(s) found:
Found 18 descriptions.
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  • leukotriene A-4 hydrolase [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 612 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][ISSLink to PubMed article]
    cytoplasm [ISSLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: leukotriene biosynthetic process [IEA]
    leukotriene metabolic process [ICLink to PubMed article]
    protein catabolic process [ISSLink to PubMed article]
    lipid metabolic process [ISSLink to PubMed article]
    Molecular Function: zinc ion binding [IEA]
    leukotriene-A4 hydrolase activity [ISSLink to PubMed article]
    aminopeptidase activity [ISSLink to PubMed article]
    epoxide hydrolase activity [ISSLink to PubMed article]
    metallopeptidase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLRLDPSTQ SNYHDVSISK LDWHARIDFD QELLHGKVSF VIQSARVSQA LSHIILDTSY  60
   61 LEIKNVTIND IPTPFRVDKR RGFLGSALHI VPADEIPSSK SCILTILYST TKDCTALQFL 120
  121 KPEQTIGGKF PYVFSECQAI HARSFIPCQD TPSVKVPCTF KIRSKLPVIA SGIPCGTANF 180
  181 CNGSLEYLFE QKNPIPSYLF CILSGDLAST NIGPRSSVYT EPGNLLACKY EFEHDMENFM 240
  241 EAAEQLTLPY CWTRYDFVIL PPSFPYGGME NPNATFATPT LIAGDRSNVN VIAHELAHSW 300
  301 SGNLVTNESW QCFWLNEGMT VFLERKILGR LYGEPTRQFE AIIGWGELEE SVKLLGEDSE 360
  361 YTKLIQNLEG RDPDDAFSTV PYEKGSNFLY EIERVIGGPS VFEPFLPFYF RKFAKSTVNE 420
  421 VKFKHALYEY FSPLGLASKL DSIDWDTWYH APGMPPVKPH FDTTLADPCY KLAESWTNSA 480
  481 KNSDDPSKFS SKDIENWSAG QKSLFLDVVY EAVSFPHNYI KRMGDVYSFA ESKNAELSFR 540
  541 FFKLALKSKY KPLYNTIAER VGSVGRMKFV RPIFRLLNEA DRAFAIETFE KYKHFYHKIC 600
  601 ASQVEKDLGL SE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..612] PSI-BLAST 147.0 Leukotriene A4 hydrolase C-terminal domain; Leukotriene A4 hydrolase N-terminal domain; Leukotriene A4 hydrolase catalytic domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidase activity
    		•  5.33358263548929 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  4.99457783001146 bayes_pls_golite062009
  • endopeptidase activity
    		•  4.16532996235931 bayes_pls_golite062009
  • metallopeptidase activity
    		•  3.94798058866011 bayes_pls_golite062009
  • metalloendopeptidase activity
    		•  3.05952802601629 bayes_pls_golite062009
  • hydrolase activity
    		•  2.55673800115122 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.64539435934931 bayes_pls_golite062009
  • exopeptidase activity
    		•  1.63993432278466 bayes_pls_golite062009
  • binding
    		•  1.56078736789756 bayes_pls_golite062009
  • receptor binding
    		•  1.15741823528763 bayes_pls_golite062009
  • catalytic activity
    		•  0.891187593353827 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.686302227492162 bayes_pls_golite062009
  • DNA binding
    		•  0.564067563573999 bayes_pls_golite062009
  • RNA binding
    		•  0.40024158562931 bayes_pls_golite062009
  • serine hydrolase activity
    		•  0.393080846858665 bayes_pls_golite062009
  • serine-type peptidase activity
    		•  0.374597710524442 bayes_pls_golite062009
  • integrin binding
    		•  0.35834172649072 bayes_pls_golite062009
  • growth factor activity
    		•  0.352343150818166 bayes_pls_golite062009
  • protein binding
    		•  0.278366242068789 bayes_pls_golite062009
  • serine-type endopeptidase activity
    		•  0.252655558968584 bayes_pls_golite062009
  • aminopeptidase activity
    		•  0.21808506596674 bayes_pls_golite062009
  • protein complex binding
    		•  0.134132828555441 bayes_pls_golite062009
  • transcription factor activity
    		•  0.012234449355649 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle