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View Structure Prediction Details

Protein: SPCC1322.05c
Organism: Schizosaccharomyces pombe
Length: 612 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPCC1322.05c.

Description E-value Query
Range
Subject
Range
LKHA4_MOUSE - Leukotriene A-4 hydrolase OS=Mus musculus GN=Lta4h PE=1 SV=4
521.0 [0..6] [608..6]
LKHA4_BOVIN - Leukotriene A-4 hydrolase OS=Bos taurus GN=LTA4H PE=2 SV=3
521.0 [0..5] [608..5]
gi|71795621, gi|... - gi|71795621|ref|NP_001025202.1| leukotriene A4 hydrolase [Rattus norvegicus], gi|71122467|gb|AAH9981...
519.0 [0..6] [608..6]
gi|197100222 - gi|197100222|ref|NP_001124802.1| leukotriene A4 hydrolase [Pongo abelii]
gi|55725952 - gi|55725952|emb|CAH89754.1| hypothetical protein [Pongo abelii]
517.0 [0..5] [608..5]
gi|29726225 - gi|29726225|pdb|1GW6|A Chain A, Structure Of Leukotriene A4 Hydrolase D375n Mutant
516.0 [0..5] [608..4]
gi|73978215 - gi|73978215|ref|XP_539728.2| PREDICTED: similar to Leukotriene A-4 hydrolase (LTA-4 hydrolase) (Leuk...
516.0 [0..5] [608..70]
LKHA4_CHILA - Leukotriene A-4 hydrolase OS=Chinchilla lanigera GN=LTA4H PE=2 SV=3
513.0 [0..17] [608..18]

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Predicted Domain #1
Region A:
Residues: [1-612]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLRLDPSTQ SNYHDVSISK LDWHARIDFD QELLHGKVSF VIQSARVSQA LSHIILDTSY  60
   61 LEIKNVTIND IPTPFRVDKR RGFLGSALHI VPADEIPSSK SCILTILYST TKDCTALQFL 120
  121 KPEQTIGGKF PYVFSECQAI HARSFIPCQD TPSVKVPCTF KIRSKLPVIA SGIPCGTANF 180
  181 CNGSLEYLFE QKNPIPSYLF CILSGDLAST NIGPRSSVYT EPGNLLACKY EFEHDMENFM 240
  241 EAAEQLTLPY CWTRYDFVIL PPSFPYGGME NPNATFATPT LIAGDRSNVN VIAHELAHSW 300
  301 SGNLVTNESW QCFWLNEGMT VFLERKILGR LYGEPTRQFE AIIGWGELEE SVKLLGEDSE 360
  361 YTKLIQNLEG RDPDDAFSTV PYEKGSNFLY EIERVIGGPS VFEPFLPFYF RKFAKSTVNE 420
  421 VKFKHALYEY FSPLGLASKL DSIDWDTWYH APGMPPVKPH FDTTLADPCY KLAESWTNSA 480
  481 KNSDDPSKFS SKDIENWSAG QKSLFLDVVY EAVSFPHNYI KRMGDVYSFA ESKNAELSFR 540
  541 FFKLALKSKY KPLYNTIAER VGSVGRMKFV RPIFRLLNEA DRAFAIETFE KYKHFYHKIC 600
  601 ASQVEKDLGL SE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 147.0
Match: 1gw6A
Description: Leukotriene A4 hydrolase C-terminal domain; Leukotriene A4 hydrolase N-terminal domain; Leukotriene A4 hydrolase catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 5.33358263548929 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 4.99457783001146 bayes_pls_golite062009
endopeptidase activity 4.16532996235931 bayes_pls_golite062009
metallopeptidase activity 3.94798058866011 bayes_pls_golite062009
metalloendopeptidase activity 3.05952802601629 bayes_pls_golite062009
hydrolase activity 2.55673800115122 bayes_pls_golite062009
nucleic acid binding 1.64539435934931 bayes_pls_golite062009
exopeptidase activity 1.63993432278466 bayes_pls_golite062009
binding 1.56078736789756 bayes_pls_golite062009
receptor binding 1.15741823528763 bayes_pls_golite062009
catalytic activity 0.891187593353827 bayes_pls_golite062009
transcription regulator activity 0.686302227492162 bayes_pls_golite062009
DNA binding 0.564067563573999 bayes_pls_golite062009
RNA binding 0.40024158562931 bayes_pls_golite062009
serine hydrolase activity 0.393080846858665 bayes_pls_golite062009
serine-type peptidase activity 0.374597710524442 bayes_pls_golite062009
integrin binding 0.35834172649072 bayes_pls_golite062009
growth factor activity 0.352343150818166 bayes_pls_golite062009
protein binding 0.278366242068789 bayes_pls_golite062009
serine-type endopeptidase activity 0.252655558968584 bayes_pls_golite062009
aminopeptidase activity 0.21808506596674 bayes_pls_golite062009
protein complex binding 0.134132828555441 bayes_pls_golite062009
transcription factor activity 0.012234449355649 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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