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Protein Overview: kin1

General Information:
Name(s) found: kin1 / SPBC4F6.06 [Sanger Pombe]
Description(s) found:
Found 19 descriptions.
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  • microtubule affinity-regulating kinase Kin1 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 891 amino acids

    Gene Ontology:
    Cellular Component: microtubule cytoskeleton [RCALink to PubMed article]
    cytoskeleton [RCALink to PubMed article]
    cell tip [IDALink to PubMed articleLink to PubMed article]
    cell division site [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: establishment or maintenance of cell polarity [IMPLink to PubMed article]
    cellular response to stress [IEPLink to PubMed article]
    establishment or maintenance of actin cytoskeleton polarity [IMPLink to PubMed article]
    protein amino acid phosphorylation [ISSLink to PubMed article]
    regulation of microtubule-based movement [IMPLink to PubMed article]
    cytokinesis, site selection [IMPLink to PubMed article]
    Molecular Function: ATP binding [ISSLink to PubMed article]
    protein serine/threonine kinase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEYRTNNVPV GNETKSAALN ALPKIKISDS PNRHHNLVDA FMQSPSYSTQ PKSAVEPLGL  60
   61 SFSPGYISPS SQSPHHGPVR SPSSRKPLPA SPSRTRDHSL RVPVSGHSYS ADEKPRERRK 120
  121 VIGNYVLGKT IGAGSMGKVK VAHHLKTGEQ FAIKIVTRLH PDITKAKAAA SAEATKAAQS 180
  181 EKNKEIRTVR EAALSTLLRH PYICEARDVY ITNSHYYMVF EFVDGGQMLD YIISHGKLKE 240
  241 KQARKFVRQI GSALSYLHQN SVVHRDLKIE NILISKTGDI KIIDFGLSNL YRRQSRLRTF 300
  301 CGSLYFAAPE LLNAQPYIGP EVDVWSFGIV LYVLVCGKVP FDDQNMSALH AKIKKGTVEY 360
  361 PSYLSSDCKG LLSRMLVTDP LKRATLEEVL NHPWMIRNYE GPPASFAPER SPITLPLDPE 420
  421 IIREMNGFDF GPPEKIVREL TKVISSEAYQ SLAKTGFYSG PNSADKKKSF FEFRIRHAAH 480
  481 DIENPILPSL SMNTDIYDAF HPLISIYYLV SERRVYEKGG NWNRIAKTPV SSVPSSPVQP 540
  541 TSYNRTLPPM PEVVAYKGDE ESPRVSRNTS LARRKPLPDT ESHSPSPSAT SSIKKNPSSI 600
  601 FRRFSSRRKQ NKSSTSTLQI SAPLETSQSP PTPRTKPSHK PPVSYKNKLV TQSAIGRSTS 660
  661 VREGRYAGIS SQMDSLNMDS TGPSASNMAN APPSVRNNRV LNPRGASLGH GRMSTSTTNR 720
  721 QKQILNETMG NPVDKNSTSP SKSTDKLDPI KPVFLKGLFS VSTTSTKSTE SIQRDLIRVM 780
  781 GMLDIEYKEI KGGYACLYKP QGIRTPTKST SVHTRRKPSY GSNSTTDSYG SVPDTVPLDD 840
  841 NGESPASNLA FEIYIVKVPI LSLRGVSFHR ISGNSWQYKT LASRILNELK L

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..404] PSI-BLAST 62.522879 Abl tyrosine kinase, SH3 domain; Abl tyrosine kinase; Abelsone tyrosine kinase (abl)
    2 View Details [405..462] PSI-BLAST 85.522879 Catalytic and ubiqutin-associated domains of MARK2/PAR-1: Wild type
    3 View Details [463..648] deduced N/A No confident structure predictions are available.
    4 View Details [649..749] deduced N/A No confident structure predictions are available.
    5 View Details [750..891] PSI-BLAST 39.69897 Solution structure of kinase associated domain 1 of mouse MAP/microtubule affinity-regulating kinase 3

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • calmodulin-dependent protein kinase activity
    		•  4.31938467136214 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • telethonin binding
    		•  2.27062712605521 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • actin binding
    		•  1.87817875565699 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • JUN kinase kinase kinase activity
    		•  1.41172362253967 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • alpha-actinin binding
    		•  1.38861866085902 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.33740973673697 bayes_pls_golite062009
  • gamma-tubulin binding
    		•  1.28511591054866 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.2323381312171 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.16049201286103 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.959360414036299 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • actin filament binding
    		•  0.794152600084 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • transporter activity
    		•  0.553953601841147 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.51726292539973 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • protein phosphorylated amino acid binding
    		•  0.43808715710519 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.37676337669549 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.08504542461349 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.0611721261859464 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • protein kinase activity
    		•  4.05475891009228 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  4.04751809021925 bayes_pls_golite062009
  • kinase activity
    		•  3.88704262604357 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  3.7974128326421 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  3.55786569314106 bayes_pls_golite062009
  • transferase activity
    		•  2.750643926194 bayes_pls_golite062009
  • binding
    		•  2.41732321506551 bayes_pls_golite062009
  • ATP binding
    		•  1.44435058039859 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.41005152726625 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.38971642420542 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.16863558166547 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.16859376715941 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.15633908642115 bayes_pls_golite062009
  • nucleotide binding
    		•  1.14964488472581 bayes_pls_golite062009
  • AMP-activated protein kinase activity
    		•  1.12923456567012 bayes_pls_golite062009
  • catalytic activity
    		•  0.836142537655721 bayes_pls_golite062009
  • protein binding
    		•  0.704339182896017 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.439688030503848 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle