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View Structure Prediction Details

Protein: kin1
Organism: Schizosaccharomyces pombe
Length: 891 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for kin1.

Description E-value Query
Range
Subject
Range
gi|173410, gi|539075 - pir||A38903 protein kinase 1 - fission yeast (Schizosaccharomyces pombe), gi|173410|gb|AAA63577.1| ...
608.0 [0..1] [891..1]
gi|73964111 - gi|73964111|ref|XP_868650.1| PREDICTED: similar to MAP/microtubule affinity-regulating kinase 3 isof...
541.0 [0..71] [891..2]
gi|114654975 - gi|114654975|ref|XP_001137919.1| PREDICTED: MAP/microtubule affinity-regulating kinase 3 isoform 7 [...
541.0 [0..71] [891..2]
gi|119602218, gi... - gi|15042609|gb|AAK82367.1|AF387637_1 Ser/Thr protein kinase PAR-1A [Homo sapiens], gi|119602218|gb|E...
540.0 [0..71] [891..2]

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Predicted Domain #1
Region A:
Residues: [1-404]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEYRTNNVPV GNETKSAALN ALPKIKISDS PNRHHNLVDA FMQSPSYSTQ PKSAVEPLGL  60
   61 SFSPGYISPS SQSPHHGPVR SPSSRKPLPA SPSRTRDHSL RVPVSGHSYS ADEKPRERRK 120
  121 VIGNYVLGKT IGAGSMGKVK VAHHLKTGEQ FAIKIVTRLH PDITKAKAAA SAEATKAAQS 180
  181 EKNKEIRTVR EAALSTLLRH PYICEARDVY ITNSHYYMVF EFVDGGQMLD YIISHGKLKE 240
  241 KQARKFVRQI GSALSYLHQN SVVHRDLKIE NILISKTGDI KIIDFGLSNL YRRQSRLRTF 300
  301 CGSLYFAAPE LLNAQPYIGP EVDVWSFGIV LYVLVCGKVP FDDQNMSALH AKIKKGTVEY 360
  361 PSYLSSDCKG LLSRMLVTDP LKRATLEEVL NHPWMIRNYE GPPA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.522879
Match: 1opkA
Description: Abl tyrosine kinase, SH3 domain; Abl tyrosine kinase; Abelsone tyrosine kinase (abl)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
calmodulin-dependent protein kinase activity 4.31938467136214 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
telethonin binding 2.27062712605521 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
actin binding 1.87817875565699 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
JUN kinase kinase kinase activity 1.41172362253967 bayes_pls_golite062009
protein tyrosine kinase activity 1.3898059094397 bayes_pls_golite062009
alpha-actinin binding 1.38861866085902 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.38496328649031 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
molecular adaptor activity 1.33740973673697 bayes_pls_golite062009
gamma-tubulin binding 1.28511591054866 bayes_pls_golite062009
receptor signaling protein activity 1.27291233344322 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.2323381312171 bayes_pls_golite062009
protein binding 1.22565748038754 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
nucleic acid binding 1.16049201286103 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.959360414036299 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
actin filament binding 0.794152600084 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
transporter activity 0.553953601841147 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.51726292539973 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
protein phosphorylated amino acid binding 0.43808715710519 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
transmembrane transporter activity 0.37676337669549 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
MAP kinase kinase activity 0.35402045013148 bayes_pls_golite062009
signal transducer activity 0.270054246024761 bayes_pls_golite062009
molecular transducer activity 0.270054246024761 bayes_pls_golite062009
MAP kinase activity 0.08504542461349 bayes_pls_golite062009
substrate-specific transporter activity 0.0611721261859464 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.0556163711947139 bayes_pls_golite062009
transmembrane receptor activity 0.00652065412910241 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [405-462]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SFAPERSPIT LPLDPEIIRE MNGFDFGPPE KIVRELTKVI SSEAYQSLAK TGFYSGPN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 85.522879
Match: 1zmuA
Description: Catalytic and ubiqutin-associated domains of MARK2/PAR-1: Wild type
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [463-648]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SADKKKSFFE FRIRHAAHDI ENPILPSLSM NTDIYDAFHP LISIYYLVSE RRVYEKGGNW  60
   61 NRIAKTPVSS VPSSPVQPTS YNRTLPPMPE VVAYKGDEES PRVSRNTSLA RRKPLPDTES 120
  121 HSPSPSATSS IKKNPSSIFR RFSSRRKQNK SSTSTLQISA PLETSQSPPT PRTKPSHKPP 180
  181 VSYKNK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [649-749]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LVTQSAIGRS TSVREGRYAG ISSQMDSLNM DSTGPSASNM ANAPPSVRNN RVLNPRGASL  60
   61 GHGRMSTSTT NRQKQILNET MGNPVDKNST SPSKSTDKLD P

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [750-891]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKPVFLKGLF SVSTTSTKST ESIQRDLIRV MGMLDIEYKE IKGGYACLYK PQGIRTPTKS  60
   61 TSVHTRRKPS YGSNSTTDSY GSVPDTVPLD DNGESPASNL AFEIYIVKVP ILSLRGVSFH 120
  121 RISGNSWQYK TLASRILNEL KL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.69897
Match: 1ul7A
Description: Solution structure of kinase associated domain 1 of mouse MAP/microtubule affinity-regulating kinase 3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein kinase activity 4.05475891009228 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 4.04751809021925 bayes_pls_golite062009
kinase activity 3.88704262604357 bayes_pls_golite062009
protein serine/threonine kinase activity 3.7974128326421 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 3.55786569314106 bayes_pls_golite062009
transferase activity 2.750643926194 bayes_pls_golite062009
binding 2.41732321506551 bayes_pls_golite062009
ATP binding 1.44435058039859 bayes_pls_golite062009
adenyl ribonucleotide binding 1.41005152726625 bayes_pls_golite062009
adenyl nucleotide binding 1.38971642420542 bayes_pls_golite062009
ribonucleotide binding 1.16863558166547 bayes_pls_golite062009
purine ribonucleotide binding 1.16859376715941 bayes_pls_golite062009
purine nucleotide binding 1.15633908642115 bayes_pls_golite062009
nucleotide binding 1.14964488472581 bayes_pls_golite062009
AMP-activated protein kinase activity 1.12923456567012 bayes_pls_golite062009
catalytic activity 0.836142537655721 bayes_pls_golite062009
protein binding 0.704339182896017 bayes_pls_golite062009
magnesium ion binding 0.439688030503848 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle