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Protein Overview: cmk2

General Information:
Name(s) found: cmk2 / SPAC23A1.06c [Sanger Pombe]
Description(s) found:
Found 17 descriptions.
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  • MAPK-activated protein kinase Cmk2 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 504 amino acids

    Gene Ontology:
    Cellular Component: cell septum [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: DNA replication checkpoint [IMPLink to PubMed article]
    G2/M transition of mitotic cell cycle [IMPLink to PubMed article]
    stress-activated protein kinase signaling pathway [IGILink to PubMed article]
    negative regulation of cell cycle [IMPLink to PubMed article]
    cellular response to oxidative stress [IMPLink to PubMed article]
    protein amino acid phosphorylation [IMPLink to PubMed article]
    regulation of G2/M transition of mitotic cell cycle [IMPLink to PubMed article]
    Molecular Function: ATP binding [IEA]
    calmodulin binding [TASLink to PubMed article]
    protein binding [IPILink to PubMed article]
    calcium ion binding [TASLink to PubMed article]
    calmodulin-dependent protein kinase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSILAGFKNL LKHSKSSKGR SNASKSVDVS VNRDVAAYTE LAAKNVNAGG DEEIRVANYP  60
   61 GLEKYQLIEN LGDGAFSQVY KAYSIDRKEH VAVKVIRKYE MNKKQRQGVF KEVNIMRRVK 120
  121 HKNVVNLFDF VETEDFYHLV MELAEGGELF HQIVNFTYFS ENLARHIIIQ VAEAVKHLHD 180
  181 VCGIVHRDIK PENLLFQPIE YLPSQNYTPP SLEPNKLDEG MFLEGIGAGG IGRILIADFG 240
  241 FSKVVWNSKT ATPCGTVGYA APEIVNDELY SKNVDMWAMG CVLHTMLCGF PPFFDENIKD 300
  301 LASKVVNGEF EFLSPWWDDI SDSAKDLITH LLTVDPRERY DIHQFFQHPW IKGESKMPEN 360
  361 FTYKPKLHGT PGGPKLSLPR SLVSKGEIDI PTTPIKSATH PLLSSYSEPK TPGVSSVHEA 420
  421 MGVAYDIRRL NHLGFSPEQL SKKSMNTGSI KELILDEETT TDDDDYIISS FPLNDTLGSE 480
  481 GKDPFSLNLK ESSLYSRRSA KRVN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..368] PSI-BLAST 61.30103 CALMODULIN-DEPENDENT PROTEIN KINASE FROM RAT
    2 View Details [369..504] PSI-BLAST 9.39794 Association donain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • calmodulin-dependent protein kinase activity
    		•  4.31938467136214 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46547714006072 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • actin binding
    		•  1.33479685165255 bayes_pls_golite062009
  • gamma-tubulin binding
    		•  1.28511591054866 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • telethonin binding
    		•  1.04264263421201 bayes_pls_golite062009
  • transcription activator activity
    		•  0.997272622653026 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.959888295228949 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • transporter activity
    		•  0.553953601841147 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.401250804041384 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.37676337669549 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • actin filament binding
    		•  0.2403700250846 bayes_pls_golite062009
  • alpha-actinin binding
    		•  0.181804774839734 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.08504542461349 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.0611721261859464 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009
    2
    Term Confidence Notes
  • calmodulin-dependent protein kinase activity
    		•  3.94000509496614 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.55860381779056 bayes_pls_golite062009
  • binding
    		•  2.52411158739487 bayes_pls_golite062009
  • protein binding
    		•  2.39288962080451 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.08501421446176 bayes_pls_golite062009
  • protein transporter activity
    		•  2.04189231186227 bayes_pls_golite062009
  • protein kinase activity
    		•  2.00097234177267 bayes_pls_golite062009
  • kinase activity
    		•  1.98914072004853 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.76679232625447 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  1.58752723298412 bayes_pls_golite062009
  • transferase activity
    		•  1.27156008037861 bayes_pls_golite062009
  • transporter activity
    		•  1.24263163723761 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  0.90194348627358 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.693314856519628 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.622032418966072 bayes_pls_golite062009
  • RNA binding
    		•  0.47499792472996 bayes_pls_golite062009
  • structural molecule activity
    		•  0.388035617388367 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.204604542884036 bayes_pls_golite062009
  • mRNA binding
    		•  0.15644148341628 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven protein transmembrane transporter activity
    		•  0.06886025448369 bayes_pls_golite062009
  • macromolecule transmembrane transporter activity
    		•  0.06886025448369 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle