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Any process that modulates the frequency, rate or extent of signaling via a stress-activated protein kinase signaling pathway. The process whereby a signal is conveyed via the transfer of one or more phosphate groups. The process whereby a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. Any process that stops, prevents or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling pathway. A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. Any process that activates or increases the frequency, rate or extent of signaling via the stress-activated protein kinase signaling pathway. A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). A series of molecular signals in which a stress-activated MAP kinase cascade relays one or more of the signals; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase. A series of reactions that occur within the cell, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound. A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: stress-activated protein kinase signaling pathway
Acc: GO:0031098
Aspect: Biological Process
Desc: A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals.
Synonyms:
  • JNK signaling pathway
  • JNK signalling pathway
  • stress-activated protein kinase signalling pathway
  • SAPK signalling pathway
  • SAPK signaling pathway
Proteins in PDR annotated with:
   This term: 17 [Search]
   Term or descendants: 325 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0031098 - stress-activated protein kinase signaling pathway (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle