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Protein Overview: dsk1

General Information:
Name(s) found: dsk1 / SPBC530.14c [Sanger Pombe]
Description(s) found:
Found 16 descriptions.
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  • SR protein-specific kinase Dsk1 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 544 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    cell division site [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    spindle pole body [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: regulation of nuclear mRNA splicing, via spliceosome [IGILink to PubMed article]
    intracellular protein kinase cascade [NASLink to PubMed article]
    protein amino acid phosphorylation [IDALink to PubMed article]
    regulation of mitotic cell cycle [IGILink to PubMed article]
    Molecular Function: ATP binding [IEA]
    protein binding [IPILink to PubMed articleLink to PubMed article]
    protein serine/threonine kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSDGSSLSP KVSQPGHTEI VDHVSEKVIT NGKNVNKKVN AEVDGKSMVE KVKTHEENAE  60
   61 DYHYGGYHPV YIGEEFHHRR YVVERKLGWG HFSTVWLAYD RAAKRRVALK VVRSAEHYRE 120
  121 TSIDEIRILQ KIREGDEKHL GKKHIISLLD YFVHRGPNGA HVCMVFEVLG ENLLSLIQSY 180
  181 GHRGVPVGIV KQIAYQLLIA LDYLHRECGI IHTDLKPENV LICIDQDALQ HIEAPATTSS 240
  241 PTSNTSSSKT RNNTGYTAKA PIIKRGQSVD NSAQERKTFA KNPTKNSKPA GQVIPSSPFT 300
  301 STLSRFPSLE GAVSEISLRD SQKHNSHPNS PFSSGDNSLI LDGVNGSQEP VPKITVKIAD 360
  361 LGNACWTRKH FTNDVQTRQY RSPEVILGCR WGASADCWSF ACIIFELLTG DYLFDPRNGN 420
  421 SYSKEDDHIA QIIELLVNYP KQMALSGKHS RDLFNRRGEL RNIHKLKFWP LKDVLEQKYH 480
  481 FSAELAQQIS DFLSPMLCFD PAKRTNAGYM SNSPWLREVA DPTFKIETTG ATGEDVPGWA 540
  541 TEIR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..270] PSI-BLAST 27.522879 The structure of the yeast SR protein kinase, Sky1p, with bound ADP
    2 View Details [271..544] PSI-BLAST 15.09691 Protein kinase CK2, alpha subunit

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46547714006072 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.30988141770642 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transcription factor activity
    		•  1.18212353139877 bayes_pls_golite062009
  • DNA binding
    		•  1.17130513163489 bayes_pls_golite062009
  • RNA binding
    		•  0.892334734235538 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009
    2
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46547714006072 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.30988141770642 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transcription factor activity
    		•  1.18212353139877 bayes_pls_golite062009
  • DNA binding
    		•  1.17130513163489 bayes_pls_golite062009
  • RNA binding
    		•  0.892334734235538 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle