YRC Public Data Repository - Protein Structure Prediction

Protein:	dsk1
Organism:	Schizosaccharomyces pombe
Length:	544 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for dsk1.

Description	E-value	Query Range	Subject Range
gi\|477055, gi\|398157 - pir\|\|A47726 dis1-suppressing protein kinase dsk1 - fission yeast (Schizosaccharomyces pombe), gi\|3...	245.0	[0..1]	[544..1]
gi\|149209311, gi... - gi\|86196103\|gb\|EAQ70741.1\| hypothetical protein MGCH7_ch7g148 [Magnaporthe grisea 70-15], gi\|1492093...	192.0	[0..4]	[544..140]
gi\|115396672, gi... - gi\|115396672\|ref\|XP_001213975.1\| protein kinase dsk1 [Aspergillus terreus NIH2624], gi\|114193544\|gb\|...	190.0	[0..54]	[544..80]
gi\|169782626 - gi\|169782626\|ref\|XP_001825775.1\| hypothetical protein [Aspergillus oryzae RIB40] gi\|83774519 - gi\|83774519\|dbj\|BAE64642.1\| unnamed protein product [Aspergillus oryzae]	188.0	[0..32]	[544..4]
gi\|66844123, gi\|... - gi\|70981943\|ref\|XP_746500.1\| serine protein kinase Sky1 [Aspergillus fumigatus Af293], gi\|66844123\|g... gi\|159122275 - gi\|159122275\|gb\|EDP47397.1\| serine protein kinase Sky1, putative [Aspergillus fumigatus A1163]	188.0	[0..8]	[544..44]
gi\|119180578, gi... - gi\|90300532\|gb\|EAS30163.1\| hypothetical protein CIMG_08909 [Coccidioides immitis RS], gi\|119180578\|r...	184.0	[0..1]	[544..61]
cek1 - serine /threonine protein kinase Cek1 CEK1_SCHPO - Serine/threonine-protein kinase cek1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cek1 ...	183.0	[0..2]	[539..508]
PK2_DICDI - Protein kinase 2 - Dictyostelium discoideum (Slime mold)	162.0	[0..8]	[272..80]

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Predicted Domain #1

Region A:
Residues: [1-270]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSDGSSLSP KVSQPGHTEI VDHVSEKVIT NGKNVNKKVN AEVDGKSMVE KVKTHEENAE  60
   61 DYHYGGYHPV YIGEEFHHRR YVVERKLGWG HFSTVWLAYD RAAKRRVALK VVRSAEHYRE 120
  121 TSIDEIRILQ KIREGDEKHL GKKHIISLLD YFVHRGPNGA HVCMVFEVLG ENLLSLIQSY 180
  181 GHRGVPVGIV KQIAYQLLIA LDYLHRECGI IHTDLKPENV LICIDQDALQ HIEAPATTSS 240
  241 PTSNTSSSKT RNNTGYTAKA PIIKRGQSVD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	27.522879
Match:	1q8yA
Description:	The structure of the yeast SR protein kinase, Sky1p, with bound ADP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphotransferase activity, alcohol group as acceptor	5.49988294224815	bayes_pls_golite062009
protein kinase activity	5.4586557943719	bayes_pls_golite062009
kinase activity	5.3287080791198	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.96052051118534	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
transferase activity	3.97138602499442	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
nucleic acid binding	1.46547714006072	bayes_pls_golite062009
protein tyrosine kinase activity	1.3898059094397	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.38496328649031	bayes_pls_golite062009
transcription regulator activity	1.30988141770642	bayes_pls_golite062009
receptor signaling protein activity	1.27291233344322	bayes_pls_golite062009
protein binding	1.22565748038754	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
transcription factor activity	1.18212353139877	bayes_pls_golite062009
DNA binding	1.17130513163489	bayes_pls_golite062009
RNA binding	0.892334734235538	bayes_pls_golite062009
MAP kinase activity	0.81943579965027	bayes_pls_golite062009
cyclin-dependent protein kinase activity	0.499492353295369	bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity	0.48345772948903	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
MAP kinase kinase kinase activity	0.37115026509016	bayes_pls_golite062009
MAP kinase kinase activity	0.35402045013148	bayes_pls_golite062009
molecular transducer activity	0.270054246024761	bayes_pls_golite062009
signal transducer activity	0.270054246024761	bayes_pls_golite062009
transmembrane receptor protein kinase activity	0.0556163711947139	bayes_pls_golite062009
transmembrane receptor activity	0.00652065412910241	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [271-544]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSAQERKTFA KNPTKNSKPA GQVIPSSPFT STLSRFPSLE GAVSEISLRD SQKHNSHPNS  60
   61 PFSSGDNSLI LDGVNGSQEP VPKITVKIAD LGNACWTRKH FTNDVQTRQY RSPEVILGCR 120
  121 WGASADCWSF ACIIFELLTG DYLFDPRNGN SYSKEDDHIA QIIELLVNYP KQMALSGKHS 180
  181 RDLFNRRGEL RNIHKLKFWP LKDVLEQKYH FSAELAQQIS DFLSPMLCFD PAKRTNAGYM 240
  241 SNSPWLREVA DPTFKIETTG ATGEDVPGWA TEIR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	15.09691
Match:	1pjkA
Description:	Protein kinase CK2, alpha subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphotransferase activity, alcohol group as acceptor	5.49988294224815	bayes_pls_golite062009
protein kinase activity	5.4586557943719	bayes_pls_golite062009
kinase activity	5.3287080791198	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.96052051118534	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
transferase activity	3.97138602499442	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
nucleic acid binding	1.46547714006072	bayes_pls_golite062009
protein tyrosine kinase activity	1.3898059094397	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.38496328649031	bayes_pls_golite062009
transcription regulator activity	1.30988141770642	bayes_pls_golite062009
receptor signaling protein activity	1.27291233344322	bayes_pls_golite062009
protein binding	1.22565748038754	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
transcription factor activity	1.18212353139877	bayes_pls_golite062009
DNA binding	1.17130513163489	bayes_pls_golite062009
RNA binding	0.892334734235538	bayes_pls_golite062009
MAP kinase activity	0.81943579965027	bayes_pls_golite062009
cyclin-dependent protein kinase activity	0.499492353295369	bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity	0.48345772948903	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
MAP kinase kinase kinase activity	0.37115026509016	bayes_pls_golite062009
MAP kinase kinase activity	0.35402045013148	bayes_pls_golite062009
molecular transducer activity	0.270054246024761	bayes_pls_golite062009
signal transducer activity	0.270054246024761	bayes_pls_golite062009
transmembrane receptor protein kinase activity	0.0556163711947139	bayes_pls_golite062009
transmembrane receptor activity	0.00652065412910241	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: