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Protein Overview: Cyp308a1-PA

General Information:
Name(s) found: Cyp308a1-PA / FBpp0074375 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene Cyp308a1 is referred to in FlyBase by the symbol Dmel\Cyp308a1 (CG6585, FBgn0030949). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:18603898..18605672. It has the cytological map location 17D1. Based on sequence similarity, it is predicted to have molecular function</span>: electron carrier activity. It is reported to be involved in the biological process</span>: insecticide metabolic process. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 490 amino acids

    Gene Ontology:
    Cellular Component: membrane [NAS]
    microsome [NAS]
    Biological Process: insecticide metabolic process [NAS]
    oxidation reduction [IEA]
    Molecular Function: electron carrier activity [IEA][ISS][NAS]
    monooxygenase activity [IEA]
    heme binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLPLVLFILL AATLLFWKWQ GNHWRRLGLE APFGWPLVGN MLDFALGRRS YGEIYQEIYT  60
   61 RNPGLKYVGF YRLFNEPAIL VRDQELLRQI LVGRNFADCA DNAVYVDHQR DVLASHNPFI 120
  121 ANGDRWRVLR ADLVPLFTPS RVRQTLPHVA RACQLLRDQV PLGRFEAKDL ATRYTLQVVA 180
  181 SAIFGLDAHC LGIHMRVAHE PSRWLEWLAP LFQPSVWSLL ETMSLLHTPR LGRLIGHRYV 240
  241 PLPLQHWFRE LVEARSGGDN LLQWLAESKR GLGKEELAGH ATTLLLEGYE TSAMLLAFAL 300
  301 YELALNEDAQ RRLHIELDEV AQRHAGNLID PVALGELRYS EAALLEALRL HPAMQALQKR 360
  361 CTKTFTLPDQ KSGASSELKV HLGTVLVLPV QAIHLDPALY PAPNQFRPER FLNQPPMGCR 420
  421 FLGFGAGPRM CPGMRLGLLQ TKAALTTLLQ DHCVQLADED QCRVEVSPLT FLTASRNGIW 480
  481 LSFKRRTRRY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..490] PSI-BLAST 92.69897 Crystal Structure of Human Microsomal P450 3A4

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • fatty acid (omega-1)-hydroxylase activity
    		•  6.3313834755701 bayes_pls_golite062009
  • monooxygenase activity
    		•  5.57229509004705 bayes_pls_golite062009
  • steroid hydroxylase activity
    		•  5.04794778387361 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  3.24344797738248 bayes_pls_golite062009
  • arachidonic acid monooxygenase activity
    		•  3.03830845324387 bayes_pls_golite062009
  • oxygen binding
    		•  2.77495508953933 bayes_pls_golite062009
  • retinoic acid 4-hydroxylase activity
    		•  2.60901411823382 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
    		•  2.56821164444595 bayes_pls_golite062009
  • demethylase activity
    		•  2.17116413461366 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.09151585300316 bayes_pls_golite062009
  • retinoid binding
    		•  1.91237853759594 bayes_pls_golite062009
  • isoprenoid binding
    		•  1.78853880472253 bayes_pls_golite062009
  • oxysterol 7-alpha-hydroxylase activity
    		•  1.71732865382274 bayes_pls_golite062009
  • sterol 14-demethylase activity
    		•  1.68985995159863 bayes_pls_golite062009
  • vitamin D3 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • vitamin D 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • retinoic acid binding
    		•  1.55035199545719 bayes_pls_golite062009
  • electron carrier activity
    		•  1.48516712188486 bayes_pls_golite062009
  • arachidonic acid 11,12-epoxygenase activity
    		•  1.48500938886158 bayes_pls_golite062009
  • testosterone 6-beta-hydroxylase activity
    		•  1.4661447981611 bayes_pls_golite062009
  • arachidonic acid epoxygenase activity
    		•  1.4220050618113 bayes_pls_golite062009
  • binding
    		•  1.2866152532988 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
    		•  1.20113920678403 bayes_pls_golite062009
  • vitamin D 24-hydroxylase activity
    		•  1.03699542179837 bayes_pls_golite062009
  • flavonoid 3'-monooxygenase activity
    		•  0.89030345144459 bayes_pls_golite062009
  • ecdysteroid 25-hydroxylase activity
    		•  0.89030345144459 bayes_pls_golite062009
  • catalytic activity
    		•  0.608111453189583 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
    		•  0.33710488712754 bayes_pls_golite062009
  • steroid 17-alpha-monooxygenase activity
    		•  0.252480305257929 bayes_pls_golite062009
  • 25-hydroxycholecalciferol-24-hydroxylase activity
    		•  0.167565425989292 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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