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Protein Overview: Frq2-PC, Frq2-PB...

General Information:
Name(s) found: FBpp0305513 [FlyBase]
Frq2-PC / FBpp0089318 [FlyBase]
Frq2-PB / FBpp0089317 [FlyBase]
Frq2-PA / FBpp0074320 [FlyBase]
Description(s) found:
Found 50 descriptions.
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  • type=protein; loc=X:join(18086533..18086596,18093157..18093181,18093807..18093855,18094688..18094777,18094863..18094941,18095176..18095264,18095325..18095492); ID=FBpp0305513; name=Frq2-PD; parent=FBgn0083228,FBtr0333321; dbxref=REFSEQ:NP_001259675,GB_protein:AGB95517,FlyBase:FBpp0305513,FlyBase_Annotation_IDs:CG5907-PD; MD5=dbaa3001121d19cb7410c576ce64d7f4; length=187; release=r5.56; species=Dmel; [FlyBase]
  • The gene Frequenin 2 is referred to in FlyBase by the symbol Dmel\Frq2 (CG5907, FBgn0083228). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:18080190..18096871. It has the cytological map location 17A1-17A2. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: calcium ion binding. There is experimental evidence that it is involved in the biological process</span>: synaptic transmission; neuromuscular junction development. 7 alleles are reported. The phenotypes of these alleles are annotated with: larval neuromuscular junction; type I bouton. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene Frequenin 2 is referred to in FlyBase by the symbol Dmel\Frq2 (CG5907, FBgn0083228). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:18080190..18096871. It has the cytological map location 17A1-17A2. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: calcium ion binding. There is experimental evidence that it is involved in the biological process</span>: synaptic transmission; neuromuscular junction development. 7 alleles are reported. The phenotypes of these alleles are annotated with: larval neuromuscular junction; type I bouton. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene Frequenin 2 is referred to in FlyBase by the symbol Dmel\Frq2 (CG5907, FBgn0083228). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:18080190..18096871. It has the cytological map location 17A1-17A2. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: calcium ion binding. There is experimental evidence that it is involved in the biological process</span>: synaptic transmission; neuromuscular junction development. 7 alleles are reported. The phenotypes of these alleles are annotated with: larval neuromuscular junction; type I bouton. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 187 amino acids

    Gene Ontology:
    Cellular Component: synaptic vesicle [NAS]
    Biological Process: neuromuscular junction development [IMP]
    regulation of neurotransmitter secretion [IGI]
    vesicle-mediated transport [NAS]
    synaptic transmission [IMP]
    neurotransmitter secretion [NAS]
    Molecular Function: calcium ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKKNSKLKQ DTIDRLTTDT YFTEKEIRQW HKGFLKDCPN GLLTEQGFIK IYKQFFPDGD  60
   61 PSKFASLVFR VFDENNDGAI EFEEFIRALS ITSRGNLDEK LHWAFRLYDV DNDGYITREE 120
  121 MYNIVDAIYQ MVGQQPQTED ENTPQKRVDK IFDQMDKNHD DRLTLEEFRE GSKADPRIVQ 180
  181 ALSLGGD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..187] PSI-BLAST 32.69897 Frequenin (neuronal calcium sensor 1)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  7.47426847861728 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  6.37104157544514 bayes_pls_golite062009
  • phosphatase activity
    		•  6.28157965296365 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  6.17799259119197 bayes_pls_golite062009
  • calcium-dependent protein serine/threonine phosphatase activity
    		•  5.58369939851095 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  5.11186887221409 bayes_pls_golite062009
  • calcium-dependent protein serine/threonine phosphatase regulator activity
    		•  4.70715233640875 bayes_pls_golite062009
  • calcium ion binding
    		•  3.79609619542776 bayes_pls_golite062009
  • binding
    		•  3.17556402087346 bayes_pls_golite062009
  • metal ion binding
    		•  2.62077305565026 bayes_pls_golite062009
  • cation binding
    		•  2.62077305565026 bayes_pls_golite062009
  • ion binding
    		•  2.61312132078717 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.57032504567157 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.55650624542181 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.37465721152046 bayes_pls_golite062009
  • clathrin binding
    		•  2.36616108128297 bayes_pls_golite062009
  • protein binding
    		•  2.21291432166051 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.99763594451773 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.9739523190593 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.6550001867465 bayes_pls_golite062009
  • DNA binding
    		•  1.55722307354604 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.53225451586959 bayes_pls_golite062009
  • structural constituent of muscle
    		•  1.30577051923353 bayes_pls_golite062009
  • calcium-dependent protein kinase inhibitor activity
    		•  1.29632226581856 bayes_pls_golite062009
  • actin filament binding
    		•  1.25849450788569 bayes_pls_golite062009
  • actin binding
    		•  1.1967948958876 bayes_pls_golite062009
  • transporter activity
    		•  1.15928534291452 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.11607939838219 bayes_pls_golite062009
  • signal transducer activity
    		•  1.11607939838219 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.945691505472547 bayes_pls_golite062009
  • phosphatase regulator activity
    		•  0.87149881541475 bayes_pls_golite062009
  • motor activity
    		•  0.85125321350375 bayes_pls_golite062009
  • guanylate cyclase regulator activity
    		•  0.84389905735679 bayes_pls_golite062009
  • cyclase regulator activity
    		•  0.84389905735679 bayes_pls_golite062009
  • protein phosphatase regulator activity
    		•  0.822713961141111 bayes_pls_golite062009
  • cation channel activity
    		•  0.802117767859521 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.787740261079819 bayes_pls_golite062009
  • kinase activity
    		•  0.782396352346639 bayes_pls_golite062009
  • calcium channel regulator activity
    		•  0.7164851905066 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.693724160233023 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.666488715029225 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.654002071540024 bayes_pls_golite062009
  • calcium sensitive guanylate cyclase activator activity
    		•  0.630360514213104 bayes_pls_golite062009
  • microfilament motor activity
    		•  0.515693296786409 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.386960491413065 bayes_pls_golite062009
  • channel activity
    		•  0.386960491413065 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.362205423422174 bayes_pls_golite062009
    		• 0.34446792626966 bayes_pls_golite062009
  • ion channel activity
    		•  0.343477643719352 bayes_pls_golite062009
  • channel regulator activity
    		•  0.32809521759917 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.308919475701377 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.304496519713588 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  0.278054748078249 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.246383459363256 bayes_pls_golite062009
  • potassium channel activity
    		•  0.200283164564768 bayes_pls_golite062009
  • gated channel activity
    		•  0.150185445887481 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  0.109511951498555 bayes_pls_golite062009
  • protein complex binding
    		•  0.0676093357928913 bayes_pls_golite062009
  • structural molecule activity
    		•  0.048100972187449 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle