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Protein Overview: B-H2-PA

General Information:
Name(s) found: B-H2-PA / FBpp0074203 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene BarH2 is referred to in FlyBase by the symbol Dmel\B-H2 (CG5488, FBgn0004854). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:17208614..17218195. It has the cytological map location 16A1. It is reported to have molecular function</span>: specific RNA polymerase II transcription factor activity; DNA binding; transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: sensory organ boundary specification; compound eye photoreceptor cell differentiation; leg disc proximal/distal pattern formation; eye-antennal disc morphogenesis; eye pigment granule organization; bristle morphogenesis. 8 alleles are reported. The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: adult segment; thoracic segment; metatarsus; organ system; peripheral nervous system; appendage segment; adult mesothoracic segment; nervous system; imaginal precursor; morphogenetic furrow; external compound sense organ. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 645 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA][NAS]
    Biological Process: sensory organ boundary specification [IMP]
    compound eye photoreceptor cell differentiation [IMP]
    bristle morphogenesis [IMP]
    eye-antennal disc morphogenesis [IMP]
    regulation of transcription, DNA-dependent [IEA][NAS]
    eye pigment granule organization [IMP]
    regulation of transcription [IEA]
    leg disc proximal/distal pattern formation [IMP]
    Molecular Function: DNA binding [NAS]
    transcription factor activity [IEA][NAS]
    specific RNA polymerase II transcription factor activity [NAS]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTMPPEMSA TTAAPVGSAP SATAHHPAAV GGGMPRPASP AVGSNTTTAT ATTATRSRFM  60
   61 ITDILAGAAA ASAAAAAAAA ALAAASSGGG RGSPTDSERE QSLVAQHHHH HQQQQQHHHH 120
  121 QQQQQQQQHQ QAALQQYIVQ QQQLLRFERE REREREREHY RERHSPPGNN PYAHHPMPPH 180
  181 LLAHFPPAHY AVLQQQQQQQ QQQQHPHPHH LQLERERLEA LHRHGHGLTG DPAQHLSHLS 240
  241 HLSHQQHHPH LHHPMHDERS RSPLMLQQLG GNGGNNNNNN NNSSSASNNN NNNNNSASAN 300
  301 SNIISGNSSS SNNNNGSGNG NMLLGGPGSS ISGDQASTID DSDSDDCGGK DDDGDDSMKN 360
  361 GSSANGDSSS HLSLSLSKKQ RKARTAFTDH QLQTLEKSFE RQKYLSVQDR MELANKLELS 420
  421 DCQVKTWYQN RRTKWKRQTA VGLELLAEAG NYAAFQRLYG GATPYLSAWP YAAAAAAQSP 480
  481 HGATPSAIDI YYRQAAAAAA MQKPSLPASY RMYQSSIPPG MSLPGMPAPP PPGAAPMLSG 540
  541 YYAAAAAAAA SAGAQQQQQQ PPAASRSPAT SQSANSEADC ERTSSSSRQR LITPSPPLNP 600
  601 GSPPHRERIN EEEDRERDEE RDIERERERE RERDEDDEEE LALEV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..129] FFAS03 1.15 The structure of a modular endo-beta-1,4-mannanase from Cellulomonas fimi explains the product specificity of glycoside hydrolase family 26 mannanases.
    2 View Details [130..345] PSI-BLAST 3.39794 Sec24
    3 View Details [346..448] PSI-BLAST 12.522879 Homeobox protein hox-b1
    4 View Details [449..645] FFAS03 0.979 Crystal Structure of Rat Synapsin I C Domain Complexed to Ca.ATP

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.59063189683655 bayes_pls_golite062009
  • protein binding
    		•  1.40069187357924 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  1.12064341222676 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  1.12064341222676 bayes_pls_golite062009
  • gated channel activity
    		•  1.07009061846204 bayes_pls_golite062009
  • cation channel activity
    		•  1.06128106743399 bayes_pls_golite062009
  • ion channel activity
    		•  1.05202649422365 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  1.0312639599585 bayes_pls_golite062009
  • channel activity
    		•  1.02722503832082 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  1.02722503832082 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.558441391308061 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.474611134490695 bayes_pls_golite062009
  • actin binding
    		•  0.471997325585296 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  0.410123587360906 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.35572857442145 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.347698520417586 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.302562057767319 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  0.23135104785491 bayes_pls_golite062009
  • potassium channel activity
    		•  0.111061655187583 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  0.0516610623213176 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.26183812259792 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.14886080629275 bayes_pls_golite062009
  • chromatin binding
    		•  1.04132983826241 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009
    4
    Term Confidence Notes
  • binding
    		•  1.94828015862607 bayes_pls_golite062009
  • catalytic activity
    		•  1.01989895762614 bayes_pls_golite062009
  • ligase activity
    		•  0.64896140325006 bayes_pls_golite062009
  • protein binding
    		•  0.458461360580002 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.406646146913593 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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