Protein Overview: shi-PK, shi-PF, ...

General Information:
Name(s) found:	shi-PK / FBpp0290810 [FlyBase] shi-PJ / FBpp0290809 [FlyBase] shi-PF / FBpp0089280 [FlyBase] shi-PG / FBpp0089277 [FlyBase]
Description(s) found: Found 52 descriptions. SHOW ALL	The gene shibire is referred to in FlyBase by the symbol Dmel\shi (CG18102, FBgn0003392). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:15786149..15800285. It has the cytological map location 13F18. There is experimental evidence that it has the molecular function</span>: actin binding; microtubule binding. There is experimental evidence for 29 unique biological process</span> terms, many of which group under: anatomical structure development; reproductive process in a multicellular organism; regulation of biological process; learning or memory; mating; memory; system process; transport; cellular component movement; learning. 70 alleles are reported. The phenotypes of these alleles are annotated with 64 unique terms, many of which group under: external compound sense organ; peripheral nervous system; adult segment; nervous system; organ system; adult mesothoracic segment; female germline cyst; antennal segment; late extended germ band embryo; adult brain. It has 12 annotated transcripts and 12 annotated polypeptides. [FlyBase] The gene shibire is referred to in FlyBase by the symbol Dmel\shi (CG18102, FBgn0003392). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:15786149..15800285. It has the cytological map location 13F18. There is experimental evidence that it has the molecular function</span>: actin binding; microtubule binding. There is experimental evidence for 29 unique biological process</span> terms, many of which group under: anatomical structure development; reproductive process in a multicellular organism; regulation of biological process; learning or memory; mating; memory; system process; transport; cellular component movement; learning. 70 alleles are reported. The phenotypes of these alleles are annotated with 64 unique terms, many of which group under: external compound sense organ; peripheral nervous system; adult segment; nervous system; organ system; adult mesothoracic segment; female germline cyst; antennal segment; late extended germ band embryo; adult brain. It has 12 annotated transcripts and 12 annotated polypeptides. [FlyBase] The gene shibire is referred to in FlyBase by the symbol Dmel\shi (CG18102, FBgn0003392). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:15786149..15800285. It has the cytological map location 13F18. There is experimental evidence that it has the molecular function</span>: actin binding; microtubule binding. There is experimental evidence for 29 unique biological process</span> terms, many of which group under: anatomical structure development; reproductive process in a multicellular organism; regulation of biological process; learning or memory; mating; memory; system process; transport; cellular component movement; learning. 70 alleles are reported. The phenotypes of these alleles are annotated with 64 unique terms, many of which group under: external compound sense organ; peripheral nervous system; adult segment; nervous system; organ system; adult mesothoracic segment; female germline cyst; antennal segment; late extended germ band embryo; adult brain. It has 12 annotated transcripts and 12 annotated polypeptides. [FlyBase] The gene shibire is referred to in FlyBase by the symbol Dmel\shi (CG18102, FBgn0003392). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:15786149..15800285. It has the cytological map location 13F18. There is experimental evidence that it has the molecular function</span>: actin binding; microtubule binding. There is experimental evidence for 29 unique biological process</span> terms, many of which group under: anatomical structure development; reproductive process in a multicellular organism; regulation of biological process; learning or memory; mating; memory; system process; transport; cellular component movement; learning. 70 alleles are reported. The phenotypes of these alleles are annotated with 64 unique terms, many of which group under: external compound sense organ; peripheral nervous system; adult segment; nervous system; organ system; adult mesothoracic segment; female germline cyst; antennal segment; late extended germ band embryo; adult brain. It has 12 annotated transcripts and 12 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	877 amino acids
Gene Ontology:
Cellular Component:	sperm individualization complex [IDA] synapse [IMP] microtubule associated complex [ISS] plasma membrane [IDA]
Biological Process:	sperm individualization [IGI][IMP] male courtship behavior [IMP] pole cell formation [TAS] cytokinesis [IMP][TAS] border follicle cell migration [IMP] memory [IMP][TAS] microtubule-based process [NAS] learning or memory [IDA] salivary gland morphogenesis [IMP] epithelial cell migration, open tracheal system [IMP] response to heat [IMP] male courtship behavior, veined wing extension [IMP] vesicle-mediated transport [TAS] synaptic vesicle endocytosis [IMP][TAS] olfactory learning [IDA] male courtship behavior, veined wing generated song production [IMP] endocytosis [IMP][NAS][TAS] cellularization [IMP][TAS] receptor-mediated endocytosis [NAS] conditioned taste aversion [IMP] open tracheal system development [IMP] larval feeding behavior [IMP] short-term memory [IMP] regulation of actin cytoskeleton organization [IGI] proboscis extension reflex [IMP] synaptic vesicle membrane organization [IMP] synaptic vesicle budding from presynaptic membrane [IMP][TAS] regulation of synapse structure and activity [IMP] extracellular matrix organization [IMP] morphogenesis of a polarized epithelium [IMP] adherens junction maintenance [IMP] regulation of actin filament-based process [IGI] regulation of short-term neuronal synaptic plasticity [IMP]
Molecular Function:	GTP binding [IEA] microtubule motor activity [NAS] actin binding [IDA] GTPase activity [ISS][NAS] microtubule binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSLITIVNK LQDAFTSLGV HMQLDLPQIA VVGGQSAGKS SVLENFVGKD FLPRGSGIVT  60
   61 RRPLILQLIN GVTEYGEFLH IKGKKFSSFD EIRKEIEDET DRVTGSNKGI SNIPINLRVY 120
  121 SPHVLNLTLI DLPGLTKVAI GDQPVDIEQQ IKQMIFQFIR KETCLILAVT PANTDLANSD 180
  181 ALKLAKEVDP QGVRTIGVIT KLDLMDEGTD ARDILENKLL PLRRGYIGVV NRSQKDIEGR 240
  241 KDIHQALAAE RKFFLSHPSY RHMADRLGTP YLQRVLNQQL TNHIRDTLPG LRDKLQKQML 300
  301 TLEKEVEEFK HFQPGDASIK TKAMLQMIQQ LQSDFERTIE GSGSALVNTN ELSGGAKINR 360
  361 IFHERLRFEI VKMACDEKEL RREISFAIRN IHGIRVGLFT PDMAFEAIVK RQIALLKEPV 420
  421 IKCVDLVVQE LSVVVRMCTA KMSRYPRLRE ETERIITTHV RQREHSCKEQ ILLLIDFELA 480
  481 YMNTNHEDFI GFANAQNKSE NANKTGTRQL GNQVIRKGHM VIQNLGIMKG GSRPYWFVLT 540
  541 SESISWYKDE DEKEKKFMLP LDGLKLRDIE QGFMSMSRRV TFALFSPDGR NVYKDYKQLE 600
  601 LSCETVEDVE SWKASFLRAG VYPEKQETQE NGDESASEES SSDPQLERQV ETIRNLVDSY 660
  661 MKIVTKTTRD MVPKAIMMLI INNAKDFING ELLAHLYASG DQAQMMEESA ESATRREEML 720
  721 RMYRACKDAL QIIGDVSMAT VSSPLPPPVK NDWLPSGLDN PRLSPPSPGG VRGKPGPPAQ 780
  781 SSLGGRNPPL PPSTGRPAPA IPNRPGGGAP PLPGGRPGGS LPPPMLPSRV SGAVGGAIVQ 840
  841 QSGANRYVPE SMRGQVNQAV GQAAINELSN AFSSRFK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..313]	PSI-BLAST	131.0	Structure of the nucleotide-free myosin II motor domain from Dictyostelium discoideum fused to the GTPase domain of dynamin 1 from Rattus norvegicus
2	View Details	[314..508]	MSA	1.231963	View MSA. No confident structure predictions are available.
3	View Details	[509..633]	PSI-BLAST	17.221849	Dynamin
4	View Details	[634..720]	Pfam	17.568636	No description for PF02212.9 was found. Confident ab initio structure predictions are available.
5	View Details	[721..877]	PSI-BLAST	31.69897	No description for 1y0fB was found.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
microtubule motor activity	6.13591371239337	bayes_pls_golite062009
motor activity	4.04927796049806	bayes_pls_golite062009
transporter activity	3.10463051760206	bayes_pls_golite062009
transmembrane transporter activity	2.95886887664984	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.95079405147356	bayes_pls_golite062009
pyrophosphatase activity	2.87427509025394	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.85499564954033	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.85178667290149	bayes_pls_golite062009
tubulin binding	2.67743463093593	bayes_pls_golite062009
plus-end-directed microtubule motor activity	2.65631438185675	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
primary active transmembrane transporter activity	2.61775212528604	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	2.61467977505707	bayes_pls_golite062009
microtubule binding	2.59155206524122	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	2.57552435627908	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	2.57107347424517	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	2.57054427875021	bayes_pls_golite062009
microfilament motor activity	2.51786963027655	bayes_pls_golite062009
active transmembrane transporter activity	2.50494515048649	bayes_pls_golite062009
ATPase activity, coupled	2.43862163407966	bayes_pls_golite062009
cytoskeletal protein binding	2.4101693596493	bayes_pls_golite062009
ATPase activity	2.39535714892224	bayes_pls_golite062009
actin binding	2.2973522188675	bayes_pls_golite062009
nucleic acid binding	2.21184938313192	bayes_pls_golite062009
DNA binding	2.12258000781149	bayes_pls_golite062009
transcription regulator activity	2.09345198747025	bayes_pls_golite062009
substrate-specific transporter activity	1.91091452720653	bayes_pls_golite062009
hydrolase activity	1.57549510726226	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.56325751172863	bayes_pls_golite062009
actin filament binding	1.28204719195916	bayes_pls_golite062009
protein binding	1.22129154759482	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
ion transmembrane transporter activity	0.977237423302079	bayes_pls_golite062009
purine nucleotide binding	0.929901285538132	bayes_pls_golite062009
nucleotide binding	0.922442819194247	bayes_pls_golite062009
actin-dependent ATPase activity	0.92105578610354	bayes_pls_golite062009
purine ribonucleotide binding	0.920987930180051	bayes_pls_golite062009
ribonucleotide binding	0.920926158369519	bayes_pls_golite062009
transcription factor activity	0.887108427603557	bayes_pls_golite062009
GTPase activity	0.83849854735032	bayes_pls_golite062009
molecular transducer activity	0.683309012097319	bayes_pls_golite062009
signal transducer activity	0.683309012097319	bayes_pls_golite062009
glutamate receptor binding	0.67946233728984	bayes_pls_golite062009
cation transmembrane transporter activity	0.557919489256916	bayes_pls_golite062009
ATP binding	0.41092997612902	bayes_pls_golite062009
adenyl ribonucleotide binding	0.385813421701492	bayes_pls_golite062009
adenyl nucleotide binding	0.377870145186619	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	0.213018989352421	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	0.123304946374679	bayes_pls_golite062009
structural constituent of ribosome	0.089234257580272	bayes_pls_golite062009
helicase activity	0.0775311459068899	bayes_pls_golite062009
minus-end-directed microtubule motor activity	0.068779631341469	bayes_pls_golite062009
structural constituent of cytoskeleton	0.0111338193708552	bayes_pls_golite062009

No functions predicted.

Term	Confidence	Notes
actin binding	3.72754591832642	bayes_pls_golite062009
cytoskeletal protein binding	3.48744511411671	bayes_pls_golite062009
binding	3.29080729281876	bayes_pls_golite062009
protein binding	3.17213698546013	bayes_pls_golite062009
transcription regulator activity	2.10584700564436	bayes_pls_golite062009
actin filament binding	2.03444575838575	bayes_pls_golite062009
DNA binding	1.77960272183811	bayes_pls_golite062009
glutamate receptor binding	1.76346239890943	bayes_pls_golite062009
molecular transducer activity	1.55319485371003	bayes_pls_golite062009
signal transducer activity	1.55319485371003	bayes_pls_golite062009
nucleic acid binding	1.55295906221034	bayes_pls_golite062009
clathrin binding	1.29927347270153	bayes_pls_golite062009
transporter activity	1.28986800087234	bayes_pls_golite062009
phospholipid binding	1.09683218092034	bayes_pls_golite062009
receptor binding	1.00859318603128	bayes_pls_golite062009
protein domain specific binding	0.90578029954417	bayes_pls_golite062009
substrate-specific transporter activity	0.79883446648737	bayes_pls_golite062009
phosphoinositide binding	0.71817045430443	bayes_pls_golite062009
profilin binding	0.66906205737225	bayes_pls_golite062009
structural constituent of cytoskeleton	0.35466574267734	bayes_pls_golite062009
receptor activity	0.353510125274044	bayes_pls_golite062009
phosphoinositide 3-kinase binding	0.35270637154617	bayes_pls_golite062009
beta-amyloid binding	0.34714857141225	bayes_pls_golite062009
transmembrane receptor activity	0.207829786337892	bayes_pls_golite062009
structural molecule activity	0.160152014803717	bayes_pls_golite062009
protein complex binding	0.15504114076075	bayes_pls_golite062009
alpha-catenin binding	0.102004310679969	bayes_pls_golite062009
receptor signaling protein activity	0.10105990547756	bayes_pls_golite062009
pyrophosphatase activity	0.0611639610381174	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0524559849408587	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.0498422520006935	bayes_pls_golite062009

No functions predicted.

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Protein Overview: shi-PK, shi-PF, ...

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: