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View Structure Prediction Details

Protein: shi-PK, shi-PF, ...
Organism: Drosophila melanogaster
Length: 877 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for shi-PK, shi-PF, ....

Description E-value Query
Range		 Subject
Range
gi|123230375, gi... - gi|123230375|emb|CAM15853.1| dynamin 1 [Mus musculus], gi|116063570|ref|NP_034195.2| dynamin [Mus mu...
 863.0 [0..1] [858..6]

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Predicted Domain #1
Region A:
Residues: [1-313] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSLITIVNK LQDAFTSLGV HMQLDLPQIA VVGGQSAGKS SVLENFVGKD FLPRGSGIVT  60
   61 RRPLILQLIN GVTEYGEFLH IKGKKFSSFD EIRKEIEDET DRVTGSNKGI SNIPINLRVY 120
  121 SPHVLNLTLI DLPGLTKVAI GDQPVDIEQQ IKQMIFQFIR KETCLILAVT PANTDLANSD 180
  181 ALKLAKEVDP QGVRTIGVIT KLDLMDEGTD ARDILENKLL PLRRGYIGVV NRSQKDIEGR 240
  241 KDIHQALAAE RKFFLSHPSY RHMADRLGTP YLQRVLNQQL TNHIRDTLPG LRDKLQKQML 300
  301 TLEKEVEEFK HFQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 131.0
Match: 2akaB
Description: Structure of the nucleotide-free myosin II motor domain from Dictyostelium discoideum fused to the GTPase domain of dynamin 1 from Rattus norvegicus
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
microtubule motor activity 6.13591371239337 bayes_pls_golite062009
motor activity 4.04927796049806 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
tubulin binding 2.67743463093593 bayes_pls_golite062009
plus-end-directed microtubule motor activity 2.65631438185675 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
primary active transmembrane transporter activity 2.61775212528604 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.61467977505707 bayes_pls_golite062009
microtubule binding 2.59155206524122 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.57552435627908 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.57107347424517 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.57054427875021 bayes_pls_golite062009
microfilament motor activity 2.51786963027655 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
ATPase activity, coupled 2.43862163407966 bayes_pls_golite062009
cytoskeletal protein binding 2.4101693596493 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
actin binding 2.2973522188675 bayes_pls_golite062009
nucleic acid binding 2.21184938313192 bayes_pls_golite062009
DNA binding 2.12258000781149 bayes_pls_golite062009
transcription regulator activity 2.09345198747025 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
hydrolase activity 1.57549510726226 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.56325751172863 bayes_pls_golite062009
actin filament binding 1.28204719195916 bayes_pls_golite062009
protein binding 1.22129154759482 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
ion transmembrane transporter activity 0.977237423302079 bayes_pls_golite062009
purine nucleotide binding 0.929901285538132 bayes_pls_golite062009
nucleotide binding 0.922442819194247 bayes_pls_golite062009
actin-dependent ATPase activity 0.92105578610354 bayes_pls_golite062009
purine ribonucleotide binding 0.920987930180051 bayes_pls_golite062009
ribonucleotide binding 0.920926158369519 bayes_pls_golite062009
transcription factor activity 0.887108427603557 bayes_pls_golite062009
GTPase activity 0.83849854735032 bayes_pls_golite062009
molecular transducer activity 0.683309012097319 bayes_pls_golite062009
signal transducer activity 0.683309012097319 bayes_pls_golite062009
glutamate receptor binding 0.67946233728984 bayes_pls_golite062009
cation transmembrane transporter activity 0.557919489256916 bayes_pls_golite062009
ATP binding 0.41092997612902 bayes_pls_golite062009
adenyl ribonucleotide binding 0.385813421701492 bayes_pls_golite062009
adenyl nucleotide binding 0.377870145186619 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 0.213018989352421 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.123304946374679 bayes_pls_golite062009
structural constituent of ribosome 0.089234257580272 bayes_pls_golite062009
helicase activity 0.0775311459068899 bayes_pls_golite062009
minus-end-directed microtubule motor activity 0.068779631341469 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0111338193708552 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [314-508] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGDASIKTKA MLQMIQQLQS DFERTIEGSG SALVNTNELS GGAKINRIFH ERLRFEIVKM  60
   61 ACDEKELRRE ISFAIRNIHG IRVGLFTPDM AFEAIVKRQI ALLKEPVIKC VDLVVQELSV 120
  121 VVRMCTAKMS RYPRLREETE RIITTHVRQR EHSCKEQILL LIDFELAYMN TNHEDFIGFA 180
  181 NAQNKSENAN KTGTR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [509-633] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLGNQVIRKG HMVIQNLGIM KGGSRPYWFV LTSESISWYK DEDEKEKKFM LPLDGLKLRD  60
   61 IEQGFMSMSR RVTFALFSPD GRNVYKDYKQ LELSCETVED VESWKASFLR AGVYPEKQET 120
  121 QENGD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.221849
Match: 2dynA
Description: Dynamin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 3.72754591832642 bayes_pls_golite062009
cytoskeletal protein binding 3.48744511411671 bayes_pls_golite062009
binding 3.29080729281876 bayes_pls_golite062009
protein binding 3.17213698546013 bayes_pls_golite062009
transcription regulator activity 2.10584700564436 bayes_pls_golite062009
actin filament binding 2.03444575838575 bayes_pls_golite062009
DNA binding 1.77960272183811 bayes_pls_golite062009
glutamate receptor binding 1.76346239890943 bayes_pls_golite062009
molecular transducer activity 1.55319485371003 bayes_pls_golite062009
signal transducer activity 1.55319485371003 bayes_pls_golite062009
nucleic acid binding 1.55295906221034 bayes_pls_golite062009
clathrin binding 1.29927347270153 bayes_pls_golite062009
transporter activity 1.28986800087234 bayes_pls_golite062009
phospholipid binding 1.09683218092034 bayes_pls_golite062009
receptor binding 1.00859318603128 bayes_pls_golite062009
protein domain specific binding 0.90578029954417 bayes_pls_golite062009
substrate-specific transporter activity 0.79883446648737 bayes_pls_golite062009
phosphoinositide binding 0.71817045430443 bayes_pls_golite062009
profilin binding 0.66906205737225 bayes_pls_golite062009
structural constituent of cytoskeleton 0.35466574267734 bayes_pls_golite062009
receptor activity 0.353510125274044 bayes_pls_golite062009
phosphoinositide 3-kinase binding 0.35270637154617 bayes_pls_golite062009
beta-amyloid binding 0.34714857141225 bayes_pls_golite062009
transmembrane receptor activity 0.207829786337892 bayes_pls_golite062009
structural molecule activity 0.160152014803717 bayes_pls_golite062009
protein complex binding 0.15504114076075 bayes_pls_golite062009
alpha-catenin binding 0.102004310679969 bayes_pls_golite062009
receptor signaling protein activity 0.10105990547756 bayes_pls_golite062009
pyrophosphatase activity 0.0611639610381174 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0524559849408587 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0498422520006935 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [634-720] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESASEESSSD PQLERQVETI RNLVDSYMKI VTKTTRDMVP KAIMMLIINN AKDFINGELL  60
   61 AHLYASGDQA QMMEESAESA TRREEML

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 17.568636
Match: PF02212.9
Description: No description for PF02212.9 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.988 N/A N/A a.7.1 Spectrin repeat

Predicted Domain #5
Region A:
Residues: [721-877] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RMYRACKDAL QIIGDVSMAT VSSPLPPPVK NDWLPSGLDN PRLSPPSPGG VRGKPGPPAQ  60
   61 SSLGGRNPPL PPSTGRPAPA IPNRPGGGAP PLPGGRPGGS LPPPMLPSRV SGAVGGAIVQ 120
  121 QSGANRYVPE SMRGQVNQAV GQAAINELSN AFSSRFK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 31.69897
Match: 1y0fB
Description: No description for 1y0fB was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle