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Protein Overview: l(1)G0007-PB

General Information:
Name(s) found: l(1)G0007-PB / FBpp0073718 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene lethal (1) G0007 is referred to in FlyBase by the symbol Dmel\l(1)G0007 (CG32604, FBgn0026713). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:14095405..14118761. It has the cytological map location 12E3-12E5. Based on sequence similarity, it is predicted to have molecular function</span>: ATP-dependent helicase activity; ATP-dependent RNA helicase activity. There is experimental evidence that it is involved in the biological process</span>: inter-male aggressive behavior; regulation of alternative nuclear mRNA splicing, via spliceosome. 52 alleles are reported. The phenotypes of these alleles are annotated with: macrochaeta; intersegmental nerve. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 534 amino acids

    Gene Ontology:
    Cellular Component: spliceosomal complex [ISS]
    Biological Process: regulation of alternative nuclear mRNA splicing, via spliceosome [IMP]
    inter-male aggressive behavior [IMP]
    nuclear mRNA splicing, via spliceosome [ISS]
    Molecular Function: nucleic acid binding [IEA]
    ATP binding [IEA]
    ATP-dependent helicase activity [ISS]
    ATP-dependent RNA helicase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSSKFATFF GNVPTFTIPG RTFPVDVMFS KNTCEDYVES AVKQALQVHL TPNEGDMLIF  60
   61 MPGQEDIEVT CEVLEERLAE IDNAPALSIL PIYSQLPSDL QAKIFQKSSD GLRKCVVATN 120
  121 IAETSLTVDG IIYVIDSGYC KLKVYNPRIG MDALQIYPIS QANANQRSGR AGRTGPGQAY 180
  181 RLYTQRQYKD ELLALTVPEI QRTNLANTVL LLKSLGVVDL LQFHFMDPPP QDNILNSLYQ 240
  241 LWILGALDHT GALTTLGRQM AEFPLDPPQC QMLIVACRMG CSAEVLIIVS MLSVPSIFYR 300
  301 PKGREDEADG VREKFQRPES DHLTYLNVYQ QWRQNNYSST WCNEHFIHIK AMRKVREVRQ 360
  361 QLKDIMTQQN LSVISCGIDW DIVRKCICSA YFYQAARLKG IGEYVNLRTG MPCHLHPTSA 420
  421 LYGLGTTPDY VVYHELIMTA KEYMQCATAV DGYWLAELGP MFFSVKESGR SGREKKKQAA 480
  481 EHLKEMEEQM LKAQHEMEER KQQAAEREEQ LATKQEIATP GNATPRRTPA RIGL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..371] PSI-BLAST 13.522879 Structure of the RecQ Catalytic Core
    2 View Details [372..534] Pfam 20.619789 No description for PF07717.7 was found. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
    		• 4.704140727858 bayes_pls_golite062009
  • RNA binding
    		•  2.29590582680214 bayes_pls_golite062009
  • binding
    		•  2.05253348982328 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.57653963868443 bayes_pls_golite062009
  • RNA helicase activity
    		•  1.42791449104435 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.41477043612798 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  1.39335733374328 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  1.36724390116598 bayes_pls_golite062009
  • DNA binding
    		•  1.11699929651302 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.989226939888218 bayes_pls_golite062009
  • hydrolase activity
    		•  0.770112659770838 bayes_pls_golite062009
  • mRNA binding
    		•  0.76699944561918 bayes_pls_golite062009
  • helicase activity
    		•  0.6191010101321 bayes_pls_golite062009
  • structural molecule activity
    		•  0.596382945962261 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.461763181659193 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.458831409927227 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.455976987338331 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.422944846459286 bayes_pls_golite062009
  • snRNA binding
    		•  0.418985924846052 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.29664013896754 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.29664013896754 bayes_pls_golite062009
  • nucleotide binding
    		•  0.114848452385726 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.10713474095071 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0916519414118148 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0915913646217636 bayes_pls_golite062009
  • transcription factor activity
    		•  0.0434163635422169 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle