Protein Overview: Hsp60-PB, Hsp60-PA

General Information:
Name(s) found:	Hsp60-PB / FBpp0073291 [FlyBase] Hsp60-PA / FBpp0073290 [FlyBase]
Description(s) found: Found 36 descriptions. SHOW ALL	The gene Heat shock protein 60 is referred to in FlyBase by the symbol Dmel\Hsp60 (CG12101, FBgn0015245). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:11002506..11006341. It has the cytological map location 10A4. Based on sequence similarity, it is predicted to have molecular function</span>: unfolded protein binding. Based on sequence similarity, it is predicted to be involved in the biological process</span>: response to heat; 'de novo' protein folding; protein targeting to mitochondrion; protein folding. 55 alleles are reported. The phenotypes of these alleles are annotated with: blastoderm embryo; tergite. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase] The gene Heat shock protein 60 is referred to in FlyBase by the symbol Dmel\Hsp60 (CG12101, FBgn0015245). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:11002506..11006341. It has the cytological map location 10A4. Based on sequence similarity, it is predicted to have molecular function</span>: unfolded protein binding. Based on sequence similarity, it is predicted to be involved in the biological process</span>: response to heat; 'de novo' protein folding; protein targeting to mitochondrion; protein folding. 55 alleles are reported. The phenotypes of these alleles are annotated with: blastoderm embryo; tergite. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	573 amino acids
Gene Ontology:
Cellular Component:	lipid particle [IDA] mitochondrial matrix [ISS][NAS] mitochondrion [IDA]
Biological Process:	protein targeting to mitochondrion [ISS] [NOT]response to heat [IEP][ISS][NAS] protein folding [ISS][NAS] protein refolding [NAS] 'de novo' protein folding [ISS] response to stress [NAS]
Molecular Function:	ATP binding [IEA] unfolded protein binding [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFRLPVSLAR SSISRQLAMR GYAKDVRFGP EVRAMMLQGV DVLADAVAVT MGPKGRNVII  60
   61 EQSWGSPKIT KDGVTVAKSI ELKDKFQNIG AKLVQDVANN TNEEAGDGTT TATVLARAIA 120
  121 KEGFEKISKG ANPVEIRRGV MLAVETVKDN LKTMSRPVST PEEIAQVATI SANGDQAIGN 180
  181 LISEAMKKVG RDGVITVKDG KTLTDELEVI EGMKFDRGYI SPYFINSSKG AKVEFQDALL 240
  241 LLSEKKISSV QSIIPALELA NAQRKPLVII AEDIDGEALS TLVVNRLKIG LQVAAVKAPG 300
  301 FGDNRKSTLT DMAIASGGIV FGDDADLVKL EDVKVSDLGQ VGEVVITKDD TLLLKGKGKK 360
  361 DDVLRRANQI KDQIEDTTSE YEKEKLQERL ARLASGVALL RVGGSSEVEV NEKKDRVHDA 420
  421 LNATRAAVEE GIVPGGGTAL LRCIEKLEGV ETTNEDQKLG VEIVRRALRM PCMTIAKNAG 480
  481 VDGAMVVAKV ENQAGDYGYD ALKGEYGNLI EKGIIDPTKV VRTAITDASG VASLLTTAEA 540
  541 VVTEIPKEDG APAMPGMGGM GGMGGMGGMG GMM

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
unfolded protein binding	9.9038451294995	bayes_pls_golite062009
binding	3.11215702001989	bayes_pls_golite062009
protein binding	3.08620110128651	bayes_pls_golite062009
misfolded protein binding	2.60932901317399	bayes_pls_golite062009
lipopolysaccharide binding	2.08823822762317	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	1.90846357786961	bayes_pls_golite062009
nucleoside-triphosphatase activity	1.88769858570433	bayes_pls_golite062009
ATPase activity	1.85640607183492	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.85422470116133	bayes_pls_golite062009
pyrophosphatase activity	1.81343301131567	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.79412354283105	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.79183933227438	bayes_pls_golite062009
nucleic acid binding	1.67284737458957	bayes_pls_golite062009
DNA binding	1.53776996197958	bayes_pls_golite062009
transporter activity	1.27879339110564	bayes_pls_golite062009
transmembrane transporter activity	1.08697283907212	bayes_pls_golite062009
chaperone binding	0.91200031047441	bayes_pls_golite062009
substrate-specific transporter activity	0.828920415160435	bayes_pls_golite062009
structure-specific DNA binding	0.650832159017275	bayes_pls_golite062009
hydrolase activity	0.577900060851977	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.573106450426516	bayes_pls_golite062009
insulin binding	0.54263404774246	bayes_pls_golite062009
ATPase activity, coupled	0.527748436977659	bayes_pls_golite062009
single-stranded DNA binding	0.44104272460881	bayes_pls_golite062009
cell surface binding	0.326492680678891	bayes_pls_golite062009
peptide hormone binding	0.280457039468896	bayes_pls_golite062009
ion transmembrane transporter activity	0.280310103153739	bayes_pls_golite062009
active transmembrane transporter activity	0.275534581026027	bayes_pls_golite062009
primary active transmembrane transporter activity	0.252704226951294	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.243984617084631	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.205808843369749	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.202279803135899	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.20198255686005	bayes_pls_golite062009
catalytic activity	0.107125378994589	bayes_pls_golite062009
cation transmembrane transporter activity	0.0778814959589007	bayes_pls_golite062009

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.59

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..573]	PSI-BLAST	163.0	GroEL, E domain; GroEL, A domain; GroEL, I domain

Protein Overview: Hsp60-PB, Hsp60-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: