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View Structure Prediction Details

Protein: Hsp60-PB, Hsp60-PA
Organism: Drosophila melanogaster
Length: 573 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Hsp60-PB, Hsp60-PA.

Description E-value Query
Range
Subject
Range
CH60_METFK - 60 kDa chaperonin OS=Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875) GN=groL PE=3 SV...
598.0 [0..21] [564..1]

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Predicted Domain #1
Region A:
Residues: [1-573]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFRLPVSLAR SSISRQLAMR GYAKDVRFGP EVRAMMLQGV DVLADAVAVT MGPKGRNVII  60
   61 EQSWGSPKIT KDGVTVAKSI ELKDKFQNIG AKLVQDVANN TNEEAGDGTT TATVLARAIA 120
  121 KEGFEKISKG ANPVEIRRGV MLAVETVKDN LKTMSRPVST PEEIAQVATI SANGDQAIGN 180
  181 LISEAMKKVG RDGVITVKDG KTLTDELEVI EGMKFDRGYI SPYFINSSKG AKVEFQDALL 240
  241 LLSEKKISSV QSIIPALELA NAQRKPLVII AEDIDGEALS TLVVNRLKIG LQVAAVKAPG 300
  301 FGDNRKSTLT DMAIASGGIV FGDDADLVKL EDVKVSDLGQ VGEVVITKDD TLLLKGKGKK 360
  361 DDVLRRANQI KDQIEDTTSE YEKEKLQERL ARLASGVALL RVGGSSEVEV NEKKDRVHDA 420
  421 LNATRAAVEE GIVPGGGTAL LRCIEKLEGV ETTNEDQKLG VEIVRRALRM PCMTIAKNAG 480
  481 VDGAMVVAKV ENQAGDYGYD ALKGEYGNLI EKGIIDPTKV VRTAITDASG VASLLTTAEA 540
  541 VVTEIPKEDG APAMPGMGGM GGMGGMGGMG GMM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 163.0
Match: 1iokA
Description: GroEL, E domain; GroEL, A domain; GroEL, I domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
unfolded protein binding 9.9038451294995 bayes_pls_golite062009
binding 3.11215702001989 bayes_pls_golite062009
protein binding 3.08620110128651 bayes_pls_golite062009
misfolded protein binding 2.60932901317399 bayes_pls_golite062009
lipopolysaccharide binding 2.08823822762317 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 1.90846357786961 bayes_pls_golite062009
nucleoside-triphosphatase activity 1.88769858570433 bayes_pls_golite062009
ATPase activity 1.85640607183492 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 1.85422470116133 bayes_pls_golite062009
pyrophosphatase activity 1.81343301131567 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 1.79412354283105 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.79183933227438 bayes_pls_golite062009
nucleic acid binding 1.67284737458957 bayes_pls_golite062009
DNA binding 1.53776996197958 bayes_pls_golite062009
transporter activity 1.27879339110564 bayes_pls_golite062009
transmembrane transporter activity 1.08697283907212 bayes_pls_golite062009
chaperone binding 0.91200031047441 bayes_pls_golite062009
substrate-specific transporter activity 0.828920415160435 bayes_pls_golite062009
structure-specific DNA binding 0.650832159017275 bayes_pls_golite062009
hydrolase activity 0.577900060851977 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.573106450426516 bayes_pls_golite062009
insulin binding 0.54263404774246 bayes_pls_golite062009
ATPase activity, coupled 0.527748436977659 bayes_pls_golite062009
single-stranded DNA binding 0.44104272460881 bayes_pls_golite062009
cell surface binding 0.326492680678891 bayes_pls_golite062009
peptide hormone binding 0.280457039468896 bayes_pls_golite062009
ion transmembrane transporter activity 0.280310103153739 bayes_pls_golite062009
active transmembrane transporter activity 0.275534581026027 bayes_pls_golite062009
primary active transmembrane transporter activity 0.252704226951294 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.243984617084631 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.205808843369749 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.202279803135899 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.20198255686005 bayes_pls_golite062009
catalytic activity 0.107125378994589 bayes_pls_golite062009
cation transmembrane transporter activity 0.0778814959589007 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle