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Protein Overview: rdgA-PA

General Information:
Name(s) found: rdgA-PA / FBpp0291800 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene retinal degeneration A is referred to in FlyBase by the symbol Dmel\rdgA (CG42667, FBgn0261549). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:8801101..8919841. It has the cytological map location 8B8-8C3. Based on sequence similarity, it is predicted to have molecular function</span>: diacylglycerol binding; diacylglycerol kinase activity. There is experimental evidence that it is involved in the biological process</span>: rhodopsin mediated signaling pathway; phototransduction; deactivation of rhodopsin mediated signaling; thermotaxis; actin filament organization. 54 alleles are reported. The phenotypes of these alleles are annotated with 26 unique terms, many of which group under: external compound sense organ; peripheral nervous system; nervous system; compound cell cluster organ; integumentary plate; rhabdomere R7; rhabdomere; adult segment; cell projection; multi-cell-component structure. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1457 amino acids

    Gene Ontology:
    Cellular Component: membrane [NAS]
    Biological Process: actin filament organization [IMP]
    phosphoinositide biosynthetic process [TAS]
    visual perception [NAS]
    activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway [IEA]
    phototransduction [IMP][TAS]
    lipid phosphorylation [TAS]
    phosphatidic acid biosynthetic process [TAS]
    intracellular signaling pathway [IEA]
    thermotaxis [IDA]
    photoreceptor cell maintenance [NAS][TAS]
    rhodopsin mediated signaling pathway [IMP]
    phosphorylation [NAS]
    deactivation of rhodopsin mediated signaling [IGI]
    Molecular Function: diacylglycerol binding [ISS][NAS]
    diacylglycerol kinase activity [ISS][NAS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQQQQQPSID QLPEPTASTS NSATTKPTIA TATTSTTTTS GNNFHQQLQA TTAATMQRLR  60
   61 TTFTRSRTPT GAEMKMQNSL EVPKQVRSAS FDEMQLESQR ASSSLLKQQS SSSASADERS 120
  121 SEAGFLQVPL AAHQQRSHSF DSATASAGSD DSGTFLEVPR RLKARRSSST KTPPPCIHCH 180
  181 YLEEYERRMT AEQRYFIDHR ELTALSYSNT SSEASEDEDE VEGHNAEEEE EGSAAIEDAE 240
  241 EETTEAATEE ADEDPRTEVE SEHDHDPDDD AALEMDIRIG NMSQGSSIEE SRARLPRQMR 300
  301 RHTIGSSSVT SASEDEGLEG SDNGSPHFGN TLLPPQPTTP CGITFTLSPT NGDYPSPPHL 360
  361 PLDPGSPPIS PCSSNSGRLP ALAPIISTPC SSADADDAGA AMGLPVRARR RSISRQEAIF 420
  421 VEPTGNSLEN VSHEEVDNSN TKSSVDTADS LDEASTMATC GSPGAAGGSG ASSSHHNAFV 480
  481 VRDIYLMVPD LKRDRAASVD SCFSKLSSNA KTEELQPSAD GCFLTVPNIN ATRSRSVDIV 540
  541 LPTDEQARYK ALSMTGSTVT YADGRTASAS NSRRPIRIVP DWTENAVQGE HYWKPTSASG 600
  601 DLCCLNEECI KSGQRMKCSA CQLVAHHNCI PFVNEKSTLA CKPTYRDVGI RQYREQTTTH 660
  661 HHWVHRKLEK GKCKQCGKFF PMKQAVQSKL FGSKEIVALA CAWCHEIYHN KEACFNQAKI 720
  721 GEECRLGNYA PIIVPPSWIV KLPTKGNFKS SIRVSNKNNA ASGSGGGGAG GGAGGGGGKS 780
  781 KKQTQRRQKG KEEKKEPRAF IVKPIPSPEV IPVIVFINPK SGGNQGHKLL GKFQHLLNPR 840
  841 QVFDLTQGGP KMGLDMFRKA PNLRVLACGG DGTVGWVLSV LDQIQPPLQP APAVGVLPLG 900
  901 TGNDLARALG WGGGYTDEPI GKILREIGMS QCVLMDRWRV KVTPNDDVTD DHVDRSKPNV 960
  961 PLNVINNYFS FGVDAHIALE FHEAREAHPE RFNSRLRNKM YYGQMGGKDL ILRQYRNLSQ1020
 1021 WVTLECDGQD FTGKLRDAGC HAVLFLNIPS YGGGTHPWND SFGASKPSID DGLMEVVGLT1080
 1081 TYQLPMLQAG MHGTCICQCR KARIITKRTI PMQVDGEACR VKPSVIEIEL LNKALMLSKR1140
 1141 KHGRGDVQVN PLEKMQLHIL RVTMQQYEQY HYDKEMLRKL ANKLGQIEIE SQCDLEHVRN1200
 1201 MLNTKFEESI SYPKVSQDWC FIDSCTAEHY FRIDRAQEHL HYICDIAIDE LYILDHEAAT1260
 1261 MPQTPDQERS FAAFSQRQAQ NERRQMDQAQ GRGPGSTDED LQIGSKPIKV MKWKSPILEQ1320
 1321 TSDAILLAAQ SGDLNMLRAL HEQGYSLQSV NKNGQTALHF ACKYNHRDIV KYIIASATRR1380
 1381 LINMADKELG QTALHIAAEQ NRRDICVMLV AAGAHLDTLD SGGNTPMMVA FNKNANEIAT1440
 1441 YLESKQGTQP VDGWLDD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..236] deduced N/A No confident structure predictions are available.
    2 View Details [237..519] deduced N/A No confident structure predictions are available.
    3 View Details [520..723] PSI-BLAST 45.0 No description for 2i13A was found.
    4 View Details [724..808] PSI-BLAST 15.522879 Transcription factor IIIA, TFIIIA
    5 View Details [809..1093] FFAS03 4.33 No description for 2bonA was found.
    6 View Details [1094..1457] PSI-BLAST 84.522879 Ankyrin-R

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  3.10743787485868 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.9286072149962 bayes_pls_golite062009
  • DNA binding
    		•  2.91902554182176 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.79821688035927 bayes_pls_golite062009
  • transcription activator activity
    		•  2.18185767124518 bayes_pls_golite062009
  • protein binding
    		•  2.05530362750351 bayes_pls_golite062009
  • transcription factor activity
    		•  2.01262882344347 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.81101516804605 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.39839669257043 bayes_pls_golite062009
  • chromatin binding
    		•  1.30226466791538 bayes_pls_golite062009
  • receptor activity
    		•  1.18834908971961 bayes_pls_golite062009
  • transcription factor binding
    		•  1.1783268121342 bayes_pls_golite062009
  • signal transducer activity
    		•  1.12277938241964 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.12277938241964 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.10244758181399 bayes_pls_golite062009
  • catalytic activity
    		•  0.245893663605433 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.18282984873138 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.0163653634078658 bayes_pls_golite062009
    5
    Term Confidence Notes
  • kinase activity
    		•  2.59626926900313 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.35052368075833 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.2931296299501 bayes_pls_golite062009
  • transferase activity
    		•  1.54317668564469 bayes_pls_golite062009
  • lipid kinase activity
    		•  0.740851164429992 bayes_pls_golite062009
  • catalytic activity
    		•  0.342718239360125 bayes_pls_golite062009
    6
    Term Confidence Notes
  • protein binding
    		•  2.69918165732603 bayes_pls_golite062009
  • binding
    		•  2.60916417202222 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.2375987667709 bayes_pls_golite062009
  • signal transducer activity
    		•  1.2375987667709 bayes_pls_golite062009
  • receptor activity
    		•  1.22857731988464 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.1034434071611 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.10325771560525 bayes_pls_golite062009
  • kinase activity
    		•  0.973206891506661 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.954469238725827 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.876784788207113 bayes_pls_golite062009
  • transcription factor binding
    		•  0.84590123339816 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.74360198348535 bayes_pls_golite062009
  • protein kinase activity
    		•  0.663511836722598 bayes_pls_golite062009
  • enzyme binding
    		•  0.60140077251711 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.589753112911856 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.556885542399749 bayes_pls_golite062009
  • channel activity
    		•  0.556885542399749 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.5337972579854 bayes_pls_golite062009
  • ion channel activity
    		•  0.40517082975613 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.3210142108162 bayes_pls_golite062009
  • transferase activity
    		•  0.298084176742023 bayes_pls_golite062009
  • transcription activator activity
    		•  0.295016294965448 bayes_pls_golite062009
  • gated channel activity
    		•  0.28982824879439 bayes_pls_golite062009
  • cation channel activity
    		•  0.2321216453051 bayes_pls_golite062009
  • DNA binding
    		•  0.139886855398905 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.108244697820437 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.106792084948545 bayes_pls_golite062009
  • mechanically gated channel activity
    		•  0.0507470076143287 bayes_pls_golite062009
  • mechanically-gated ion channel activity
    		•  0.0507470076143287 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.0018080615624233 bayes_pls_golite062009
  • actin binding
    		•  6.04689889151855E-4 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle