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View Structure Prediction Details

Protein: rdgA-PA
Organism: Drosophila melanogaster
Length: 1457 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for rdgA-PA.

Description E-value Query
Range
Subject
Range
gi|113193588, gi... - gi|116007138|ref|NP_001036264.1| retinal degeneration A CG10966-PB, isoform B [Drosophila melanogast...
1393.0 [0..1] [1445..1]

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Predicted Domain #1
Region A:
Residues: [1-236]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQQQQQPSID QLPEPTASTS NSATTKPTIA TATTSTTTTS GNNFHQQLQA TTAATMQRLR  60
   61 TTFTRSRTPT GAEMKMQNSL EVPKQVRSAS FDEMQLESQR ASSSLLKQQS SSSASADERS 120
  121 SEAGFLQVPL AAHQQRSHSF DSATASAGSD DSGTFLEVPR RLKARRSSST KTPPPCIHCH 180
  181 YLEEYERRMT AEQRYFIDHR ELTALSYSNT SSEASEDEDE VEGHNAEEEE EGSAAI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [237-519]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDAEEETTEA ATEEADEDPR TEVESEHDHD PDDDAALEMD IRIGNMSQGS SIEESRARLP  60
   61 RQMRRHTIGS SSVTSASEDE GLEGSDNGSP HFGNTLLPPQ PTTPCGITFT LSPTNGDYPS 120
  121 PPHLPLDPGS PPISPCSSNS GRLPALAPII STPCSSADAD DAGAAMGLPV RARRRSISRQ 180
  181 EAIFVEPTGN SLENVSHEEV DNSNTKSSVD TADSLDEAST MATCGSPGAA GGSGASSSHH 240
  241 NAFVVRDIYL MVPDLKRDRA ASVDSCFSKL SSNAKTEELQ PSA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [520-723]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGCFLTVPNI NATRSRSVDI VLPTDEQARY KALSMTGSTV TYADGRTASA SNSRRPIRIV  60
   61 PDWTENAVQG EHYWKPTSAS GDLCCLNEEC IKSGQRMKCS ACQLVAHHNC IPFVNEKSTL 120
  121 ACKPTYRDVG IRQYREQTTT HHHWVHRKLE KGKCKQCGKF FPMKQAVQSK LFGSKEIVAL 180
  181 ACAWCHEIYH NKEACFNQAK IGEE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.0
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #4
Region A:
Residues: [724-808]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CRLGNYAPII VPPSWIVKLP TKGNFKSSIR VSNKNNAASG SGGGGAGGGA GGGGGKSKKQ  60
   61 TQRRQKGKEE KKEPRAFIVK PIPSP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.522879
Match: 1tf6A
Description: Transcription factor IIIA, TFIIIA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.10743787485868 bayes_pls_golite062009
transcription regulator activity 2.9286072149962 bayes_pls_golite062009
DNA binding 2.91902554182176 bayes_pls_golite062009
nucleic acid binding 2.79821688035927 bayes_pls_golite062009
transcription activator activity 2.18185767124518 bayes_pls_golite062009
protein binding 2.05530362750351 bayes_pls_golite062009
transcription factor activity 2.01262882344347 bayes_pls_golite062009
transcription repressor activity 1.81101516804605 bayes_pls_golite062009
sequence-specific DNA binding 1.39839669257043 bayes_pls_golite062009
chromatin binding 1.30226466791538 bayes_pls_golite062009
receptor activity 1.18834908971961 bayes_pls_golite062009
transcription factor binding 1.1783268121342 bayes_pls_golite062009
signal transducer activity 1.12277938241964 bayes_pls_golite062009
molecular transducer activity 1.12277938241964 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.10244758181399 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009
transcription corepressor activity 0.18282984873138 bayes_pls_golite062009
cytoskeletal protein binding 0.0163653634078658 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [809-1093]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EVIPVIVFIN PKSGGNQGHK LLGKFQHLLN PRQVFDLTQG GPKMGLDMFR KAPNLRVLAC  60
   61 GGDGTVGWVL SVLDQIQPPL QPAPAVGVLP LGTGNDLARA LGWGGGYTDE PIGKILREIG 120
  121 MSQCVLMDRW RVKVTPNDDV TDDHVDRSKP NVPLNVINNY FSFGVDAHIA LEFHEAREAH 180
  181 PERFNSRLRN KMYYGQMGGK DLILRQYRNL SQWVTLECDG QDFTGKLRDA GCHAVLFLNI 240
  241 PSYGGGTHPW NDSFGASKPS IDDGLMEVVG LTTYQLPMLQ AGMHG

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.33
Match: 2bonA
Description: No description for 2bonA was found.

Predicted functions:

Term Confidence Notes
kinase activity 2.59626926900313 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.35052368075833 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.2931296299501 bayes_pls_golite062009
transferase activity 1.54317668564469 bayes_pls_golite062009
lipid kinase activity 0.740851164429992 bayes_pls_golite062009
catalytic activity 0.342718239360125 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [1094-1457]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TCICQCRKAR IITKRTIPMQ VDGEACRVKP SVIEIELLNK ALMLSKRKHG RGDVQVNPLE  60
   61 KMQLHILRVT MQQYEQYHYD KEMLRKLANK LGQIEIESQC DLEHVRNMLN TKFEESISYP 120
  121 KVSQDWCFID SCTAEHYFRI DRAQEHLHYI CDIAIDELYI LDHEAATMPQ TPDQERSFAA 180
  181 FSQRQAQNER RQMDQAQGRG PGSTDEDLQI GSKPIKVMKW KSPILEQTSD AILLAAQSGD 240
  241 LNMLRALHEQ GYSLQSVNKN GQTALHFACK YNHRDIVKYI IASATRRLIN MADKELGQTA 300
  301 LHIAAEQNRR DICVMLVAAG AHLDTLDSGG NTPMMVAFNK NANEIATYLE SKQGTQPVDG 360
  361 WLDD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 84.522879
Match: 1n11A
Description: Ankyrin-R
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 2.69918165732603 bayes_pls_golite062009
binding 2.60916417202222 bayes_pls_golite062009
molecular transducer activity 1.2375987667709 bayes_pls_golite062009
signal transducer activity 1.2375987667709 bayes_pls_golite062009
receptor activity 1.22857731988464 bayes_pls_golite062009
cytoskeletal protein binding 1.1034434071611 bayes_pls_golite062009
transmembrane receptor activity 1.10325771560525 bayes_pls_golite062009
kinase activity 0.973206891506661 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.954469238725827 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.876784788207113 bayes_pls_golite062009
transcription factor binding 0.84590123339816 bayes_pls_golite062009
substrate-specific channel activity 0.74360198348535 bayes_pls_golite062009
protein kinase activity 0.663511836722598 bayes_pls_golite062009
enzyme binding 0.60140077251711 bayes_pls_golite062009
transcription regulator activity 0.589753112911856 bayes_pls_golite062009
passive transmembrane transporter activity 0.556885542399749 bayes_pls_golite062009
channel activity 0.556885542399749 bayes_pls_golite062009
enzyme regulator activity 0.5337972579854 bayes_pls_golite062009
ion channel activity 0.40517082975613 bayes_pls_golite062009
structural constituent of cytoskeleton 0.3210142108162 bayes_pls_golite062009
transferase activity 0.298084176742023 bayes_pls_golite062009
transcription activator activity 0.295016294965448 bayes_pls_golite062009
gated channel activity 0.28982824879439 bayes_pls_golite062009
cation channel activity 0.2321216453051 bayes_pls_golite062009
DNA binding 0.139886855398905 bayes_pls_golite062009
transcription repressor activity 0.108244697820437 bayes_pls_golite062009
nucleic acid binding 0.106792084948545 bayes_pls_golite062009
mechanically gated channel activity 0.0507470076143287 bayes_pls_golite062009
mechanically-gated ion channel activity 0.0507470076143287 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.0018080615624233 bayes_pls_golite062009
actin binding 6.04689889151855E-4 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle