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Protein Overview: gi|24640536, gi|...

General Information:
Name(s) found: gi|71153821 [NCBI NR]
gi|24640536 [NCBI NR]
gi|22831933 [NCBI NR]
gi|15554294 [NCBI NR]
Description(s) found:
Found 12 descriptions.
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  • gi|71153821|sp|Q95UN8.1|M3KSL_DROME RecName: Full=Mitogen-activated protein kinase kinase kinase; AltName: Full=Mixed lineage kinase; AltName: Full=dMLK; AltName: Full=Protein slipper [NCBI NR]
  • gi|24640536|ref|NP_572458.2| slipper CG2272-PA [Drosophila melanogaster] [NCBI NR]
  • gi|22831933|gb|AAF46344.2| CG2272-PA [Drosophila melanogaster] [NCBI NR]
  • gi|15554294|gb|AAK98795.1| mixed lineage protein kinase [Drosophila melanogaster] [NCBI NR]
    • Organism: Drosophila melanogaster
    Length: 1161 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: dorsal closure [IMP][TAS]
    imaginal disc fusion, thorax closure [IMP]
    positive regulation of JNK cascade [IMP]
    dorsal closure, elongation of leading edge cells [IMP]
    activation of JNKK activity [TAS]
    protein amino acid autophosphorylation [ISS]
    activation of JUN kinase activity [IMP][TAS]
    dorsal appendage formation [IMP]
    JNK cascade [IGI][IMP]
    protein amino acid phosphorylation [IDA][NAS]
    imaginal disc-derived female genitalia morphogenesis [IMP]
    imaginal disc-derived male genitalia morphogenesis [IMP]
    Molecular Function: ATP binding [IEA]
    protein tyrosine kinase activity [IEA]
    protein serine/threonine/tyrosine kinase activity [ISS]
    protein homodimerization activity [ISS]
    JUN kinase kinase kinase activity [IDA][ISS][NAS]
    protein kinase activity [IDA][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSQVSRGLD TTNMLPISEE QQLQQQQQQQ QLEQLHHPQI PEIPIPDLEQ VETQVGDGSL  60
   61 WTALYDYDAQ GEDELTLRRG EIVVVLSTDS EVSGDVGWWT GKIGDKVGVF PKDFVTDEDP 120
  121 LQLNVSSAIG DIQPHEIEYN ELDIKEVIGS GGFCKVHRGY YDGEEVAIKI AHQTGEDDMQ 180
  181 RMRDNVLQEA KLFWALKHEN IAALRGVCLN TKLCLVMEYA RGGSLNRILA GKIPPDVLVN 240
  241 WAIQIARGMN YLHNEAPMSI IHRDLKSSNV LIYEAIEGNH LQQKTLKITD FGLAREMYNT 300
  301 QRMSAAGTYA WMPPEVISVS TYSKFSDVWS YGVLLWELIT GETPYKGFDP LSVAYGVAVN 360
  361 TLTLPIPKTC PETWGALMKS CWQTDPHKRP GFKEILKQLE SIACSKFTLT PQESFHYMQE 420
  421 CWRKEIAGVL HDLREKEKEL RNKEEQLLRV QNEQREKANL LKIREQNLRE RERVLIEREL 480
  481 VMLQPVPSKR KHKKGKKNKP LQISLPTGFR HTITAVRDKA EQPGSPSFSG LRIVALTDGH 540
  541 KGKTWGPSTM HQRERSLLPS QLSGGQPEWP AQTSTHSSFS KSAPNLDKKQ QQQNQQQVAS 600
  601 LTPPPGLGIL GGSGGAGGTP ATPLLYPGIP IILTRPNNNN IGNCKAITTT ITTTTTTTTN 660
  661 NNNNNNNSIS ANNNNQLNNI STINSNNNNN QTNLTSQPNT IIVLQNGRNN SNSSTTSQSP 720
  721 AKIYHRARSQ EYGLDHPLAY QPPPLYLVTD DSSETDTVAS PTGCFHFLKS GNSSAASGAV 780
  781 HLHRFGGSLG NSPAVGRKKH SLDSSSHHPP ANGSNSFALP NQLTLPSEDN NTYDHAFYRD 840
  841 VIKKMSMASS ERVNSKSSGD LTMYNSSTPL TARDCDDAEE AFEGGRFQRN FSGSQFPRHC 900
  901 FFTRQEEEGE AEDEDAVAAE VDTADADADD ECQVPASQMR QNSTTSRKSS VTFQSVSFEE 960
  961 PDFVATPRTT ARSDLYTSSA SISFATYRSA SPSLSSSSTT ASASPSIAST EAVNGYHMQE1020
 1021 NSILNTRRMQ DVQPHPDVIK LRAQEQRQQT KNQKKQRPKH ITKSKSVEAP VEGQHHEHDD1080
 1081 HNDPQHQHHS AGSSKIRALF NLFTRSRKKY SKLAEHNMVG GPEFCAIDPY QTDLAMGGSS1140
 1141 RSLKRKGKKP QTQSCEQLER C

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..409] PSI-BLAST 92.39794 CHICKEN SRC TYROSINE KINASE
    2 View Details [410..553] PSI-BLAST 48.0 TWITCHIN KINASE FRAGMENT (C.ELEGANS), AUTOREGULATED PROTEIN KINASE AND IMMUNOGLOBULIN DOMAINS
    3 View Details [554..614] deduced N/A No confident structure predictions are available.
    4 View Details [615..734] deduced N/A No confident structure predictions are available.
    5 View Details [735..896] deduced N/A No confident structure predictions are available.
    6 View Details [897..1082] MSA 2.279994 View MSA. No confident structure predictions are available.
    7 View Details [1083..1161] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein kinase activity
    		•  5.63683237027974 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.24105099841813 bayes_pls_golite062009
  • kinase activity
    		•  5.02394449930162 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.38615595541751 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.33927583810751 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  3.41480681854114 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • transferase activity
    		•  3.26787750561728 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  2.9751846707539 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.59526003830791 bayes_pls_golite062009
  • signal transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • receptor activity
    		•  2.39311927684508 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • binding
    		•  2.10874590528357 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.81145713371725 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine kinase activity
    		•  1.66669268613198 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • vinculin binding
    		•  1.63216315345235 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.59474164216385 bayes_pls_golite062009
  • growth factor binding
    		•  1.53863828216563 bayes_pls_golite062009
  • kinase binding
    		•  1.26086833316556 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.25285260301349 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  1.10045286406485 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  1.10045286406485 bayes_pls_golite062009
  • protein kinase binding
    		•  1.06030596516506 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.777367738889091 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.75189004129952 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  0.74324450025139 bayes_pls_golite062009
  • transporter activity
    		•  0.710766490066447 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.60324822483033 bayes_pls_golite062009
  • activin binding
    		•  0.510364757301021 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.385603245903806 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.371991354471077 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.310771535422373 bayes_pls_golite062009
  • enzyme binding
    		•  0.268058321307564 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • insulin receptor activity
    		•  0.188254408239569 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.152203945257581 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.0675236791909441 bayes_pls_golite062009
  • sevenless binding
    		•  0.0591955406382375 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.0506751594607393 bayes_pls_golite062009
  • JUN kinase kinase kinase kinase activity
    		•  0.0393215018817107 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle