Protein Overview: N-PA, FBpp0293201

General Information:
Name(s) found:	FBpp0293201 [FlyBase] N-PA / FBpp0070483 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|24639454\|ref\|NP_476859.2\| notch [Drosophila melanogaster] [NCBI NR] gi\|17380387\|sp\|P07207.3\|NOTCH_DROME RecName: Full=Neurogenic locus Notch protein; Contains: RecName: Full=Processed neurogenic locus Notch protein; Flags: Precursor [NCBI NR] gi\|10728440\|gb\|AAF45848.2\| notch [Drosophila melanogaster] [NCBI NR] (P07207) Neurogenic locus Notch protein precursor [Swiss-Prot] Neurogenic locus Notch protein OS=Drosophila melanogaster GN=N PE=1 SV=3 [Swiss-Prot] type=protein; loc=X:join(3029701..3029860,3042008..3042098,3049960..3050222,3050293..3050497,3053136..3053266,3057512..3063660,3063755..3064064,3064137..3064592,3064668..3065014); ID=FBpp0293201; name=N-PB; parent=FBgn0004647,FBtr0304659; dbxref=REFSEQ:NP_001245510,GB_protein:AFH07224,FlyBase:FBpp0293201,FlyBase_Annotation_IDs:CG3936-PB; MD5=eb325d68765649f3755c5a72e1db32ce; length=2703; release=r5.56; species=Dmel; [FlyBase] The gene Notch is referred to in FlyBase by the symbol Dmel\N (CG3936, FBgn0004647). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:3028905..3066295. It has the cytological map location 3C7-3C9. There is experimental evidence that it has the molecular function</span>: protein binding; specific transcriptional repressor activity; transcription activator activity. There is experimental evidence for 52 unique biological process</span> terms, many of which group under: anatomical structure development; reproductive process in a multicellular organism; organ development; sensory organ development; organ morphogenesis; regulation of developmental process; regulation of neurogenesis; cellular component movement; ovarian follicle cell development; stem cell differentiation. 649 alleles are reported. The phenotypes of these alleles are annotated with 215 unique terms, many of which group under: adult segment; peripheral nervous system; organ system; nervous system; adult mesothoracic segment; embryonic nervous system; external compound sense organ; multi-cell-component structure; primordium; late extended germ band embryo. It has one annotated transcript and one annotated polypeptide. [FlyBase] >CG3936-PA translation from_gene[CG3936 N FBgn0004647] seq_release:3 mol_weight=288855 cds_boundaries:(X:2,894,106..2,929,416[+]) aa_length:2703 transcript_info:[CG3936-RA seq_release:3] gene_info:[gene symbol:N FBgn0004647 gene_boundaries:(X:2,893,310 [hmr_yeast5_DM3-1_pombe.fasta] (AE003426) N gene product [Drosophila melanogaster] [yeastflysequest.fasta] CG3936-PA [Drosophila melanogaster]gi\|24639454\|ref\|NP_476859.2\| CG3936-PA [Drosophila melanogaster]gi\|17380387\|sp\|P07207\|NOTC_DROME Neurogenic locus Notch protein precursor [nrdb_11152004_Chlamydomonas] type=protein; loc=X:join(3029701..3029860,3042008..3042098,3049960..3050222,3050293..3050497,3053136..3053266,3057512..3063660,3063755..3064064,3064137..3064592,3064668..3065014); ID=FBpp0070483; name=N-PA; parent=FBgn0004647,FBtr0070507; dbxref=FlyBase:F [fly-100309-contam.fasta] Notch CG3936-PA [Drosophila melanogaster] [nr-271106-contam.fasta] CG3936-PA [Drosophila melanogaster] [nr-271106-contam.fasta] Neurogenic locus Notch protein precursor [nr-271106-contam.fasta] type=protein; loc=X:join(3029701..3029860,3042008..3042098,3049960..3050222,3050293..3050497,3053136..3053266,3057512..3063660,3063755..3064064,3064137..3064592,3064668..3065014); ID=FBpp0070483; name=N-PA; parent=FBgn0004647,FBtr0070507; dbxref=FlyBase:FBpp0070483,FlyBase_Annotation_IDs:CG3936-PA,GB_protein:AAF45848.2,REFSEQ:NP_476859,GB_protein:AAF45848; MD5=eb325d68765649f3755c5a72e1db32ce; length=2703; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=X:join(3029701..3029860,3042008..3042098,3049960..3050222,3050293..3050497,3053136..3053266,3057512..3063660,3063755..3064064,3064137..3064592,3064668..3065014); ID=FBpp0070483; name=N-PA; parent=FBgn0004647,FBtr0070507; dbxref=FlyBase:FBpp0070483,FlyBase_Annotation_IDs:CG3936-PA,GB_protein:AAF45848.2,REFSEQ:NP_476859,GB_protein:AAF45848; MD5=eb325d68765649f3755c5a72e1db32ce; length=2703; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=X:join(3029701..3029860,3042008..3042098,3049960..3050222,3050293..3050497,3053136..3053266,3057512..3063660,3063755..3064064,3064137..3064592,3064668..3065014); ID=FBpp0070483; name=N-PA; parent=FBgn0004647,FBtr0070507; dbxref=FlyBase:FBpp0070483,FlyBase_Annotation_IDs:CG3936-PA,GB_protein:AAF45848.2,REFSEQ:NP_476859,GB_protein:AAF45848,FlyMine:FBpp0070483,modMine:FBpp0070483; MD5=eb325d68765649f3755c5a72e1db32ce; length=2703; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=X:join(3029701..3029860,3042008..3042098,3049960..3050222,3050293..3050497,3053136..3053266,3057512..3063660,3063755..3064064,3064137..3064592,3064668..3065014); ID=FBpp0293201; name=N-PB; parent=FBgn0004647,FBtr0304659; dbxref=REFSEQ:NP_001245510,GB_protein:AFH07224,FlyBase:FBpp0293201,FlyBase_Annotation_IDs:CG3936-PB; MD5=eb325d68765649f3755c5a72e1db32ce; length=2703; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=X:join(3135668..3135827,3147975..3148065,3155927..3156189,3156260..3156464,3159103..3159233,3163479..3169627,3169722..3170031,3170104..3170559,3170635..3170981); ID=FBpp0070483; name=N-PA; parent=FBgn0004647,FBtr0070507; dbxref=FlyBase:FBpp0070483,FlyBase_Annotation_IDs:CG3936-PA,GB_protein:AAF45848.2,REFSEQ:NP_476859,GB_protein:AAF45848,FlyMine:FBpp0070483,modMine:FBpp0070483; MD5=eb325d68765649f3755c5a72e1db32ce; length=2703; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=X:join(3135668..3135827,3147975..3148065,3155927..3156189,3156260..3156464,3159103..3159233,3163479..3169627,3169722..3170031,3170104..3170559,3170635..3170981); ID=FBpp0293201; name=N-PB; parent=FBgn0004647,FBtr0304659; dbxref=REFSEQ:NP_001245510,GB_protein:AFH07224,FlyBase:FBpp0293201,FlyBase_Annotation_IDs:CG3936-PB; MD5=eb325d68765649f3755c5a72e1db32ce; length=2703; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=X:join(3135668..3135827,3147975..3148065,3155927..3156189,3156260..3156464,3159103..3159233,3163479..3169627,3169722..3170031,3170104..3170559,3170635..3170981); ID=FBpp0070483; name=N-PA; parent=FBgn0004647,FBtr0070507; dbxref=FlyBase:FBpp0070483,FlyBase_Annotation_IDs:CG3936-PA,GB_protein:AAF45848.2,REFSEQ:NP_476859,GB_protein:AAF45848,FlyMine:FBpp0070483,modMine:FBpp0070483; MD5=eb325d68765649f3755c5a72e1db32ce; length=2703; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] type=protein; loc=X:join(3135668..3135827,3147975..3148065,3155927..3156189,3156260..3156464,3159103..3159233,3163479..3169627,3169722..3170031,3170104..3170559,3170635..3170981); ID=FBpp0293201; name=N-PB; parent=FBgn0004647,FBtr0304659; dbxref=REFSEQ:NP_001245510,GB_protein:AFH07224,FlyBase:FBpp0293201,FlyBase_Annotation_IDs:CG3936-PB; MD5=eb325d68765649f3755c5a72e1db32ce; length=2703; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] Isoform of P07207, Notch, isoform B OS=Drosophila melanogaster GN=N PE=1 SV=1 [DROME.fasta.20160308] FBpp0070483 type=protein; loc=X:join(3135668..3135827,3147975..3148065,3155927..3156189,3156260..3156464,3159103..3159233,3163479..3169627,3169722..3170031,3170104..3170559,3170635..3170981); ID=FBpp0070483; name=N-PA; parent=FBgn0004647,FBtr0070507; dbxref=FlyBase:FBpp0070483,FlyBase_Annotation_IDs:CG3936-PA,GB_protein:AAF45848.2,REFSEQ:NP_476859,GB_protein:AAF45848,FlyMine:FBpp0070483,modMine:FBpp0070483; MD5=eb325d68765649f3755c5a72e1db32ce; length=2703; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] FBpp0293201 type=protein; loc=X:join(3135668..3135827,3147975..3148065,3155927..3156189,3156260..3156464,3159103..3159233,3163479..3169627,3169722..3170031,3170104..3170559,3170635..3170981); ID=FBpp0293201; name=N-PB; parent=FBgn0004647,FBtr0304659; dbxref=REFSEQ:NP_001245510,GB_protein:AFH07224,FlyBase:FBpp0293201,FlyBase_Annotation_IDs:CG3936-PB; MD5=eb325d68765649f3755c5a72e1db32ce; length=2703; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=X:join(3135668..3135827,3147975..3148065,3155927..3156189,3156260..3156464,3159103..3159233,3163479..3169627,3169722..3170031,3170104..3170559,3170635..3170981); ID=FBpp0070483; name=N-PA; parent=FBgn0004647,FBtr0070507; dbxref=FlyBase:FBpp0070483,FlyBase_Annotation_IDs:CG3936-PA,GB_protein:AAF45848.2,REFSEQ:NP_476859,GB_protein:AAF45848,UniProt/Swiss-Prot:P07207,FlyMine:FBpp0070483,modMine:FBpp0070483; MD5=eb325d68765649f3755c5a72e1db32ce; length=2703; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta] type=protein; loc=X:join(3135668..3135827,3147975..3148065,3155927..3156189,3156260..3156464,3159103..3159233,3163479..3169627,3169722..3170031,3170104..3170559,3170635..3170981); ID=FBpp0293201; name=N-PB; parent=FBgn0004647,FBtr0304659; dbxref=REFSEQ:NP_001245510,GB_protein:AFH07224,FlyBase:FBpp0293201,FlyBase_Annotation_IDs:CG3936-PB,UniProt/Swiss-Prot:P07207; MD5=eb325d68765649f3755c5a72e1db32ce; length=2703; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	2703 amino acids
Gene Ontology:
Cellular Component:	integral to plasma membrane [NAS] nucleus [NAS][TAS] adherens junction [IDA] subapical complex [IDA] integral to membrane [IEA][TAS] cytoplasmic vesicle [IDA] protein complex [IPI] intracellular [IDA][NAS] plasma membrane [IDA]
Biological Process:	leg segmentation [IMP] embryonic crystal cell differentiation [TAS] germarium-derived egg chamber formation [IMP][TAS] larval lymph gland hemopoiesis [IMP] dorsal/ventral pattern formation, imaginal disc [TAS] dorsal/ventral lineage restriction, imaginal disc [TAS] embryonic hemopoiesis [IMP] ovarian follicle cell migration [IMP] mesoderm development [IMP] anterior/posterior pattern formation [TAS] germarium-derived female germ-line cyst encapsulation [TAS] axon guidance [IMP] imaginal disc-derived wing margin morphogenesis [IMP] actin filament organization [IMP] border follicle cell migration [IMP] glial cell migration [IMP] compound eye morphogenesis [IMP] ovarian follicle cell development [IMP][TAS] second mitotic wave during compound eye morphogenesis [NAS] cell fate specification [NAS][TAS] morphogenesis of follicular epithelium [NAS] leg joint morphogenesis [IMP] negative regulation of terminal cell fate specification, open tracheal system [TAS] negative regulation of fusion cell fate specification [TAS] R8 cell fate commitment [TAS] epithelial cell type specification, open tracheal system [IMP] retinal cell programmed cell death [TAS] peripheral nervous system development [IMP][TAS] establishment of ommatidial planar polarity [NAS][TAS] compound eye retinal cell programmed cell death [TAS] asymmetric cell division [TAS] R3/R4 cell fate commitment [NAS] regulation of growth [IGI][IMP] sensory organ development [IMP] regulation of mitotic cell cycle [TAS] open tracheal system development [TAS] long-term memory [IGI][IMP][TAS] ventral cord development [NAS] Notch signaling pathway [NAS] [NOT]anesthesia-resistant memory [IMP] R8 cell development [TAS] sensory organ precursor cell fate determination [IMP] negative regulation of neurogenesis [IMP] R1/R6 cell differentiation [IMP] regulation of neurogenesis [IMP] dorsal closure [TAS] wing disc proximal/distal pattern formation [TAS] positive regulation of cell proliferation [IMP] imaginal disc-derived wing morphogenesis [IMP][NAS] heterophilic cell-cell adhesion [IDA][IMP] regulation of R8 cell spacing in compound eye [NAS] cell adhesion [TAS] R8 cell differentiation [NAS] imaginal disc-derived wing vein specification [IMP] ectoderm development [TAS] R7 cell differentiation [IMP][TAS] compound eye cone cell fate commitment [TAS] positive regulation of Notch signaling pathway [IMP] leg disc morphogenesis [TAS] oocyte anterior/posterior axis specification [TAS] negative regulation of transcription from RNA polymerase II promoter [TAS] response to symbiont [IMP] stem cell differentiation [IMP] positive regulation of S phase of mitotic cell cycle [IMP] lymph gland development [IMP] positive regulation of gene-specific transcription from RNA polymerase II promoter [IDA] eye-antennal disc development [IMP] oocyte localization during germarium-derived egg chamber formation [IMP] hemocyte proliferation [IMP] foregut morphogenesis [IMP] muscle cell fate determination [IMP] dorsal appendage formation [IMP] lymph gland crystal cell differentiation [TAS] lamellocyte differentiation [IMP] neuron development [IMP] imaginal disc pattern formation [TAS] glial cell fate determination [IMP] negative regulation of JNK cascade [NAS] regulation of cardioblast cell fate specification [IMP] compound eye development [NAS][TAS] crystal cell differentiation [IMP] imaginal disc growth [TAS] regulation of crystal cell differentiation [TAS] negative regulation of compound eye photoreceptor development [IMP] bristle morphogenesis [IMP] ovarian follicle cell stalk formation [IMP][TAS] oogenesis [IMP] skeletal muscle tissue development [IMP] germ-line stem cell maintenance [IMP] cell fate commitment [NAS] lateral inhibition [NAS][TAS] [NOT]establishment of imaginal disc-derived wing hair orientation [NAS] wing disc dorsal/ventral pattern formation [IMP] glial cell differentiation [IMP]
Molecular Function:	transmembrane receptor activity [NAS][TAS] protein binding [IPI] calcium ion binding [IEA] transcription activator activity [IDA][NAS] receptor activity [NAS][TAS] specific transcriptional repressor activity [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQSQRSRRRS RAPNTWICFW INKMHAVASL PASLPLLLLT LAFANLPNTV RGTDTALVAA  60
   61 SCTSVGCQNG GTCVTQLNGK TYCACDSHYV GDYCEHRNPC NSMRCQNGGT CQVTFRNGRP 120
  121 GISCKCPLGF DESLCEIAVP NACDHVTCLN GGTCQLKTLE EYTCACANGY TGERCETKNL 180
  181 CASSPCRNGA TCTALAGSSS FTCSCPPGFT GDTCSYDIEE CQSNPCKYGG TCVNTHGSYQ 240
  241 CMCPTGYTGK DCDTKYKPCS PSPCQNGGIC RSNGLSYECK CPKGFEGKNC EQNYDDCLGH 300
  301 LCQNGGTCID GISDYTCRCP PNFTGRFCQD DVDECAQRDH PVCQNGATCT NTHGSYSCIC 360
  361 VNGWAGLDCS NNTDDCKQAA CFYGATCIDG VGSFYCQCTK GKTGLLCHLD DACTSNPCHA 420
  421 DAICDTSPIN GSYACSCATG YKGVDCSEDI DECDQGSPCE HNGICVNTPG SYRCNCSQGF 480
  481 TGPRCETNIN ECESHPCQNE GSCLDDPGTF RCVCMPGFTG TQCEIDIDEC QSNPCLNDGT 540
  541 CHDKINGFKC SCALGFTGAR CQINIDDCQS QPCRNRGICH DSIAGYSCEC PPGYTGTSCE 600
  601 ININDCDSNP CHRGKCIDDV NSFKCLCDPG YTGYICQKQI NECESNPCQF DGHCQDRVGS 660
  661 YYCQCQAGTS GKNCEVNVNE CHSNPCNNGA TCIDGINSYK CQCVPGFTGQ HCEKNVDECI 720
  721 SSPCANNGVC IDQVNGYKCE CPRGFYDAHC LSDVDECASN PCVNEGRCED GINEFICHCP 780
  781 PGYTGKRCEL DIDECSSNPC QHGGTCYDKL NAFSCQCMPG YTGQKCETNI DDCVTNPCGN 840
  841 GGTCIDKVNG YKCVCKVPFT GRDCESKMDP CASNRCKNEA KCTPSSNFLD FSCTCKLGYT 900
  901 GRYCDEDIDE CSLSSPCRNG ASCLNVPGSY RCLCTKGYEG RDCAINTDDC ASFPCQNGGT 960
  961 CLDGIGDYSC LCVDGFDGKH CETDINECLS QPCQNGATCS QYVNSYTCTC PLGFSGINCQ1020
 1021 TNDEDCTESS CLNGGSCIDG INGYNCSCLA GYSGANCQYK LNKCDSNPCL NGATCHEQNN1080
 1081 EYTCHCPSGF TGKQCSEYVD WCGQSPCENG ATCSQMKHQF SCKCSAGWTG KLCDVQTISC1140
 1141 QDAADRKGLS LRQLCNNGTC KDYGNSHVCY CSQGYAGSYC QKEIDECQSQ PCQNGGTCRD1200
 1201 LIGAYECQCR QGFQGQNCEL NIDDCAPNPC QNGGTCHDRV MNFSCSCPPG TMGIICEINK1260
 1261 DDCKPGACHN NGSCIDRVGG FECVCQPGFV GARCEGDINE CLSNPCSNAG TLDCVQLVNN1320
 1321 YHCNCRPGHM GRHCEHKVDF CAQSPCQNGG NCNIRQSGHH CICNNGFYGK NCELSGQDCD1380
 1381 SNPCRVGNCV VADEGFGYRC ECPRGTLGEH CEIDTLDECS PNPCAQGAAC EDLLGDYECL1440
 1441 CPSKWKGKRC DIYDANYPGW NGGSGSGNDR YAADLEQQRA MCDKRGCTEK QGNGICDSDC1500
 1501 NTYACNFDGN DCSLGINPWA NCTANECWNK FKNGKCNEEC NNAACHYDGH DCERKLKSCD1560
 1561 SLFDAYCQKH YGDGFCDYGC NNAECSWDGL DCENKTQSPV LAEGAMSVVM LMNVEAFREI1620
 1621 QAQFLRNMSH MLRTTVRLKK DALGHDIIIN WKDNVRVPEI EDTDFARKNK ILYTQQVHQT1680
 1681 GIQIYLEIDN RKCTECFTHA VEAAEFLAAT AAKHQLRNDF QIHSVRGIKN PGDEDNGEPP1740
 1741 ANVKYVITGI ILVIIALAFF GMVLSTQRKR AHGVTWFPEG FRAPAAVMSR RRRDPHGQEM1800
 1801 RNLNKQVAMQ SQGVGQPGAH WSDDESDMPL PKRQRSDPVS GVGLGNNGGY ASDHTMVSEY1860
 1861 EEADQRVWSQ AHLDVVDVRA IMTPPAHQDG GKHDVDARGP CGLTPLMIAA VRGGGLDTGE1920
 1921 DIENNEDSTA QVISDLLAQG AELNATMDKT GETSLHLAAR FARADAAKRL LDAGADANCQ1980
 1981 DNTGRTPLHA AVAADAMGVF QILLRNRATN LNARMHDGTT PLILAARLAI EGMVEDLITA2040
 2041 DADINAADNS GKTALHWAAA VNNTEAVNIL LMHHANRDAQ DDKDETPLFL AAREGSYEAC2100
 2101 KALLDNFANR EITDHMDRLP RDVASERLHH DIVRLLDEHV PRSPQMLSMT PQAMIGSPPP2160
 2161 GQQQPQLITQ PTVISAGNGG NNGNGNASGK QSNQTAKQKA AKKAKLIEGS PDNGLDATGS2220
 2221 LRRKASSKKT SAASKKAANL NGLNPGQLTG GVSGVPGVPP TNSAAQAAAA AAAAVAAMSH2280
 2281 ELEGSPVGVG MGGNLPSPYD TSSMYSNAMA APLANGNPNT GAKQPPSYED CIKNAQSMQS2340
 2341 LQGNGLDMIK LDNYAYSMGS PFQQELLNGQ GLGMNGNGQR NGVGPGVLPG GLCGMGGLSG2400
 2401 AGNGNSHEQG LSPPYSNQSP PHSVQSSLAL SPHAYLGSPS PAKSRPSLPT SPTHIQAMRH2460
 2461 ATQQKQFGGS NLNSLLGGAN GGGVVGGGGG GGGGVGQGPQ NSPVSLGIIS PTGSDMGIML2520
 2521 APPQSSKNSA IMQTISPQQQ QQQQQQQQQQ HQQQQQQQQQ QQQQQQQQLG GLEFGSAGLD2580
 2581 LNGFCGSPDS FHSGQMNPPS IQSSMSGSSP STNMLSPSSQ HNQQAFYQYL TPSSQHSGGH2640
 2641 TPQHLVQTLD SYPTPSPESP GHWSSSSPRS NSDWSEGVQS PAANNLYISG GHQANKGSEA2700
 2701 IYI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: N-PA, FBpp0293201

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: