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Protein Overview: FBpp0310165, Roc...

General Information:
Name(s) found: FBpp0310165 [FlyBase]
Roc1a-PA / FBpp0070117 [FlyBase]
Description(s) found:
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  • gi|7290070|gb|AAF45536.1| Roc1a, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|37538005|sp|Q9W5E1.1|RBX1A_DROME RecName: Full=RING-box protein 1A; AltName: Full=Regulator of cullins 1a; AltName: Full=dRbx1 [NCBI NR]
  • gi|21430894|gb|AAM51125.1| SD23839p [Drosophila melanogaster] [NCBI NR]
  • gi|18543187|ref|NP_569852.1| Roc1a, isoform A [Drosophila melanogaster] [NCBI NR]
  • (Q9W5E1) RING-box protein 1A (Regulator of cullins 1a) (dRbx1) [Swiss-Prot]
  • RING-box protein 1A OS=Drosophila melanogaster GN=Roc1a PE=1 SV=1 [Swiss-Prot]
  • type=protein; loc=X:join(541481..541558,541643..541670,541736..541956); ID=FBpp0310165; name=Roc1a-PD; parent=FBgn0025638,FBtr0343564; dbxref=FlyBase:FBpp0310165,FlyBase_Annotation_IDs:CG16982-PD; MD5=0b2b0eb7e4a53b7bc0514af4a08964da; length=108; release=r5.56; species=Dmel; [FlyBase]
  • The gene Roc1a is referred to in FlyBase by the symbol Dmel\Roc1a (CG16982, FBgn0025638). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:541320..542636. It has the cytological map location 1B13. There is experimental evidence that it has the molecular function</span>: ubiquitin-protein ligase activity. There is experimental evidence that it is involved in the biological process</span>: smoothened signaling pathway; cell proliferation; proteolysis; protein ubiquitination. 9 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • >CG16982-PA translation from_gene[CG16982 Roc1a FBgn0025638] seq_release:3 mol_weight=12538 cds_boundaries:(X:404,885..405,357[+]) aa_length:108 transcript_info:[CG16982-RA seq_release:3] gene_info:[gene symbol:Roc1a FBgn0025638 gene_boundaries:(X:404, [hmr_yeast5_DM3-1_pombe.fasta]
  • (AE003418) EG:115C2.11 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG16982-PA [Drosophila melanogaster]gi|21430894|gb|AAM51125.1| SD23839p [Drosophila melanogaster]gi|18543187|ref|NP_569852.1| CG16982-PA [Drosophila melanogaster]gi|37538005|sp|Q9W5E1|RBXA_DROME RING-box protein 1A (Regulator of cullins 1a) (dRbx1) [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=X:join(541481..541558,541643..541670,541736..541956); ID=FBpp0070117; name=Roc1a-PA; parent=FBgn0025638,FBtr0070122; dbxref=FlyBase_Annotation_IDs:CG16982-PA,FlyBase:FBpp0070117,REFSEQ:NP_569852,GB_protein:AAF45536; MD5=0b2b0eb7e4a53b7bc [fly-100309-contam.fasta]
  • RING-box protein 1A (Regulator of cullins 1a) (dRbx1) [nr-271106-contam.fasta]
  • CG16982-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • SD23839p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Roc1a CG16982-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=X:join(541481..541558,541643..541670,541736..541956); ID=FBpp0070117; name=Roc1a-PA; parent=FBgn0025638,FBtr0070122; dbxref=FlyBase_Annotation_IDs:CG16982-PA,FlyBase:FBpp0070117,REFSEQ:NP_569852,GB_protein:AAF45536; MD5=0b2b0eb7e4a53b7bc0514af4a08964da; length=108; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:join(541481..541558,541643..541670,541736..541956); ID=FBpp0070117; name=Roc1a-PA; parent=FBgn0025638,FBtr0070122; dbxref=FlyBase_Annotation_IDs:CG16982-PA,FlyBase:FBpp0070117,GB_protein:AAF45536,REFSEQ:NP_569852; MD5=0b2b0eb7e4a53b7bc0514af4a08964da; length=108; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=X:join(541481..541558,541643..541670,541736..541956); ID=FBpp0070117; name=Roc1a-PA; parent=FBgn0025638,FBtr0070122; dbxref=FlyBase_Annotation_IDs:CG16982-PA,FlyBase:FBpp0070117,GB_protein:AAF45536,REFSEQ:NP_569852,FlyMine:FBpp0070117,modMine:FBpp0070117; MD5=0b2b0eb7e4a53b7bc0514af4a08964da; length=108; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=X:join(647448..647525,647610..647637,647703..647923); ID=FBpp0070117; name=Roc1a-PA; parent=FBgn0025638,FBtr0070122; dbxref=FlyBase_Annotation_IDs:CG16982-PA,FlyBase:FBpp0070117,GB_protein:AAF45536,REFSEQ:NP_569852,FlyMine:FBpp0070117,modMine:FBpp0070117; MD5=0b2b0eb7e4a53b7bc0514af4a08964da; length=108; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:join(647448..647525,647610..647637,647703..647923); ID=FBpp0310165; name=Roc1a-PD; parent=FBgn0025638,FBtr0343564; dbxref=GB_protein:AHN59225,REFSEQ:NP_001284754,FlyBase:FBpp0310165,FlyBase_Annotation_IDs:CG16982-PD; MD5=0b2b0eb7e4a53b7bc0514af4a08964da; length=108; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:join(647448..647525,647610..647637,647703..647923); ID=FBpp0070117; name=Roc1a-PA; parent=FBgn0025638,FBtr0070122; dbxref=FlyBase_Annotation_IDs:CG16982-PA,FlyBase:FBpp0070117,GB_protein:AAF45536,REFSEQ:NP_569852,FlyMine:FBpp0070117,modMine:FBpp0070117; MD5=0b2b0eb7e4a53b7bc0514af4a08964da; length=108; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • type=protein; loc=X:join(647448..647525,647610..647637,647703..647923); ID=FBpp0310165; name=Roc1a-PD; parent=FBgn0025638,FBtr0343564; dbxref=GB_protein:AHN59225,REFSEQ:NP_001284754,FlyBase:FBpp0310165,FlyBase_Annotation_IDs:CG16982-PD; MD5=0b2b0eb7e4a53b7bc0514af4a08964da; length=108; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of Q9W5E1, Regulator of cullins 1a, isoform D OS=Drosophila melanogaster GN=Roc1a PE=4 SV=1 [DROME.fasta.20160308]
  • FBpp0070117 type=protein; loc=X:join(647448..647525,647610..647637,647703..647923); ID=FBpp0070117; name=Roc1a-PA; parent=FBgn0025638,FBtr0070122; dbxref=FlyBase_Annotation_IDs:CG16982-PA,FlyBase:FBpp0070117,GB_protein:AAF45536,REFSEQ:NP_569852,FlyMine:FBpp0070117,modMine:FBpp0070117; MD5=0b2b0eb7e4a53b7bc0514af4a08964da; length=108; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • FBpp0310165 type=protein; loc=X:join(647448..647525,647610..647637,647703..647923); ID=FBpp0310165; name=Roc1a-PD; parent=FBgn0025638,FBtr0343564; dbxref=GB_protein:AHN59225,REFSEQ:NP_001284754,FlyBase:FBpp0310165,FlyBase_Annotation_IDs:CG16982-PD; MD5=0b2b0eb7e4a53b7bc0514af4a08964da; length=108; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=X:join(647448..647525,647610..647637,647703..647923); ID=FBpp0070117; name=Roc1a-PA; parent=FBgn0025638,FBtr0070122; dbxref=FlyBase_Annotation_IDs:CG16982-PA,FlyBase:FBpp0070117,GB_protein:AAF45536,REFSEQ:NP_569852,UniProt/Swiss-Prot:Q9W5E1,FlyMine:FBpp0070117,modMine:FBpp0070117; MD5=0b2b0eb7e4a53b7bc0514af4a08964da; length=108; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
  • type=protein; loc=X:join(647448..647525,647610..647637,647703..647923); ID=FBpp0310165; name=Roc1a-PD; parent=FBgn0025638,FBtr0343564; dbxref=GB_protein:AHN59225,REFSEQ:NP_001284754,FlyBase:FBpp0310165,FlyBase_Annotation_IDs:CG16982-PD,UniProt/Swiss-Prot:Q9W5E1; MD5=0b2b0eb7e4a53b7bc0514af4a08964da; length=108; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 108 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    cytoplasm [NAS]
    SCF ubiquitin ligase complex [NAS]
    Biological Process: cell proliferation [IMP]
    proteolysis [IMP][TAS]
    smoothened signaling pathway [IMP]
    protein ubiquitination during ubiquitin-dependent protein catabolic process [NAS]
    protein ubiquitination [IDA]
    Molecular Function: ubiquitin-protein ligase activity [IDA][ISS]
    zinc ion binding [IEA]
    protein binding [IEA][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEVDEDGYEV PSSSSKGDKK RFEVKKWNAV ALWAWDIVVD NCAICRNHIM DLCIECQANQ  60
   61 ASATSEECTV AWGVCNHAFH FHCISRWLKT RQVCPLDNRE WDFQKYGH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..108] PSI-BLAST 24.09691 Crystal Structure of The Cand1-Cul1-Roc1 Complex

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  10.2497392096259 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  10.0460587929138 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  8.99384576623969 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  7.6988425139962 bayes_pls_golite062009
  • NEDD8 ligase activity
    		•  5.61847630780351 bayes_pls_golite062009
  • ligase activity
    		•  3.92677358871643 bayes_pls_golite062009
  • binding
    		•  2.78710909602478 bayes_pls_golite062009
  • protein binding
    		•  1.5975811408548 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  1.2126425713931 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  1.03469202541773 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.943706743211193 bayes_pls_golite062009
  • transcription factor binding
    		•  0.90065892745057 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.708499177773075 bayes_pls_golite062009
  • hydrolase activity
    		•  0.52386813728704 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  0.50197530717959 bayes_pls_golite062009
  • SUMO polymer binding
    		•  0.417597867824941 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.393708074680332 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.392372133643049 bayes_pls_golite062009
  • DNA binding
    		•  0.365874679056682 bayes_pls_golite062009
  • ubiquitin thiolesterase activity
    		•  0.265769062717221 bayes_pls_golite062009
  • catalytic activity
    		•  0.14112008370434 bayes_pls_golite062009
  • enzyme binding
    		•  0.104373352314595 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle