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Protein Overview: spn-A-PA

General Information:
Name(s) found: spn-A-PA / FBpp0084955 [FlyBase]
Description(s) found:
Found 30 descriptions.
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  • The gene spindle A is referred to in FlyBase by the symbol Dmel\spn-A (CG7948, FBgn0003479). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:25880418..25881767. It has the cytological map location 99D3. Based on sequence similarity, it is predicted to have molecular function</span>: recombinase activity. There is experimental evidence that it is involved in the biological process</span>: germarium-derived oocyte fate determination; female meiosis; double-strand break repair via synthesis-dependent strand annealing; polarity specification of dorsal/ventral axis; intracellular mRNA localization; cell cycle checkpoint; oogenesis; polarity specification of anterior/posterior axis; karyosome formation. 28 alleles are reported. The phenotypes of these alleles are annotated with: germline cyst; chorion; egg; oocyte; presumptive oocyte; karyosome; egg chamber; dorsal appendage; nurse cell; synaptonemal complex. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 336 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    Biological Process: DNA repair [ISS]
    intracellular mRNA localization [IMP][TAS]
    female meiosis [IMP]
    germarium-derived oocyte fate determination [IGI]
    DNA recombination [ISS]
    polarity specification of dorsal/ventral axis [IMP]
    oocyte differentiation [NAS]
    double-strand break repair via synthesis-dependent strand annealing [IMP]
    DNA metabolic process [IEA]
    polarity specification of anterior/posterior axis [IMP]
    cell cycle checkpoint [IMP]
    oogenesis [IMP][TAS]
    karyosome formation [IMP]
    Molecular Function: ATP binding [IEA]
    DNA-dependent ATPase activity [IEA][NAS]
    protein binding [IEA]
    recombinase activity [ISS]
    damaged DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEKLTNVQAQ QEEEEEEGPL SVTKLIGGSI TAKDIKLLQQ ASLHTVESVA NATKKQLMAI  60
   61 PGLGGGKVEQ IITEANKLVP LGFLSARTFY QMRADVVQLS TGSKELDKLL GGGIETGSIT 120
  121 EIFGEFRCGK TQLCHTLAVT CQLPISQKGG EGKCMYIDTE NTFRPERLAA IAQRYKLNES 180
  181 EVLDNVAFTR AHNSDQQTKL IQMAAGMLFE SRYALLIVDS AMALYRSDYI GRGELAARQN 240
  241 HLGLFLRMLQ RLADEFGVAV VITNQVTASL DGAPGMFDAK KPIGGHIMAH SSTTRLYLRK 300
  301 GKGETRICKI YDSPCLPESE AMFAILPDGI GDARES

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..336] PSI-BLAST 73.045757 A Crystal Structure of the Rad51 Filament

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA clamp loader activity
    		•  3.22518920754305 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  3.19273435123154 bayes_pls_golite062009
  • transporter activity
    		•  3.13325129560423 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.92327745911863 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  2.72462789867829 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • bubble DNA binding
    		•  2.62179925837003 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.36915495988847 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.29436982996465 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  2.29320453203372 bayes_pls_golite062009
  • DNA helicase activity
    		•  2.2817164193758 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.27303683020046 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.27190707957159 bayes_pls_golite062009
  • DNA polymerase activity
    		•  2.24959734952703 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.21184938313192 bayes_pls_golite062009
  • hydrolase activity
    		•  2.18454736627863 bayes_pls_golite062009
  • double-strand/single-strand DNA junction binding
    		•  2.02697209084624 bayes_pls_golite062009
  • telomeric DNA binding
    		•  1.98044285764127 bayes_pls_golite062009
  • DNA binding
    		•  1.94055378599526 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  1.88455339138556 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.83584389083042 bayes_pls_golite062009
  • ATPase activity
    		•  1.76238574289941 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.72529279238106 bayes_pls_golite062009
  • helicase activity
    		•  1.70242731830224 bayes_pls_golite062009
  • microtubule motor activity
    		•  1.6537049553461 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  1.57826779898847 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.37694050923424 bayes_pls_golite062009
  • motor activity
    		•  1.34881124154297 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.2539059700735 bayes_pls_golite062009
  • protein transporter activity
    		•  1.25342367751911 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.117585097627 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.03207287083227 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • single-stranded telomeric DNA binding
    		•  0.847538346941812 bayes_pls_golite062009
  • double-stranded telomeric DNA binding
    		•  0.75018916645383 bayes_pls_golite062009
  • transcription activator activity
    		•  0.739301862805678 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.725611289205392 bayes_pls_golite062009
  • nucleotide binding
    		•  0.717697610309727 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.713814218071151 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.713752628021599 bayes_pls_golite062009
  • transcription factor activity
    		•  0.697256579145077 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.568457189190858 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.560681051761979 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.500462538667228 bayes_pls_golite062009
  • recombinase activity
    		•  0.45851158693664 bayes_pls_golite062009
  • GTPase activity
    		•  0.437665353870877 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.367559137329714 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.34746349346164 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  0.328186246219424 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  0.328186246219424 bayes_pls_golite062009
  • centromeric DNA binding
    		•  0.322818640526369 bayes_pls_golite062009
  • mismatched DNA binding
    		•  0.31144582840038 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.30832907234141 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.296406132096546 bayes_pls_golite062009
  • GTP binding
    		•  0.295705904888768 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.29532978396745 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.29028316917561 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.248710418805919 bayes_pls_golite062009
  • ATP binding
    		•  0.19169045543599 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.165732470448462 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.162060759063149 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.114463153989353 bayes_pls_golite062009
  • microfilament motor activity
    		•  0.10236059675512 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.089234257580272 bayes_pls_golite062009
  • 3'-5' DNA helicase activity
    		•  0.0769112340058804 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0704128024645565 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  0.0378638259240902 bayes_pls_golite062009
  • actin binding
    		•  0.00482938540552702 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle