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Protein Overview: Apc-PA, FBpp0307743

General Information:
Name(s) found: FBpp0307743 [FlyBase]
Apc-PA / FBpp0084720 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • type=protein; loc=3R:complement(24658957..24662208,24662269..24662407,24662621..24666483); ID=FBpp0307743; name=Apc-PB; parent=FBgn0015589,FBtr0336767; dbxref=FlyBase:FBpp0307743,FlyBase_Annotation_IDs:CG1451-PB,REFSEQ:NP_001263046,GB_protein:AGB96426; MD5=2047cf85a167b358eb71ec5c195b443a; length=2417; release=r5.56; species=Dmel; [FlyBase]
  • The gene APC-like is referred to in FlyBase by the symbol Dmel\Apc (CG1451, FBgn0015589). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:24658022..24670372. It has the cytological map location 98E5-98E6. There is experimental evidence that it has the molecular function</span>: beta-catenin binding. There is experimental evidence for 12 unique biological process</span> terms, many of which group under: anatomical structure development; regulation of Wnt receptor signaling pathway; organ development; regulation of biological process; central nervous system development; larval chitin-based cuticle development; cell adhesion; regulation of developmental process; regulation of signal transduction; negative regulation of cell death; cell proliferation; cell-cell adhesion; cellular component movement; reproductive process in a multicellular organism; embryonic development via the syncytial blastoderm; instar larval development. 10 alleles are reported. The phenotypes of these alleles are annotated with 11 unique terms, many of which group under: external compound sense organ; peripheral nervous system; nervous system; compound cell cluster organ; organ system; sensillum; hub cell; germinal proliferation center hub; adult; gonad. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2417 amino acids

    Gene Ontology:
    Cellular Component: apical part of cell [IDA]
    cytoplasm [IDA]
    microtubule associated complex [ISS]
    axon [IDA]
    Biological Process: cell-cell adhesion [IGI]
    chitin-based larval cuticle pattern formation [IGI]
    head involution [IGI]
    axon guidance [IGI]
    brain development [IGI]
    imaginal disc pattern formation [IGI]
    microtubule-based process [ISS]
    neuroblast proliferation [IGI]
    medulla oblongata development [IGI]
    negative regulation of compound eye retinal cell programmed cell death [IMP]
    negative regulation of Wnt receptor signaling pathway [IGI]
    regulation of Wnt receptor signaling pathway [IGI]
    oocyte localization during germarium-derived egg chamber formation [IGI]
    Molecular Function: beta-catenin binding [IDA]
    microtubule binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLEPTLTPDL EEGIAELSLE DVDVDSVPER KPHFLDYDAV PPPDYEEGFG ASSGEQLKMD  60
   61 KKYERDGEVS DYELAASGYT KKEFTQDDNT LHFTQSAVGL GSGAVGKKPA AKHFLDENPI 120
  121 PPDYMLAQEL REMREHRSLD RNFERQSAQQ QQLDELPPRN GGGSPASAGR PSRSKEPSYT 180
  181 LSRFLDGDAP APAPRLPKGA AWTTSFDERY TSSAVEATLG SKVECVYSLL SMLGSNDPLE 240
  241 MAKKFLELSG NAQSCATLRR SGCMPLLVQM MHAPDNDQEV RKCAGQALHN VVHSHPDEKA 300
  301 GRREAKVLRL LDQIVDYCSF LKTLLQSGGE AIADDSDRHP LAAISSLMKV SFDEEHRHAM 360
  361 CELGALHAIP NLVHLDHAVH GPKPEDQCCN SLRRYALMAL TNLTFGDENN KALLCGQKQF 420
  421 MEALVAQLDS APDDLLQVTA SVLRNLSWRA DSNMKAVLNE IGTVTALALA AMRNRSENTL 480
  481 KAILSALWNL SAHCSTNKAE FCAVDGALAF LVGMLSYEGP SKTLKIIENA GGILRNVSSH 540
  541 IAVCEPYRQI LRQHNCLAIL LQQLKSESLT VVSNSCGTLW NLSARSAEDQ KFLWDNGAVP 600
  601 MLRSLIHSKH AMISEGSSSA LKNLLNFRPA VQNHHQLDPI ARSMGLKALP TLEARKAKAL 660
  661 QQELGERHTA ETCDNLDTGG KLDKERASSS SRRHPAPRLT RSAMLTKSES RDSVYSAKSD 720
  721 CAYDHLIRSA SASDAHRKVK PKITDFDLEM EQDTEATEEQ PIDYSVKYSE NATKTSTYQE 780
  781 TDLDQPTDFS LRYAENQIES DLDISGPAGG QKSTITPPAE TVPEKSEGQE ILLILDDSVK 840
  841 CYQTEDTPYV ISNAASVTDL RVAAKADAEA EVKPEVREVT SKEGAPKKLP KLSQCGSGSY 900
  901 TPEKPINYCE EGTPGYFSRY DSLSSLDESG KANQAIVGTD ADIKPKLEKQ EEQESQPAEQ 960
  961 VLTKPPTQAN SALETPLMFS RRSSMDSLVH DPDVDVANCD DKSSVVSDFS RLASGVISPS1020
 1021 EIPDSPTQSM PQSPRRNSVA GSGQNVDSPP VVIPASLQPL RSVFEDDLSS FNVEHTPAQF1080
 1081 STATSLSNLS IVDDEKAPAS VAEEDNEDEL LLANCINMGM QRKPTEAVKS TVVNSEVDVA1140
 1141 EETIRSYCTE DTPALLSKVP SNTNLSVISM SSTDPKDATA GQAQMYAHQL SDDVSSNASD1200
 1201 CGGASGHLLQ QCIRDGMKKP LGEATSDPIA MLRRGGNELP GYLPSADEMN KFLVEDSPCN1260
 1261 FSVVSGLSNL TVGSSLVGPA VQLKETEPSS ADQNPEMKAK PGKQEQVRRP PHWQDDSLSS1320
 1321 LSIDSEDDTN LLSQAIAAGC NRPKSNLGFS SNGKRSSSLS SSQPIAINAA TSASSLNSAM1380
 1381 TVRKSQQQES YSSVDSSDSN DNQSKSLFEL CILKGMYKTK EPGARAQQMQ EQPIVGSSSV1440
 1441 QSNPSLKQFD SLPVQLPSSG QVKRQRHHHH HHHHRERERE RKDEKLLQEC INTGISKKIN1500
 1501 AVPKNVLATS AAALEPCHPM AATTSASALS TAAPDVEQKA HATSNPQQQS STHPSSHILP1560
 1561 NPIDAIATVT DTVRSPAAPN QGNGNASQNG LETATGSKDL DSEDRSSDES NQSFIMETMV1620
 1621 RLDSALNETC ISGASEKHKD PDLMLKSVER LTMEFVTSAE QLRSSSHNHS SSNSHKNNSS1680
 1681 NNTWNESTCP NDVSFPSVSQ TAPVLASLSL DEDATEARSL HELIEITPTN EQQPESLEGE1740
 1741 TDTLVNGHAD SYSGSSGGLN FQLGGQVQNA GVRLEPQRLL FNGTSASIMT NSTMIAFEAR1800
 1801 ALAENLLQPA ATDDDTTEMT FSLNSLDLDN IRPPSGMESL NSCYQDHSQP SSLRQAMPSK1860
 1861 SPRFARKMFP ANLVARRALG HLAGSAESVN SSCNLLDNIK PPSLMDELLD SMISVDSIQS1920
 1921 EVADGEQDCS MATTISVSNY ETAACDDQTM TVLQSCFDED EDATMNDYSS AESTPKHGST1980
 1981 PSPNRRSLTP KDKRRLTKDR FKTYTIATSC EMEAPEANET LQIEIVEAAV PVATPSPRAN2040
 2041 GRRRGSAERY KTQLIECPLA LIQPQPDDCP SEQLSSIRAM MQQFTFITDI NIGHSQETCE2100
 2101 STDHPEDAGE SPECDQNSET ESCDGQEPDQ LPPPPSIVDL RTSVVKPTTL EPATAVKLVR2160
 2161 GRKKPAYVSP YSMQSQRNSN NAAPSKKKTL SPTIAKRSLV PGGSGVRLPA KKKPTPPPEP2220
 2221 APARLERQGT FVKDEPTNSN VQVPVVETKP AQTSPTHRAS KLPTKKGTAS GGSPSKAGSP2280
 2281 KRIPLAPARR MTPQRANTSL RLAAGKSHAA SRVVSGRVSS TTPPSRSNSN LNGSSAAAAA2340
 2341 AAKINHAQSR IANIWKRVDE AKTKQSSSNL RTQKTKSSNM LNANGTKPTL LRSSTFDNTP2400
 2401 STAGGVKSKL PVVGARK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..97] deduced N/A No confident structure predictions are available.
    2 View Details [98..160] PSI-BLAST 14.69897 Tumor suppressor gene product Apc
    3 View Details [161..630] PSI-BLAST 126.0 beta-Catenin
    4 View Details [631..684] deduced N/A No confident structure predictions are available.
    5 View Details [685..825] deduced N/A No confident structure predictions are available.
    6 View Details [826..955] deduced N/A No confident structure predictions are available.
    7 View Details [956..1083] FFAS03 2.45 Beta-catenin in complex with a phosphorylated APC 20aa repeat fragment
    8 View Details [1084..1281] deduced N/A No confident structure predictions are available.
    9 View Details [1282..1396] MSA 1.132988 View MSA. No confident structure predictions are available.
    10 View Details [1397..1589] deduced N/A No confident structure predictions are available.
    11 View Details [1590..1794] deduced N/A No confident structure predictions are available.
    12 View Details [1795..2030] deduced N/A No confident structure predictions are available.
    13 View Details [2031..2114] deduced N/A No confident structure predictions are available.
    14 View Details [2115..2236] MSA 1.128988 View MSA. No confident structure predictions are available.
    15 View Details [2237..2417] MSA 1.117985 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  3.0667965351474 bayes_pls_golite062009
  • protein binding
    		•  2.78733902345842 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.74745843355294 bayes_pls_golite062009
  • protein transporter activity
    		•  2.71371809786708 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.61566088685247 bayes_pls_golite062009
  • transporter activity
    		•  2.44584964322784 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.23613166876856 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.16673352512615 bayes_pls_golite062009
  • DNA binding
    		•  1.95242774903625 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  1.83254788740042 bayes_pls_golite062009
  • actin binding
    		•  1.76244772281676 bayes_pls_golite062009
  • RPTP-like protein binding
    		•  1.38347756516661 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.24772365783803 bayes_pls_golite062009
  • transcription factor activity
    		•  1.20660383756339 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.06768761940869 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.05960420053443 bayes_pls_golite062009
  • signal transducer activity
    		•  1.05960420053443 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  0.77052454980864 bayes_pls_golite062009
  • structural molecule activity
    		•  0.440301695287117 bayes_pls_golite062009
  • hydrolase activity
    		•  0.42501390959416 bayes_pls_golite062009
  • RNA binding
    		•  0.40024158562931 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.222115326695668 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.221267538887804 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.196648209113174 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.187792942463938 bayes_pls_golite062009
  • peptide binding
    		•  0.17066729499393 bayes_pls_golite062009
  • transcription activator activity
    		•  0.160275383613705 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.149265988041485 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.145736947807635 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.145426459009789 bayes_pls_golite062009
  • cadherin binding
    		•  0.1400783779596 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0810031465868464 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0443466434497628 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0355990844321387 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0330014214401512 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0221966060394205 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0149637869665291 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.
    11 No functions predicted.
    12 No functions predicted.
    13 No functions predicted.
    14 No functions predicted.
    15 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle