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View Structure Prediction Details

Protein: Apc-PA, FBpp0307743
Organism: Drosophila melanogaster
Length: 2417 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Apc-PA, FBpp0307743.

Description E-value Query
Range		 Subject
Range
gi|7511803, gi|1... - pir||T13825 adenomatous polyposis coli protein - fruit fly (Drosophila melanogaster), gi|1800229|gb...
 1034.0 [0..1] [2417..1]

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Predicted Domain #1
Region A:
Residues: [1-97] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLEPTLTPDL EEGIAELSLE DVDVDSVPER KPHFLDYDAV PPPDYEEGFG ASSGEQLKMD  60
   61 KKYERDGEVS DYELAASGYT KKEFTQDDNT LHFTQSA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [98-160] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGLGSGAVGK KPAAKHFLDE NPIPPDYMLA QELREMREHR SLDRNFERQS AQQQQLDELP  60
   61 PRN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.69897
Match: 1m5iA
Description: Tumor suppressor gene product Apc
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [161-630] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGGSPASAGR PSRSKEPSYT LSRFLDGDAP APAPRLPKGA AWTTSFDERY TSSAVEATLG  60
   61 SKVECVYSLL SMLGSNDPLE MAKKFLELSG NAQSCATLRR SGCMPLLVQM MHAPDNDQEV 120
  121 RKCAGQALHN VVHSHPDEKA GRREAKVLRL LDQIVDYCSF LKTLLQSGGE AIADDSDRHP 180
  181 LAAISSLMKV SFDEEHRHAM CELGALHAIP NLVHLDHAVH GPKPEDQCCN SLRRYALMAL 240
  241 TNLTFGDENN KALLCGQKQF MEALVAQLDS APDDLLQVTA SVLRNLSWRA DSNMKAVLNE 300
  301 IGTVTALALA AMRNRSENTL KAILSALWNL SAHCSTNKAE FCAVDGALAF LVGMLSYEGP 360
  361 SKTLKIIENA GGILRNVSSH IAVCEPYRQI LRQHNCLAIL LQQLKSESLT VVSNSCGTLW 420
  421 NLSARSAEDQ KFLWDNGAVP MLRSLIHSKH AMISEGSSSA LKNLLNFRPA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 126.0
Match: 1jpwA
Description: beta-Catenin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.0667965351474 bayes_pls_golite062009
protein binding 2.78733902345842 bayes_pls_golite062009
nucleic acid binding 2.74745843355294 bayes_pls_golite062009
protein transporter activity 2.71371809786708 bayes_pls_golite062009
cytoskeletal protein binding 2.61566088685247 bayes_pls_golite062009
transporter activity 2.44584964322784 bayes_pls_golite062009
substrate-specific transporter activity 2.23613166876856 bayes_pls_golite062009
transcription regulator activity 2.16673352512615 bayes_pls_golite062009
DNA binding 1.95242774903625 bayes_pls_golite062009
cell adhesion molecule binding 1.83254788740042 bayes_pls_golite062009
actin binding 1.76244772281676 bayes_pls_golite062009
RPTP-like protein binding 1.38347756516661 bayes_pls_golite062009
transmembrane transporter activity 1.24772365783803 bayes_pls_golite062009
transcription factor activity 1.20660383756339 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.06768761940869 bayes_pls_golite062009
molecular transducer activity 1.05960420053443 bayes_pls_golite062009
signal transducer activity 1.05960420053443 bayes_pls_golite062009
protein transmembrane transporter activity 0.77052454980864 bayes_pls_golite062009
structural molecule activity 0.440301695287117 bayes_pls_golite062009
hydrolase activity 0.42501390959416 bayes_pls_golite062009
RNA binding 0.40024158562931 bayes_pls_golite062009
ion transmembrane transporter activity 0.222115326695668 bayes_pls_golite062009
active transmembrane transporter activity 0.221267538887804 bayes_pls_golite062009
primary active transmembrane transporter activity 0.196648209113174 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.187792942463938 bayes_pls_golite062009
peptide binding 0.17066729499393 bayes_pls_golite062009
transcription activator activity 0.160275383613705 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.149265988041485 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.145736947807635 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.145426459009789 bayes_pls_golite062009
cadherin binding 0.1400783779596 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0810031465868464 bayes_pls_golite062009
pyrophosphatase activity 0.0443466434497628 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0355990844321387 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0330014214401512 bayes_pls_golite062009
transcription factor binding 0.0221966060394205 bayes_pls_golite062009
cation transmembrane transporter activity 0.0149637869665291 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [631-684] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VQNHHQLDPI ARSMGLKALP TLEARKAKAL QQELGERHTA ETCDNLDTGG KLDK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [685-825] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERASSSSRRH PAPRLTRSAM LTKSESRDSV YSAKSDCAYD HLIRSASASD AHRKVKPKIT  60
   61 DFDLEMEQDT EATEEQPIDY SVKYSENATK TSTYQETDLD QPTDFSLRYA ENQIESDLDI 120
  121 SGPAGGQKST ITPPAETVPE K

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [826-955] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEGQEILLIL DDSVKCYQTE DTPYVISNAA SVTDLRVAAK ADAEAEVKPE VREVTSKEGA  60
   61 PKKLPKLSQC GSGSYTPEKP INYCEEGTPG YFSRYDSLSS LDESGKANQA IVGTDADIKP 120
  121 KLEKQEEQES

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [956-1083] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPAEQVLTKP PTQANSALET PLMFSRRSSM DSLVHDPDVD VANCDDKSSV VSDFSRLASG  60
   61 VISPSEIPDS PTQSMPQSPR RNSVAGSGQN VDSPPVVIPA SLQPLRSVFE DDLSSFNVEH 120
  121 TPAQFSTA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.45
Match: 1th1C
Description: Beta-catenin in complex with a phosphorylated APC 20aa repeat fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [1084-1281] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSLSNLSIVD DEKAPASVAE EDNEDELLLA NCINMGMQRK PTEAVKSTVV NSEVDVAEET  60
   61 IRSYCTEDTP ALLSKVPSNT NLSVISMSST DPKDATAGQA QMYAHQLSDD VSSNASDCGG 120
  121 ASGHLLQQCI RDGMKKPLGE ATSDPIAMLR RGGNELPGYL PSADEMNKFL VEDSPCNFSV 180
  181 VSGLSNLTVG SSLVGPAV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1282-1396] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLKETEPSSA DQNPEMKAKP GKQEQVRRPP HWQDDSLSSL SIDSEDDTNL LSQAIAAGCN  60
   61 RPKSNLGFSS NGKRSSSLSS SQPIAINAAT SASSLNSAMT VRKSQQQESY SSVDS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [1397-1589] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDSNDNQSKS LFELCILKGM YKTKEPGARA QQMQEQPIVG SSSVQSNPSL KQFDSLPVQL  60
   61 PSSGQVKRQR HHHHHHHHRE RERERKDEKL LQECINTGIS KKINAVPKNV LATSAAALEP 120
  121 CHPMAATTSA SALSTAAPDV EQKAHATSNP QQQSSTHPSS HILPNPIDAI ATVTDTVRSP 180
  181 AAPNQGNGNA SQN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #11
Region A:
Residues: [1590-1794] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLETATGSKD LDSEDRSSDE SNQSFIMETM VRLDSALNET CISGASEKHK DPDLMLKSVE  60
   61 RLTMEFVTSA EQLRSSSHNH SSSNSHKNNS SNNTWNESTC PNDVSFPSVS QTAPVLASLS 120
  121 LDEDATEARS LHELIEITPT NEQQPESLEG ETDTLVNGHA DSYSGSSGGL NFQLGGQVQN 180
  181 AGVRLEPQRL LFNGTSASIM TNSTM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #12
Region A:
Residues: [1795-2030] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IAFEARALAE NLLQPAATDD DTTEMTFSLN SLDLDNIRPP SGMESLNSCY QDHSQPSSLR  60
   61 QAMPSKSPRF ARKMFPANLV ARRALGHLAG SAESVNSSCN LLDNIKPPSL MDELLDSMIS 120
  121 VDSIQSEVAD GEQDCSMATT ISVSNYETAA CDDQTMTVLQ SCFDEDEDAT MNDYSSAEST 180
  181 PKHGSTPSPN RRSLTPKDKR RLTKDRFKTY TIATSCEMEA PEANETLQIE IVEAAV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #13
Region A:
Residues: [2031-2114] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVATPSPRAN GRRRGSAERY KTQLIECPLA LIQPQPDDCP SEQLSSIRAM MQQFTFITDI  60
   61 NIGHSQETCE STDHPEDAGE SPEC

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #14
Region A:
Residues: [2115-2236] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DQNSETESCD GQEPDQLPPP PSIVDLRTSV VKPTTLEPAT AVKLVRGRKK PAYVSPYSMQ  60
   61 SQRNSNNAAP SKKKTLSPTI AKRSLVPGGS GVRLPAKKKP TPPPEPAPAR LERQGTFVKD 120
  121 EP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #15
Region A:
Residues: [2237-2417] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TNSNVQVPVV ETKPAQTSPT HRASKLPTKK GTASGGSPSK AGSPKRIPLA PARRMTPQRA  60
   61 NTSLRLAAGK SHAASRVVSG RVSSTTPPSR SNSNLNGSSA AAAAAAKINH AQSRIANIWK 120
  121 RVDEAKTKQS SSNLRTQKTK SSNMLNANGT KPTLLRSSTF DNTPSTAGGV KSKLPVVGAR 180
  181 K

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle