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Protein Overview: tst-PA, FBpp0306916

General Information:
Name(s) found: FBpp0306916 [FlyBase]
tst-PA / FBpp0083853 [FlyBase]
Description(s) found:
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  • gi|23172083|gb|AAF56187.2| twister [Drosophila melanogaster] [NCBI NR]
  • gi|17933658|ref|NP_524465.1| twister [Drosophila melanogaster] [NCBI NR]
  • gi|16769288|gb|AAL28863.1| LD23303p [Drosophila melanogaster] [NCBI NR]
  • type=protein; loc=3R:complement(19594762..19594965,19595031..19596098,19596163..19598484); ID=FBpp0306916; name=tst-PB; parent=FBgn0039117,FBtr0334895; dbxref=FlyBase:FBpp0306916,FlyBase_Annotation_IDs:CG10210-PB,REFSEQ:NP_001262884,GB_protein:AGB96264; MD5=527bfcf7ead479e6391c298be59d4e64; length=1197; release=r5.56; species=Dmel; [FlyBase]
  • The gene twister is referred to in FlyBase by the symbol Dmel\tst (CG10210, FBgn0039117). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:19594121..19598529. It has the cytological map location 95B1. Based on sequence similarity, it is predicted to have molecular function</span>: helicase activity. There is experimental evidence that it is involved in the biological process</span>: regulation of alternative nuclear mRNA splicing, via spliceosome. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG10210-PA translation from_gene[CG10210 tst FBgn0039117] seq_release:3 mol_weight=135770 cds_boundaries:(3R:19,585,422..19,589,141[-]) aa_length:1197 transcript_info:[CG10210-RA seq_release:3] gene_info:[gene symbol:tst FBgn0039117 gene_boundaries:(3 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VCH8) CG10210 protein (LD23303p) [DrosMelano7227.FASTAC.txt]
  • CG10210-PA [Drosophila melanogaster]gi|16769288|gb|AAL28863.1| LD23303p [Drosophila melanogaster]gi|17933658|ref|NP_524465.1| CG10210-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:complement(19594762..19594965,19595031..19596098,19596163..19598484); ID=FBpp0083853; name=tst-PA; parent=FBgn0039117,FBtr0084462; dbxref=FlyBase:FBpp0083853,FlyBase_Annotation_IDs:CG10210-PA,GB_protein:AAF56187.2,REFSEQ:NP_524465,GB_ [fly-100309-contam.fasta]
  • LD23303p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • twister CG10210-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG10210-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:complement(19594762..19594965,19595031..19596098,19596163..19598484); ID=FBpp0083853; name=tst-PA; parent=FBgn0039117,FBtr0084462; dbxref=FlyBase:FBpp0083853,FlyBase_Annotation_IDs:CG10210-PA,GB_protein:AAF56187.2,REFSEQ:NP_524465,GB_protein:AAF56187; MD5=527bfcf7ead479e6391c298be59d4e64; length=1197; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(19594762..19594965,19595031..19596098,19596163..19598484); ID=FBpp0083853; name=tst-PA; parent=FBgn0039117,FBtr0084462; dbxref=FlyBase:FBpp0083853,FlyBase_Annotation_IDs:CG10210-PA,GB_protein:AAF56187.2,REFSEQ:NP_524465,GB_protein:AAF56187; MD5=527bfcf7ead479e6391c298be59d4e64; length=1197; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • LD23303p OS=Drosophila melanogaster GN=tst PE=2 SV=2 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:complement(19594762..19594965,19595031..19596098,19596163..19598484); ID=FBpp0083853; name=tst-PA; parent=FBgn0039117,FBtr0084462; dbxref=FlyBase:FBpp0083853,FlyBase_Annotation_IDs:CG10210-PA,GB_protein:AAF56187.2,REFSEQ:NP_524465,GB_protein:AAF56187,FlyMine:FBpp0083853,modMine:FBpp0083853; MD5=527bfcf7ead479e6391c298be59d4e64; length=1197; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:complement(join(23770441..23772762,23769309..23770376,23769040..23769243)); ID=FBpp0083853; name=tst-PA; parent=FBgn0039117,FBtr0084462; dbxref=FlyBase:FBpp0083853,FlyBase_Annotation_IDs:CG10210-PA,GB_protein:AAF56187.2,REFSEQ:NP_524465,GB_protein:AAF56187,FlyMine:FBpp0083853,modMine:FBpp0083853; MD5=527bfcf7ead479e6391c298be59d4e64; length=1197; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:complement(join(23770441..23772762,23769309..23770376,23769040..23769243)); ID=FBpp0306916; name=tst-PB; parent=FBgn0039117,FBtr0334895; dbxref=FlyBase:FBpp0306916,FlyBase_Annotation_IDs:CG10210-PB,REFSEQ:NP_001262884,GB_protein:AGB96264; MD5=527bfcf7ead479e6391c298be59d4e64; length=1197; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:complement(join(23770441..23772762,23769309..23770376,23769040..23769243)); ID=FBpp0083853; name=tst-PA; parent=FBgn0039117,FBtr0084462; dbxref=FlyBase:FBpp0083853,FlyBase_Annotation_IDs:CG10210-PA,GB_protein:AAF56187.2,REFSEQ:NP_524465,GB_protein:AAF56187,FlyMine:FBpp0083853,modMine:FBpp0083853; MD5=527bfcf7ead479e6391c298be59d4e64; length=1197; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • type=protein; loc=3R:complement(join(23770441..23772762,23769309..23770376,23769040..23769243)); ID=FBpp0306916; name=tst-PB; parent=FBgn0039117,FBtr0334895; dbxref=FlyBase:FBpp0306916,FlyBase_Annotation_IDs:CG10210-PB,REFSEQ:NP_001262884,GB_protein:AGB96264; MD5=527bfcf7ead479e6391c298be59d4e64; length=1197; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • LD23303p OS=Drosophila melanogaster GN=tst PE=1 SV=2 [DROME.fasta.20160308]
  • FBpp0083853 type=protein; loc=3R:complement(join(23770441..23772762,23769309..23770376,23769040..23769243)); ID=FBpp0083853; name=tst-PA; parent=FBgn0039117,FBtr0084462; dbxref=FlyBase:FBpp0083853,FlyBase_Annotation_IDs:CG10210-PA,GB_protein:AAF56187.2,REFSEQ:NP_524465,GB_protein:AAF56187,FlyMine:FBpp0083853,modMine:FBpp0083853; MD5=527bfcf7ead479e6391c298be59d4e64; length=1197; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • FBpp0306916 type=protein; loc=3R:complement(join(23770441..23772762,23769309..23770376,23769040..23769243)); ID=FBpp0306916; name=tst-PB; parent=FBgn0039117,FBtr0334895; dbxref=FlyBase:FBpp0306916,FlyBase_Annotation_IDs:CG10210-PB,REFSEQ:NP_001262884,GB_protein:AGB96264; MD5=527bfcf7ead479e6391c298be59d4e64; length=1197; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:complement(join(23770441..23772762,23769309..23770376,23769040..23769243)); ID=FBpp0083853; name=tst-PA; parent=FBgn0039117,FBtr0084462; dbxref=FlyBase:FBpp0083853,FlyBase_Annotation_IDs:CG10210-PA,GB_protein:AAF56187.2,REFSEQ:NP_524465,GB_protein:AAF56187,UniProt/TrEMBL:Q9VCH8,FlyMine:FBpp0083853,modMine:FBpp0083853; MD5=527bfcf7ead479e6391c298be59d4e64; length=1197; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
  • type=protein; loc=3R:complement(join(23770441..23772762,23769309..23770376,23769040..23769243)); ID=FBpp0306916; name=tst-PB; parent=FBgn0039117,FBtr0334895; dbxref=FlyBase:FBpp0306916,FlyBase_Annotation_IDs:CG10210-PB,REFSEQ:NP_001262884,GB_protein:AGB96264,UniProt/TrEMBL:Q9VCH8; MD5=527bfcf7ead479e6391c298be59d4e64; length=1197; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 1197 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC]
    Biological Process: regulation of alternative nuclear mRNA splicing, via spliceosome [IMP]
    Molecular Function: nucleic acid binding [IEA]
    ATP binding [IEA]
    ATP-dependent helicase activity [IEA]
    helicase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNEIRGEDNL ERLRNYILRP ELSLHNPLPD VLPRKFDPMR LLHAPRCPGS TKLAPRRDQS  60
   61 GHILEFVELD LEAVGANANN SMSMQREPGL LEDATRGSHS NFPFWPGGFD EQRQQIAALD 120
  121 VSNFQFGDKL LTVPPGFSSG YDFFQSQSVT LPPVVADPSN VDLLENLEQD LDVQEWMKLT 180
  181 RSEETSSTGT PKSPKQSNVQ LPSEEFRDVD DHIMKADLKP VLNISTTTKN FKSDWAEMVD 240
  241 ISQPINNFKE QIPCPAMDFP FELDVFQKQA ILKLEQRQYV FVAAHTSAGK TVVAEYAIAL 300
  301 SKRDLTRTIY TSPIKALSNQ KYRDFRKTFK DVGLITGDLQ IEPTASCLIM TTEILRSMLY 360
  361 CGSDVTRDLE WVIFDEVHYI NNPERGHVWE EVIILLPEHV NIIMLSATVP NTLELADWVG 420
  421 STKKRKVYVI STLKRPVPLT HFLYTGAGGK SRDDIFLLVD AQGKYLQGNY EKAVERKKEM 480
  481 QGKAKGGGGG PRNHLNAKQE QYTWIGLIDF LRRSNMMPVV AFTLSRNRCD SNLAALQSVD 540
  541 LNTEKEKGAV QKFFLQCLAK LKPPDRTIPQ VLVLKDALER GIGVHHSGIL PILKEIVEML 600
  601 FQNGLVKLLF ATETFAMGVN MPARTVVFDS CKKFDGLEMR NLKPGEYIQM AGRAGRRGHD 660
  661 ETGTAIIMCK GSVPPSMELR PMILGLPEKL QSQFILRYAV ILTCLRIESI KVEDIMKFSF 720
  721 KEFNLKLQLP TQQKQLRLAE DKFAMLPTLG EHLQPLVNFY DKAVEYWKEK HRIMKFVVTQ 780
  781 PKIQKELKAG RVIVITQGKH YNKLAILLNT KSVPGKDTIY KVLVLDHQFK AKDSNSLQQG 840
  841 ELYYKILSLT PRNMTFQPVG IGGHTVLDIK AIDIISITKS TLKVDADAII RNWEQRQLER 900
  901 FKDSPPSGSV VKAVTELNQL NESYIDNPDN IKYVNLSKEI IVNADSEVAM LNYVDHLLRK 960
  961 VGEFLPHTNI AGFEQEFAKV YERRMLEIHI EELRFKNSAR NLTLYPDYCN KLKVLRALKY1020
 1021 IDELDEVTLK GKVACEMGQN ELLITELILC NMFNDLEPAE IAALLSGLVF QAKMQDKPVI1080
 1081 PEALKECVAA FEQINDTILA EEQRFQAAIE TDNRLNFGLL EVVYEWARNK PFAEIMKLTT1140
 1141 VQEGIIVRCI QQLNETLRDV KTAAIRIGNP GLQSKMEEAS AAIKRDIVFT ASLYTEL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..241] deduced N/A No confident structure predictions are available.
    2 View Details [242..796] PSI-BLAST 25.09691 No description for 2p6rA was found.
    3 View Details [797..969] deduced N/A No confident structure predictions are available.
    4 View Details [970..1080] MSA 1.321972 View MSA. No confident structure predictions are available.
    5 View Details [1081..1197] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • nucleoside-triphosphatase activity
    		•  2.95079405147356 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.87427509025394 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.85499564954033 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.85178667290149 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • transporter activity
    		•  2.58140740499725 bayes_pls_golite062009
  • hydrolase activity
    		•  2.55157966585974 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.51683451033161 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.39695871109024 bayes_pls_golite062009
  • ATPase activity
    		•  2.39535714892224 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.18396165590908 bayes_pls_golite062009
  • DNA binding
    		•  1.94055378599526 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.83584389083042 bayes_pls_golite062009
    		• 1.75135117904448 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.47858140861683 bayes_pls_golite062009
  • RNA helicase activity
    		•  1.42791449104435 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  1.39335733374328 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  1.36724390116598 bayes_pls_golite062009
  • motor activity
    		•  1.34881124154297 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.29730375126024 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • transcription factor activity
    		•  0.959949409533517 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.906554174337376 bayes_pls_golite062009
  • structural molecule activity
    		•  0.86514677273731 bayes_pls_golite062009
  • RNA binding
    		•  0.715902454627085 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.712344060953362 bayes_pls_golite062009
  • helicase activity
    		•  0.6191010101321 bayes_pls_golite062009
  • GTPase activity
    		•  0.437665353870877 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.434775387083003 bayes_pls_golite062009
  • ligase activity
    		•  0.417681194526243 bayes_pls_golite062009
  • ATP binding
    		•  0.41092997612902 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.385813421701492 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.377870145186619 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.355466224802969 bayes_pls_golite062009
  • microtubule motor activity
    		•  0.32730260506261 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.29664013896754 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.29664013896754 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.296406132096546 bayes_pls_golite062009
  • GTP binding
    		•  0.295705904888768 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.294474570607914 bayes_pls_golite062009
  • translation regulator activity
    		•  0.29096092258568 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.29028316917561 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.282352478532746 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.274994961137851 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.220608508617331 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.219533217661421 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.219157471322311 bayes_pls_golite062009
  • microfilament motor activity
    		•  0.10236059675512 bayes_pls_golite062009
  • protein transporter activity
    		•  0.0397092337273124 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0254369227200564 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle