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Protein Overview: Rpn7-PA

General Information:
Name(s) found: Rpn7-PA / FBpp0083687 [FlyBase]
Description(s) found:
Found 27 descriptions.
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  • The gene Rpn7 is referred to in FlyBase by the symbol Dmel\Rpn7 (CG5378, FBgn0028688). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:18286380..18287772. It has the cytological map location 94A15. There is experimental evidence that it has the molecular function</span>: endopeptidase activity; SUMO binding. There is experimental evidence that it is involved in the biological process</span>: cellular process; proteolysis. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 389 amino acids

    Gene Ontology:
    Cellular Component: proteasome regulatory particle [IDA][ISS][NAS]
    proteasome regulatory particle, lid subcomplex [ISS][NAS]
    Biological Process: proteolysis [IDA][ISS][NAS]
    cellular process [IMP]
    Molecular Function: SUMO binding [IPI]
    endopeptidase activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPAENLEEQG LEKNPNLELA QTKFLLTLAE YKQDAALKAK LLEAIRTENM APWYEHICSE  60
   61 LGWTVDKDLL ARMKENNRVE VEQLDAAIED AEKNLGEMEV REANLKKSEY LCRIGDKAAA 120
  121 ETAFRKTYEK TVSLGHRLDI VFHLIRLGLF YLDHDLITRN IDKAKYLIEE GGDWDRRNRL 180
  181 KVYQGVYSVA VRDFKAAATF FLDTVSTFTS YELMDYPTFV RYTVYVAMIA LPRNELRDKV 240
  241 IKGSEIQEVL HGLPDVKQFL FSLYNCQYEN FYVHLAGVEK QLRLDYLIHP HYRYYVREMR 300
  301 ILGYTQLLES YRSLTLQYMA ESFGVTVEYI DQELARFIAA GRLHAKVDRV GGIVETNRPD 360
  361 NKNWQYQATI KQGDLLLNRI QKLSRVINI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..276] FFAS03 3.07 Vesicular transport protein sec17
    2 View Details [277..389] PSI-BLAST 9.522879 Solution structure of the PCI domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrolase activity
    		•  2.802999698299 bayes_pls_golite062009
  • binding
    		•  2.45002000313605 bayes_pls_golite062009
  • protein binding
    		•  1.41340296563325 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.499034250223658 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.447205684237625 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.437277381081288 bayes_pls_golite062009
  • enzyme binding
    		•  0.335436488591595 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.326419413972955 bayes_pls_golite062009
  • DNA binding
    		•  0.186035324819401 bayes_pls_golite062009
  • signal sequence binding
    		•  0.0263114188894915 bayes_pls_golite062009
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  3.50995556050336 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.38144578566524 bayes_pls_golite062009
  • binding
    		•  3.33026160538031 bayes_pls_golite062009
  • DNA binding
    		•  3.30822066787723 bayes_pls_golite062009
  • transcription factor activity
    		•  2.60537570879007 bayes_pls_golite062009
  • hydrolase activity
    		•  2.30467124306022 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.32971938164691 bayes_pls_golite062009
  • transcription activator activity
    		•  1.08566311616647 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.95491822926452 bayes_pls_golite062009
  • protein binding
    		•  0.653872239015235 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.505349137311395 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.42135864069093 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.136726704233672 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.118016217031359 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle