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Protein Overview: DNApol-alpha180-PA

General Information:
Name(s) found: DNApol-alpha180-PA / FBpp0083514 [FlyBase]
Description(s) found:
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  • gi|45644974|sp|P26019.2|DPOLA_DROME RecName: Full=DNA polymerase alpha catalytic subunit [NCBI NR]
  • gi|24648780|ref|NP_536736.2| DNA polymerase alpha 180kD [Drosophila melanogaster] [NCBI NR]
  • gi|23171902|gb|AAF55908.2| DNA polymerase alpha 180kD [Drosophila melanogaster] [NCBI NR]
  • DNA polymerase alpha catalytic subunit OS=Drosophila melanogaster GN=DNApol-alpha180 PE=1 SV=2 [Swiss-Prot]
  • (P26019) DNA polymerase alpha catalytic subunit (EC 2.7.7.7) [Swiss-Prot]
  • The gene DNA polymerase Ã?&#142;Ã?± 180kD is referred to in FlyBase by the symbol Dmel\DNApol-Ã?&#142;Ã?±180 (CG6349, FBgn0259113). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:17492275..17497472. It has the cytological map location 93F2. There is experimental evidence that it has the molecular function</span>: DNA-directed DNA polymerase activity. There is experimental evidence that it is involved in the biological process</span>: DNA replication. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG6349-PA translation from_gene[CG6349 DNApol-alpha180 FBgn0004493] seq_release:3 mol_weight=169905 cds_boundaries:(3R:17,483,303..17,488,331[-]) aa_length:1488 transcript_info:[CG6349-RA seq_release:3] gene_info:[gene symbol:DNApol-alpha180 FBgn00044 [hmr_yeast5_DM3-1_pombe.fasta]
  • CG6349-PA [Drosophila melanogaster]gi|24648780|ref|NP_536736.2| CG6349-PA [Drosophila melanogaster]gi|45644974|sp|P26019|DPOA_DROME DNA polymerase alpha catalytic subunit [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:complement(17492336..17492532,17492862..17493340,17493401..17495961,17496027..17497045,17497099..17497293,17497352..17497367); ID=FBpp0083514; name=DNApol-alpha180-PA; parent=FBgn0259113,FBtr0084115; dbxref=FlyBase:FBpp0083514,FlyBase [fly-100309-contam.fasta]
  • DNA polymerase alpha catalytic subunit [nr-271106-contam.fasta]
  • DNA polymerase alpha 180kD CG6349-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG6349-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:complement(17492336..17492532,17492862..17493340,17493401..17495961,17496027..17497045,17497099..17497293,17497352..17497367); ID=FBpp0083514; name=DNApol-alpha180-PA; parent=FBgn0259113,FBtr0084115; dbxref=FlyBase:FBpp0083514,FlyBase_Annotation_IDs:CG6349-PA,GB_protein:AAF55908.2,REFSEQ:NP_536736,GB_protein:AAF55908; MD5=3ecfe10f17a69a353ef0e8713ee7ec93; length=1488; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(17492336..17492532,17492862..17493340,17493401..17495961,17496027..17497045,17497099..17497293,17497352..17497367); ID=FBpp0083514; name=DNApol-alpha180-PA; parent=FBgn0259113,FBtr0084115; dbxref=FlyBase:FBpp0083514,FlyBase_Annotation_IDs:CG6349-PA,GB_protein:AAF55908.2,REFSEQ:NP_536736,GB_protein:AAF55908; MD5=3ecfe10f17a69a353ef0e8713ee7ec93; length=1488; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=3R:complement(17492336..17492532,17492862..17493340,17493401..17495961,17496027..17497045,17497099..17497293,17497352..17497367); ID=FBpp0083514; name=DNApol-alpha180-PA; parent=FBgn0259113,FBtr0084115; dbxref=FlyBase:FBpp0083514,FlyBase_Annotation_IDs:CG6349-PA,GB_protein:AAF55908.2,REFSEQ:NP_536736,GB_protein:AAF55908,FlyMine:FBpp0083514,modMine:FBpp0083514; MD5=3ecfe10f17a69a353ef0e8713ee7ec93; length=1488; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:complement(join(21671630..21671645,21671377..21671571,21670305..21671323,21667679..21670239,21667140..21667618,21666614..21666810)); ID=FBpp0083514; name=DNApol-alpha180-PA; parent=FBgn0259113,FBtr0084115; dbxref=FlyBase:FBpp0083514,FlyBase_Annotation_IDs:CG6349-PA,GB_protein:AAF55908.2,REFSEQ:NP_536736,GB_protein:AAF55908,FlyMine:FBpp0083514,modMine:FBpp0083514; MD5=3ecfe10f17a69a353ef0e8713ee7ec93; length=1488; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:complement(join(21671630..21671645,21671377..21671571,21670305..21671323,21667679..21670239,21667140..21667618,21666614..21666810)); ID=FBpp0083514; name=DNApol-alpha180-PA; parent=FBgn0259113,FBtr0084115; dbxref=FlyBase:FBpp0083514,FlyBase_Annotation_IDs:CG6349-PA,GB_protein:AAF55908.2,REFSEQ:NP_536736,GB_protein:AAF55908,FlyMine:FBpp0083514,modMine:FBpp0083514; MD5=3ecfe10f17a69a353ef0e8713ee7ec93; length=1488; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0083514 type=protein; loc=3R:complement(join(21671630..21671645,21671377..21671571,21670305..21671323,21667679..21670239,21667140..21667618,21666614..21666810)); ID=FBpp0083514; name=DNApol-alpha180-PA; parent=FBgn0259113,FBtr0084115; dbxref=FlyBase:FBpp0083514,FlyBase_Annotation_IDs:CG6349-PA,GB_protein:AAF55908.2,REFSEQ:NP_536736,GB_protein:AAF55908,FlyMine:FBpp0083514,modMine:FBpp0083514; MD5=3ecfe10f17a69a353ef0e8713ee7ec93; length=1488; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:complement(join(21671630..21671645,21671377..21671571,21670305..21671323,21667679..21670239,21667140..21667618,21666614..21666810)); ID=FBpp0083514; name=DNApol-alpha180-PA; parent=FBgn0259113,FBtr0084115; dbxref=FlyBase:FBpp0083514,FlyBase_Annotation_IDs:CG6349-PA,GB_protein:AAF55908.2,REFSEQ:NP_536736,GB_protein:AAF55908,UniProt/Swiss-Prot:P26019,FlyMine:FBpp0083514,modMine:FBpp0083514; MD5=3ecfe10f17a69a353ef0e8713ee7ec93; length=1488; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 1488 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    alpha DNA polymerase:primase complex [IDA][ISS][NAS]
    Biological Process: DNA replication [IDA][IEA]
    DNA strand elongation involved in DNA replication [NAS]
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [IEA]
    Molecular Function: nucleotide binding [IEA]
    DNA binding [IEA]
    DNA-directed DNA polymerase activity [IDA][ISS][NAS]
    3'-5'-exodeoxyribonuclease activity [NAS]
    nucleoside binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSESPSEPRA KRQRVDKNGR FAAMERLRQL KGTKNKCKVE DQVDDVYDVV DEREYAKRAQ  60
   61 EKYGDDWIEE DGTGYAEDLR DFFEDEDEYS DGEEDRKDSK KKKGVAPNSK KRPRENEKPV 120
  121 TGKASIKNLF SNAVPKKMDV KTSVKDDDIL ADILGEIKEE PAATSEKAEK VIAPAKISVT 180
  181 SRKFDAAAAK EYMNSFLNNI KVQEQERKKA EASSDNEMLE RILKPKAAVP NTKVAFFSSP 240
  241 TIKKEPMPEK TPAKKATEDP FSDNEMDFSC LDDDENQFDV EKTQQTEKVS QTKTAAEKTS 300
  301 QSKVAEKSAP KKETTGSPKE SESEDISRLL NNWESICQMD DDFEKSVLTT EQDSTISSDQ 360
  361 QLRFWYWEAY EDPVKMPGEV FLFGRTADGK SVCLRVQNIN RVLYLLPRQF LLDPISKEPT 420
  421 KQKVTVADIY KEFDSEVANQ LKLEFFRSRK VTKSFAHHAI GIEVPQSCDY LEVHYDGKKP 480
  481 LPNLSADKKY NSIAHIFGAT TNALERFLLD RKIKGPCWLQ VTGFKVSPTP MSWCNTEVTL 540
  541 TEPKNVELVQ DKGKPAPPPP LTLLSLNVRT SMNPKTSRNE ICMISMLTHN RFHIDRPAPQ 600
  601 PAFNRHMCAL TRPAVVSWPL DLNFEMAKYK STTVHKHDSE RALLSWFLAQ YQKIDADLIV 660
  661 TFDSMDCQLN VITDQIVALK IPQWSRMGRL RLSQSFGKRL LEHFVGRMVC DVKRSAEECI 720
  721 RARSYDLQTL CKQVLKLKES ERMEVNADDL LEMYEKGESI TKLISLTMQD NSYLLRLMCE 780
  781 LNIMPLALQI TNICGNTMTR TLQGGRSERN EFLLLHAFHE KNYIVPDKKP VSKRSGAGDT 840
  841 DATLSGADAT MQTKKKAAYA GGLVLEPMRG LYEKYVLLMD FNSLYPSIIQ EYNICFTTVQ 900
  901 QPVDADELPT LPDSKTEPGI LPLQLKRLVE SRKEVKKLMA APDLSPELQM QYHIRQMALK 960
  961 LTANSMYGCL GFAHSRFFAQ HLAALVTHKG REILTNTQQL VQKMNYDVVY GDTDSLMINT1020
 1021 NITDYDQVYK IGHNIKQSVN KLYKQLELDI DGVFGCLLLL KKKKYAAIKL SKDSKGNLRR1080
 1081 EQEHKGLDIV RRDWSQLAVM VGKAVLDEVL SEKPLEEKLD AVHAQLEKIK TQIAEGVVPL1140
 1141 PLFVITKQLT RTPQEYANSA SLPHVQVALR MNRERNRRYK KGDMVDYVIC LDGTTNAAMQ1200
 1201 RAYHLDELKT SEDKKLQLDT NYYLGHQIHP VVTRMVEVLE GTDASRIAEC LGMDPTKFRQ1260
 1261 NAQRTQRENT EQSEGESLLK TTLQLYRLCE PFRFQCVTCK TEQLMASAYR PGPSNSHIAV1320
 1321 LQQCAKSECQ TAPIQYLASV RNQLQLSMRQ YVQRFYKNWL VCDHPDCNFN TRTHSLRKKS1380
 1381 HRPLCQKCRS GSLLRQYTER DLYNQLCYLR FMFDLGKQTL QQKPTLTPEL EQAYQLLYET1440
 1441 VDQQLQSSSY VIISLSKLFA RSLAQMSLQP SVAQPQIEAI PSALADVV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..344] PSI-BLAST 8.154902 Heavy meromyosin subfragment
    2 View Details [345..1253] PSI-BLAST 153.0 Exonuclease domain of family B (archaeal and phage) DNA polymerases; T4-like DNA polymerase
    3 View Details [1254..1488] Pfam 25.346787 No description for PF08996.1 was found. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • DNA-directed DNA polymerase activity
    		•  11.2781960093187 bayes_pls_golite062009
  • DNA polymerase activity
    		•  11.2285838712952 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  8.85826259809475 bayes_pls_golite062009
  • DNA primase activity
    		•  8.57378684936335 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.79232184185512 bayes_pls_golite062009
  • transferase activity
    		•  4.02382113115178 bayes_pls_golite062009
  • RNA polymerase activity
    		•  2.29514625858236 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  2.29514625858236 bayes_pls_golite062009
  • ribonuclease activity
    		•  2.10426652514018 bayes_pls_golite062009
  • exonuclease activity
    		•  1.68989335095363 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.62213678119562 bayes_pls_golite062009
  • DNA binding
    		•  1.55767764828811 bayes_pls_golite062009
  • binding
    		•  1.23825244840872 bayes_pls_golite062009
  • damaged DNA binding
    		•  1.08077297289305 bayes_pls_golite062009
  • catalytic activity
    		•  1.04899053677564 bayes_pls_golite062009
  • endonuclease activity
    		•  0.991569665925888 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.863544378011356 bayes_pls_golite062009
  • exoribonuclease activity
    		•  0.85780161294346 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.78558451404229 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.78013028675591 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  0.48776342704945 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.433956339585542 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  0.43313823287883 bayes_pls_golite062009
  • chromatin binding
    		•  0.382725239240319 bayes_pls_golite062009
  • protein binding
    		•  0.377121823388117 bayes_pls_golite062009
  • nuclease activity
    		•  0.332024848299731 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.283883977748512 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.262305398570872 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.206750180223289 bayes_pls_golite062009
  • single-stranded DNA specific exodeoxyribonuclease activity
    		•  0.19596408995795 bayes_pls_golite062009
  • endoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.193854882336037 bayes_pls_golite062009
  • 5'-3' exonuclease activity
    		•  0.154583332107704 bayes_pls_golite062009
  • transcription factor activity
    		•  0.093362945686819 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0873722112846369 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0504884604991491 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0416785534748089 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.039082818442797 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle