YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: DNApol-alpha180-PA
Organism: Drosophila melanogaster
Length: 1488 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DNApol-alpha180-PA.

Description E-value Query
Range		 Subject
Range
gi|259790 - gi|259790|gb|AAB24152.1| DNA polymerase-primase 180 kda subunit [Drosophila melanogaster]
 1116.0 [0..1] [1488..1]

Back

Predicted Domain #1
Region A:
Residues: [1-344] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSESPSEPRA KRQRVDKNGR FAAMERLRQL KGTKNKCKVE DQVDDVYDVV DEREYAKRAQ  60
   61 EKYGDDWIEE DGTGYAEDLR DFFEDEDEYS DGEEDRKDSK KKKGVAPNSK KRPRENEKPV 120
  121 TGKASIKNLF SNAVPKKMDV KTSVKDDDIL ADILGEIKEE PAATSEKAEK VIAPAKISVT 180
  181 SRKFDAAAAK EYMNSFLNNI KVQEQERKKA EASSDNEMLE RILKPKAAVP NTKVAFFSSP 240
  241 TIKKEPMPEK TPAKKATEDP FSDNEMDFSC LDDDENQFDV EKTQQTEKVS QTKTAAEKTS 300
  301 QSKVAEKSAP KKETTGSPKE SESEDISRLL NNWESICQMD DDFE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.154902
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [345-1253] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSVLTTEQDS TISSDQQLRF WYWEAYEDPV KMPGEVFLFG RTADGKSVCL RVQNINRVLY  60
   61 LLPRQFLLDP ISKEPTKQKV TVADIYKEFD SEVANQLKLE FFRSRKVTKS FAHHAIGIEV 120
  121 PQSCDYLEVH YDGKKPLPNL SADKKYNSIA HIFGATTNAL ERFLLDRKIK GPCWLQVTGF 180
  181 KVSPTPMSWC NTEVTLTEPK NVELVQDKGK PAPPPPLTLL SLNVRTSMNP KTSRNEICMI 240
  241 SMLTHNRFHI DRPAPQPAFN RHMCALTRPA VVSWPLDLNF EMAKYKSTTV HKHDSERALL 300
  301 SWFLAQYQKI DADLIVTFDS MDCQLNVITD QIVALKIPQW SRMGRLRLSQ SFGKRLLEHF 360
  361 VGRMVCDVKR SAEECIRARS YDLQTLCKQV LKLKESERME VNADDLLEMY EKGESITKLI 420
  421 SLTMQDNSYL LRLMCELNIM PLALQITNIC GNTMTRTLQG GRSERNEFLL LHAFHEKNYI 480
  481 VPDKKPVSKR SGAGDTDATL SGADATMQTK KKAAYAGGLV LEPMRGLYEK YVLLMDFNSL 540
  541 YPSIIQEYNI CFTTVQQPVD ADELPTLPDS KTEPGILPLQ LKRLVESRKE VKKLMAAPDL 600
  601 SPELQMQYHI RQMALKLTAN SMYGCLGFAH SRFFAQHLAA LVTHKGREIL TNTQQLVQKM 660
  661 NYDVVYGDTD SLMINTNITD YDQVYKIGHN IKQSVNKLYK QLELDIDGVF GCLLLLKKKK 720
  721 YAAIKLSKDS KGNLRREQEH KGLDIVRRDW SQLAVMVGKA VLDEVLSEKP LEEKLDAVHA 780
  781 QLEKIKTQIA EGVVPLPLFV ITKQLTRTPQ EYANSASLPH VQVALRMNRE RNRRYKKGDM 840
  841 VDYVICLDGT TNAAMQRAYH LDELKTSEDK KLQLDTNYYL GHQIHPVVTR MVEVLEGTDA 900
  901 SRIAECLGM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 153.0
Match: 1qhtA
Description: Exonuclease domain of family B (archaeal and phage) DNA polymerases; T4-like DNA polymerase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA-directed DNA polymerase activity 11.2781960093187 bayes_pls_golite062009
DNA polymerase activity 11.2285838712952 bayes_pls_golite062009
nucleotidyltransferase activity 8.85826259809475 bayes_pls_golite062009
DNA primase activity 8.57378684936335 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.79232184185512 bayes_pls_golite062009
transferase activity 4.02382113115178 bayes_pls_golite062009
RNA polymerase activity 2.29514625858236 bayes_pls_golite062009
DNA-directed RNA polymerase activity 2.29514625858236 bayes_pls_golite062009
ribonuclease activity 2.10426652514018 bayes_pls_golite062009
exonuclease activity 1.68989335095363 bayes_pls_golite062009
nucleic acid binding 1.62213678119562 bayes_pls_golite062009
DNA binding 1.55767764828811 bayes_pls_golite062009
binding 1.23825244840872 bayes_pls_golite062009
damaged DNA binding 1.08077297289305 bayes_pls_golite062009
catalytic activity 1.04899053677564 bayes_pls_golite062009
endonuclease activity 0.991569665925888 bayes_pls_golite062009
transcription regulator activity 0.863544378011356 bayes_pls_golite062009
exoribonuclease activity 0.85780161294346 bayes_pls_golite062009
3'-5' exonuclease activity 0.78558451404229 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 0.78013028675591 bayes_pls_golite062009
endodeoxyribonuclease activity 0.48776342704945 bayes_pls_golite062009
structure-specific DNA binding 0.433956339585542 bayes_pls_golite062009
3'-5'-exoribonuclease activity 0.43313823287883 bayes_pls_golite062009
chromatin binding 0.382725239240319 bayes_pls_golite062009
protein binding 0.377121823388117 bayes_pls_golite062009
nuclease activity 0.332024848299731 bayes_pls_golite062009
DNA helicase activity 0.283883977748512 bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.262305398570872 bayes_pls_golite062009
single-stranded DNA binding 0.206750180223289 bayes_pls_golite062009
single-stranded DNA specific exodeoxyribonuclease activity 0.19596408995795 bayes_pls_golite062009
endoribonuclease activity, producing 5'-phosphomonoesters 0.193854882336037 bayes_pls_golite062009
5'-3' exonuclease activity 0.154583332107704 bayes_pls_golite062009
transcription factor activity 0.093362945686819 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0873722112846369 bayes_pls_golite062009
pyrophosphatase activity 0.0504884604991491 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0416785534748089 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.039082818442797 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [1254-1488] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPTKFRQNAQ RTQRENTEQS EGESLLKTTL QLYRLCEPFR FQCVTCKTEQ LMASAYRPGP  60
   61 SNSHIAVLQQ CAKSECQTAP IQYLASVRNQ LQLSMRQYVQ RFYKNWLVCD HPDCNFNTRT 120
  121 HSLRKKSHRP LCQKCRSGSL LRQYTERDLY NQLCYLRFMF DLGKQTLQQK PTLTPELEQA 180
  181 YQLLYETVDQ QLQSSSYVII SLSKLFARSL AQMSLQPSVA QPQIEAIPSA LADVV

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 25.346787
Match: PF08996.1
Description: No description for PF08996.1 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle