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Protein Overview: tin-PA

General Information:
Name(s) found: tin-PA / FBpp0083485 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene tinman is referred to in FlyBase by the symbol Dmel\tin (CG7895, FBgn0004110). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:17204701..17207692. It has the cytological map location 93D9. Based on sequence similarity, it is predicted to have molecular function</span>: RNA polymerase II transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: cardioblast differentiation; gonadal mesoderm development; germ cell migration; embryonic heart tube development; pericardial cell differentiation; cardiac cell differentiation; lymph gland development; salivary gland morphogenesis; mesoderm development; cardiac muscle cell differentiation. 58 alleles are reported. The phenotypes of these alleles are annotated with 42 unique terms, many of which group under: organ system; primordium; late extended germ band embryo; hypodermal muscle of larval abdomen; abdominal transverse muscle; midgut constriction; embryonic nervous system; embryonic/larval dorsal vessel; nervous system; adult. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 416 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS][NAS]
    Biological Process: pole cell migration [TAS]
    cardiac cell differentiation [IMP][TAS]
    mesoderm development [IEP][NAS][TAS]
    cardioblast cell fate determination [TAS]
    regulation of transcription, DNA-dependent [IEA]
    germ cell migration [IMP][TAS]
    metamorphosis [TAS]
    embryonic heart tube development [IMP]
    regulation of transcription [IEA][ISS]
    pericardial cell differentiation [IMP]
    somatic muscle development [NAS]
    visceral muscle development [NAS]
    mesodermal cell fate specification [TAS]
    salivary gland morphogenesis [IMP]
    gonadal mesoderm development [IMP]
    heart development [TAS]
    gonad development [TAS]
    negative regulation of transcription, DNA-dependent [TAS]
    positive regulation of transcription, DNA-dependent [TAS]
    lymph gland development [IMP]
    cell fate specification [NAS]
    cardioblast differentiation [IMP]
    cardiac muscle cell differentiation [IMP]
    Molecular Function: transcription factor activity [IEA]
    RNA polymerase II transcription factor activity [ISS]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLQHHQQQAQ SGGYYDHYTQ SPSPGSLTNA DALNTTPFSV KDILNMVNQT EAYEGSYGHI  60
   61 DGAATASALF AAGEYQNPHQ YLNHQQHQQS ELPIPQQQLH HQHLDDGATT SSSLSPLLPP 120
  121 PPHQLYGGYQ DYGMPAHMFQ HHHGHPHQSF QHSASAYNMS ASQFYAGASA TAYQTPATYN 180
  181 YNYAGSGEVY GGATPSAVGI KSEYIPTPYV TPSPTLDLNS SAEVDSLQAP TQKLCVNPLS 240
  241 QRLMETASNS SSLRSIYGSD EGAKKKDNSQ VTSSRSELRK NSISGNSNPG SNSGSTKPRM 300
  301 KRKPRVLFSQ AQVLELECRF RLKKYLTGAE REIIAQKLNL SATQVKIWFQ NRRYKSKRGD 360
  361 IDCEGIAKHL KLKSEPLDSP TSLPPPIPNH VMWPPTMQQS QQQQQHHAQQ QQMQHM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..204] MSA 10.289997 View MSA. No confident structure predictions are available.
    2 View Details [205..299] deduced N/A No confident structure predictions are available.
    3 View Details [300..416] PSI-BLAST 22.522879 Crystal Structure of HoxA9 and Pbx1 homeodomains bound to DNA

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.55154985983449 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.5139760613123 bayes_pls_golite062009
  • transcription activator activity
    		•  3.10621734076555 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.26183812259792 bayes_pls_golite062009
  • protein binding
    		•  1.88087411289001 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.49423102874486 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.14886080629275 bayes_pls_golite062009
  • chromatin binding
    		•  1.04132983826241 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.13444271681002 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle