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View Structure Prediction Details

Protein: tin-PA
Organism: Drosophila melanogaster
Length: 416 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tin-PA.

Description E-value Query
Range
Subject
Range
gi|123392, gi|103204 - sp|P22711|HMTI_DROME Muscle-specific homeobox protein tinman (Msh-2) (NK-4), pir||A43561 homeotic p...
gi|10346 - gi|10346|emb|CAA38978.1| msh-2 [Drosophila sp.]
144.0 [0..1] [396..1]

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Predicted Domain #1
Region A:
Residues: [1-204]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLQHHQQQAQ SGGYYDHYTQ SPSPGSLTNA DALNTTPFSV KDILNMVNQT EAYEGSYGHI  60
   61 DGAATASALF AAGEYQNPHQ YLNHQQHQQS ELPIPQQQLH HQHLDDGATT SSSLSPLLPP 120
  121 PPHQLYGGYQ DYGMPAHMFQ HHHGHPHQSF QHSASAYNMS ASQFYAGASA TAYQTPATYN 180
  181 YNYAGSGEVY GGATPSAVGI KSEY

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [205-299]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPTPYVTPSP TLDLNSSAEV DSLQAPTQKL CVNPLSQRLM ETASNSSSLR SIYGSDEGAK  60
   61 KKDNSQVTSS RSELRKNSIS GNSNPGSNSG STKPR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [300-416]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKRKPRVLFS QAQVLELECR FRLKKYLTGA EREIIAQKLN LSATQVKIWF QNRRYKSKRG  60
   61 DIDCEGIAKH LKLKSEPLDS PTSLPPPIPN HVMWPPTMQQ SQQQQQHHAQ QQQMQHM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.522879
Match: 1pufA
Description: Crystal Structure of HoxA9 and Pbx1 homeodomains bound to DNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
transcription repressor activity 3.55154985983449 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
transcription corepressor activity 1.49423102874486 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.14886080629275 bayes_pls_golite062009
chromatin binding 1.04132983826241 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.13444271681002 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle