YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: tin-PA
Organism: Drosophila melanogaster
Length: 416 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tin-PA.

Description E-value Query
Range
Subject
Range
gi|123392, gi|103204 - sp|P22711|HMTI_DROME Muscle-specific homeobox protein tinman (Msh-2) (NK-4), pir||A43561 homeotic p...
gi|10346 - gi|10346|emb|CAA38978.1| msh-2 [Drosophila sp.]
144.0 [0..1] [396..1]

Back

Predicted Domain #1
Region A:
Residues: [1-204]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLQHHQQQAQ SGGYYDHYTQ SPSPGSLTNA DALNTTPFSV KDILNMVNQT EAYEGSYGHI  60
   61 DGAATASALF AAGEYQNPHQ YLNHQQHQQS ELPIPQQQLH HQHLDDGATT SSSLSPLLPP 120
  121 PPHQLYGGYQ DYGMPAHMFQ HHHGHPHQSF QHSASAYNMS ASQFYAGASA TAYQTPATYN 180
  181 YNYAGSGEVY GGATPSAVGI KSEY

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [205-299]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPTPYVTPSP TLDLNSSAEV DSLQAPTQKL CVNPLSQRLM ETASNSSSLR SIYGSDEGAK  60
   61 KKDNSQVTSS RSELRKNSIS GNSNPGSNSG STKPR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [300-416]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKRKPRVLFS QAQVLELECR FRLKKYLTGA EREIIAQKLN LSATQVKIWF QNRRYKSKRG  60
   61 DIDCEGIAKH LKLKSEPLDS PTSLPPPIPN HVMWPPTMQQ SQQQQQHHAQ QQQMQHM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.522879
Match: 1pufA
Description: Crystal Structure of HoxA9 and Pbx1 homeodomains bound to DNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
transcription repressor activity 3.55154985983449 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
transcription corepressor activity 1.49423102874486 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.14886080629275 bayes_pls_golite062009
chromatin binding 1.04132983826241 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.13444271681002 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle