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Protein Overview: Cbp20-PA

General Information:
Name(s) found: Cbp20-PA / FBpp0082973 [FlyBase]
Description(s) found:
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  • gi|7300337|gb|AAF55496.1| cap binding protein 20 [Drosophila melanogaster] [NCBI NR]
  • gi|5763573|emb|CAB53185.1| cap binding protein 20 [Drosophila melanogaster] [NCBI NR]
  • gi|17944312|gb|AAL48049.1| RE12122p [Drosophila melanogaster] [NCBI NR]
  • gi|17738031|ref|NP_524396.1| cap binding protein 20 [Drosophila melanogaster] [NCBI NR]
  • Nuclear cap-binding protein subunit 2 OS=Drosophila melanogaster GN=Cbp20 PE=1 SV=1 [Swiss-Prot]
  • The gene cap binding protein 20 is referred to in FlyBase by the symbol Dmel\Cbp20 (CG12357, FBgn0022943). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:13990385..13991161. It has the cytological map location 90F4. Based on sequence similarity, it is predicted to have molecular function</span>: RNA cap binding; mRNA binding. There is experimental evidence that it is involved in the biological process</span>: production of siRNA involved in RNA interference; negative regulation of viral genome replication; gene silencing by miRNA. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG12357-PA translation from_gene[CG12357 Cbp20 FBgn0022943] seq_release:3 mol_weight=17719 cds_boundaries:(3R:13,990,466..13,991,106[+]) aa_length:154 transcript_info:[CG12357-RA seq_release:3] gene_info:[gene symbol:Cbp20 FBgn0022943 gene_boundaries: [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9V3L6) CBP20 protein (RE12122p) [DrosMelano7227.FASTAC.txt]
  • (AE003721) Cbp20 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG12357-PA [Drosophila melanogaster]gi|17944312|gb|AAL48049.1| RE12122p [Drosophila melanogaster]gi|17738031|ref|NP_524396.1| CG12357-PA [Drosophila melanogaster]gi|5763573|emb|CAB53185.1| cap binding protein 20 [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:join(13990451..13990498,13990554..13990771,13990896..13991094); ID=FBpp0082973; name=Cbp20-PA; parent=FBgn0022943,FBtr0083551; dbxref=FlyBase:FBpp0082973,FlyBase_Annotation_IDs:CG12357-PA,GB_protein:AAF55496.1,REFSEQ:NP_524396,GB_prot [fly-100309-contam.fasta]
  • CG12357-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • cap binding protein 20 CG12357-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • cap binding protein 20 [Drosophila melanogaster] [nr-271106-contam.fasta]
  • RE12122p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:join(13990451..13990498,13990554..13990771,13990896..13991094); ID=FBpp0082973; name=Cbp20-PA; parent=FBgn0022943,FBtr0083551; dbxref=FlyBase:FBpp0082973,FlyBase_Annotation_IDs:CG12357-PA,GB_protein:AAF55496.1,REFSEQ:NP_524396,GB_protein:AAF55496; MD5=8a565b03fcc905b57b989b817bb01675; length=154; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:join(13990451..13990498,13990554..13990771,13990896..13991094); ID=FBpp0082973; name=Cbp20-PA; parent=FBgn0022943,FBtr0083551; dbxref=FlyBase:FBpp0082973,FlyBase_Annotation_IDs:CG12357-PA,GB_protein:AAF55496.1,REFSEQ:NP_524396,GB_protein:AAF55496; MD5=8a565b03fcc905b57b989b817bb01675; length=154; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=3R:join(13990451..13990498,13990554..13990771,13990896..13991094); ID=FBpp0082973; name=Cbp20-PA; parent=FBgn0022943,FBtr0083551; dbxref=FlyBase:FBpp0082973,FlyBase_Annotation_IDs:CG12357-PA,GB_protein:AAF55496.1,REFSEQ:NP_524396,GB_protein:AAF55496,FlyMine:FBpp0082973,modMine:FBpp0082973; MD5=8a565b03fcc905b57b989b817bb01675; length=154; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:join(18164729..18164776,18164832..18165049,18165174..18165372); ID=FBpp0082973; name=Cbp20-PA; parent=FBgn0022943,FBtr0083551; dbxref=FlyBase:FBpp0082973,FlyBase_Annotation_IDs:CG12357-PA,GB_protein:AAF55496.1,REFSEQ:NP_524396,GB_protein:AAF55496,FlyMine:FBpp0082973,modMine:FBpp0082973; MD5=8a565b03fcc905b57b989b817bb01675; length=154; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:join(18164729..18164776,18164832..18165049,18165174..18165372); ID=FBpp0082973; name=Cbp20-PA; parent=FBgn0022943,FBtr0083551; dbxref=FlyBase:FBpp0082973,FlyBase_Annotation_IDs:CG12357-PA,GB_protein:AAF55496.1,REFSEQ:NP_524396,GB_protein:AAF55496,FlyMine:FBpp0082973,modMine:FBpp0082973; MD5=8a565b03fcc905b57b989b817bb01675; length=154; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0082973 type=protein; loc=3R:join(18164729..18164776,18164832..18165049,18165174..18165372); ID=FBpp0082973; name=Cbp20-PA; parent=FBgn0022943,FBtr0083551; dbxref=FlyBase:FBpp0082973,FlyBase_Annotation_IDs:CG12357-PA,GB_protein:AAF55496.1,REFSEQ:NP_524396,GB_protein:AAF55496,FlyMine:FBpp0082973,modMine:FBpp0082973; MD5=8a565b03fcc905b57b989b817bb01675; length=154; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:join(18164729..18164776,18164832..18165049,18165174..18165372); ID=FBpp0082973; name=Cbp20-PA; parent=FBgn0022943,FBtr0083551; dbxref=FlyBase:FBpp0082973,FlyBase_Annotation_IDs:CG12357-PA,GB_protein:AAF55496.1,REFSEQ:NP_524396,GB_protein:AAF55496,UniProt/Swiss-Prot:Q9V3L6,FlyMine:FBpp0082973,modMine:FBpp0082973; MD5=8a565b03fcc905b57b989b817bb01675; length=154; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 154 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    nuclear cap binding complex [ISS]
    catalytic step 2 spliceosome [IDA]
    precatalytic spliceosome [IDA]
    spliceosomal complex [ISS]
    Biological Process: gene silencing by miRNA [IMP]
    production of siRNA involved in RNA interference [IMP]
    negative regulation of viral genome replication [IMP]
    nuclear mRNA splicing, via spliceosome [IC][ISS]
    Molecular Function: nucleotide binding [IEA]
    RNA cap binding [ISS]
    mRNA binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFASVELSSY RDQHFKGSRS EQERSLRDSC TLYVGNLSFY TTEEQIHELF SRCGDVRVIV  60
   61 MGLDKYKKTP CGFCFVEYYV RSEAEAAMRF VNGTRLDDRL IRVDWDAGFV EGRQYGRGKT 120
  121 GGQVRDEYRT DYDAGRGGYG KLLSQKIAPN TDNR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..154] PSI-BLAST 25.045757 CBP20, 20KDa nuclear cap-binding protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  6.73097473547076 bayes_pls_golite062009
    		• 6.62953239642182 bayes_pls_golite062009
  • RNA cap binding
    		•  5.43390507836051 bayes_pls_golite062009
  • mRNA binding
    		•  5.29759606920196 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.81920018903278 bayes_pls_golite062009
  • binding
    		•  3.64400841800969 bayes_pls_golite062009
  • snRNA binding
    		•  3.28448936696877 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  3.11990160533699 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  2.93798024346416 bayes_pls_golite062009
  • U1 snRNA binding
    		•  2.26303528058407 bayes_pls_golite062009
  • structural molecule activity
    		•  1.29928829870122 bayes_pls_golite062009
  • protein binding
    		•  1.12215421354121 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.07788694919471 bayes_pls_golite062009
  • DNA binding
    		•  0.978604858165557 bayes_pls_golite062009
  • transporter activity
    		•  0.628672636801176 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.591700155096213 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.505106991526286 bayes_pls_golite062009
  • transcription factor activity
    		•  0.234742017105535 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.182749906784328 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.096231856558874 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.059732432409948 bayes_pls_golite062009
  • snoRNA binding
    		•  0.0568636182001701 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0510390778764699 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0484248928275733 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle