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Protein Overview: SF1-PA

General Information:
Name(s) found: SF1-PA / FBpp0082897 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene Splicing factor 1 is referred to in FlyBase by the symbol Dmel\SF1 (CG5836, FBgn0025571). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:13366145..13370873. It has the cytological map location 90B4. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: RNA binding; zinc ion binding. There is experimental evidence that it is involved in the biological process</span>: inter-male aggressive behavior. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 787 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    precatalytic spliceosome [IDA]
    spliceosomal complex [ISS][NAS]
    Biological Process: inter-male aggressive behavior [IMP]
    nuclear mRNA splicing, via spliceosome [IC][ISS][NAS]
    Molecular Function: zinc ion binding [IEA]
    RNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSATPPDLLS LAASREVSAA VAVAASANGG SGRSADKERS RSRDRGRDKD KDRDKDRKKR  60
   61 DKDSRDRDSR RRDDRGDRDR DRERDRDSRS HRSKSRNYDD GDRRRKRSRS RDRDRDRKRD 120
  121 RDRDSRSRRS SSRGGRDDYD RSRRRRSRSR SYERRRNDRG SQRDQRDQHS QRSSRERTHV 180
  181 NPFDTSNSRN SLNQDHDQSR IPSLFDRQQG LETIREEGRE QRFDLTQTIQ ELMGNAGGNK 240
  241 GFASFFNSQN SNDSTSNGAF DNSADSAAER KRKRKSRWGG SENDKTFIPG MPTILPSTLD 300
  301 PAQQEAYLVQ FQIEEISRKL RTGDLGITQN PEERSPSPEP IYSSDGKRLN TREFRYRKRL 360
  361 EEQRHQLIVK MQTVNPEFKP PADYKPPVTR VSDKVLIPQE QHPDINFVGL LIGPRGNTLK 420
  421 AMEKDTGAKI IIRGKGSVKE GKVGRKDGQP LPGEDEPLHA FITAPNPEAV RKAVDKIKDV 480
  481 IRQGIEVPEG HNDLRRMQLR ELAQLNGTLR ENDIQRCTCG STDHKSWQCP DKPIITNTIV 540
  541 CTSCGGTGHL TKDCRNKRPG SGVPGMACED SQAKIDEEYM SLMAELGEGP PPPSASAKTD 600
  601 PPASNGPQLH RASYSIFDKK PSQMQAIQSP PSSSSRDHQR DLGGWGAAAH EHGMGMEHGM 660
  661 GLDQHGHGLA AMDHGMSLGM EHAMAAYVPA PPGTQAPPPM PPPLMPWMSA PQPPPPATEP 720
  721 LNPPIPGTLP PLIPPPPGTS APPMPPWGGG AYSGWGGGYA PPPPPPCAPP PPALSLSQPP 780
  781 PPPPPSA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..236] MSA 5.052995 View MSA. No confident structure predictions are available.
    2 View Details [237..338] deduced N/A No confident structure predictions are available.
    3 View Details [339..510] PSI-BLAST 39.30103 RNA splicing factor 1
    4 View Details [511..787] PSI-BLAST 20.0 No description for 1y0fB was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • nucleic acid binding
    		•  4.28581120742478 bayes_pls_golite062009
  • RNA binding
    		•  4.07234389285213 bayes_pls_golite062009
  • binding
    		•  3.45962790790935 bayes_pls_golite062009
  • mRNA binding
    		•  2.74771386314615 bayes_pls_golite062009
  • protein binding
    		•  2.21586499514642 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.01194399592256 bayes_pls_golite062009
  • DNA binding
    		•  1.78469836520678 bayes_pls_golite062009
  • transcription factor activity
    		•  0.866815968834173 bayes_pls_golite062009
    		• 0.649281624091344 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.64468203163713 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.594072241231183 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.28490151670131 bayes_pls_golite062009
  • transcription activator activity
    		•  0.210494225017032 bayes_pls_golite062009
  • transcription factor binding
    		•  0.139588254197875 bayes_pls_golite062009
  • catalytic activity
    		•  0.113112541746059 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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