Protein Overview: Dad-PC, Dad-PB, ...

General Information:
Name(s) found:	Dad-PC / FBpp0099512 [FlyBase] Dad-PB / FBpp0082835 [FlyBase] Dad-PA / FBpp0082834 [FlyBase]
Description(s) found: Found 47 descriptions. SHOW ALL	The gene Daughters against dpp is referred to in FlyBase by the symbol Dmel\Dad (CG5201, FBgn0020493). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:12879729..12896135. It has the cytological map location 89E11. There is experimental evidence that it has the molecular function</span>: transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity. There is experimental evidence that it is involved in the biological process</span>: germ-line stem cell maintenance; negative regulation of muscle organ development; morphogenesis of larval imaginal disc epithelium; eye-antennal disc development; retinal ganglion cell axon guidance; negative regulation of transforming growth factor beta receptor signaling pathway; imaginal disc-derived wing morphogenesis; anterior/posterior pattern formation, imaginal disc. 30 alleles are reported. The phenotypes of these alleles are annotated with 29 unique terms, many of which group under: organ system; adult segment; multi-cell-component structure; adult mesothoracic segment; nervous system; thoracic segment; egg; chorion; dorsal thoracic disc; portion of tissue. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase] The gene Daughters against dpp is referred to in FlyBase by the symbol Dmel\Dad (CG5201, FBgn0020493). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:12879729..12896135. It has the cytological map location 89E11. There is experimental evidence that it has the molecular function</span>: transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity. There is experimental evidence that it is involved in the biological process</span>: germ-line stem cell maintenance; negative regulation of muscle organ development; morphogenesis of larval imaginal disc epithelium; eye-antennal disc development; retinal ganglion cell axon guidance; negative regulation of transforming growth factor beta receptor signaling pathway; imaginal disc-derived wing morphogenesis; anterior/posterior pattern formation, imaginal disc. 30 alleles are reported. The phenotypes of these alleles are annotated with 29 unique terms, many of which group under: organ system; adult segment; multi-cell-component structure; adult mesothoracic segment; nervous system; thoracic segment; egg; chorion; dorsal thoracic disc; portion of tissue. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase] The gene Daughters against dpp is referred to in FlyBase by the symbol Dmel\Dad (CG5201, FBgn0020493). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:12879729..12896135. It has the cytological map location 89E11. There is experimental evidence that it has the molecular function</span>: transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity. There is experimental evidence that it is involved in the biological process</span>: germ-line stem cell maintenance; negative regulation of muscle organ development; morphogenesis of larval imaginal disc epithelium; eye-antennal disc development; retinal ganglion cell axon guidance; negative regulation of transforming growth factor beta receptor signaling pathway; imaginal disc-derived wing morphogenesis; anterior/posterior pattern formation, imaginal disc. 30 alleles are reported. The phenotypes of these alleles are annotated with 29 unique terms, many of which group under: organ system; adult segment; multi-cell-component structure; adult mesothoracic segment; nervous system; thoracic segment; egg; chorion; dorsal thoracic disc; portion of tissue. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	568 amino acids
Gene Ontology:
Cellular Component:	transcription factor complex [IEA]
Biological Process:	retinal ganglion cell axon guidance [IMP] germ-line stem cell maintenance [IMP] imaginal disc-derived wing morphogenesis [IMP] regulation of transcription, DNA-dependent [IEA] negative regulation of muscle organ development [IMP] regulation of transforming growth factor beta receptor signaling pathway [ISS] anterior/posterior pattern formation, imaginal disc [IMP] eye-antennal disc development [IMP] negative regulation of transforming growth factor beta receptor signaling pathway [IGI][IMP][TAS] morphogenesis of larval imaginal disc epithelium [IMP]
Molecular Function:	transcription factor activity [IEA] protein binding [IEA] transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity [IGI][TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIFPREKKVL WRYASSNNPS NGVSAAPPAQ PPRPPPPPHR PRPHQCTPSF GYSCNEEDSL  60
   61 AMRQTPLPPY SSIACGMDCS SSNSSSCGQS LSLSQGQGHN NNNSHPYRRL PNHMDVLPPP 120
  121 PSACDRCCTA PGYSCASSCD DMLIDGSDLD QDRSPDQGQV QPVDRRMISA TTFTTMFRKC 180
  181 CGGATESTSG STLTIPVSTS RATAHPPQTQ AQNGKRFRED FEALMKQLKR KQRNELLLAV 240
  241 KSRLDPPTKT QRDVVEPTTT TAPTYLQCIL IPCKTQTVWE PHVTASRLFF WRELWNAKEL 300
  301 KRLPTCPAAR DCIYMCCNPL HWFRILHQPE TESPTPPYQR SKMLRLKDAD FEEDSQNDAK 360
  361 SAALSTWSAE STSISNIYKP ALYESVTTDG KDHNINSQVW CQIAYWEMAH RVGEFFHAKT 420
  421 NAVNIYTDGI VASEVDSMCL RDLTPAGNQI HSVVPKARHT VGLGVTLSLE NGDVWIYNRG 480
  481 NTTIFVDSPT LSENLDRVCK VMPGYCLKAF ETNRAELLSM RDHGHHPMGP VDYFSIKISF 540
  541 GKGWGRDYKR QDIMGCPCWL EVHFSHLR

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

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Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
R-SMAD binding	5.38307893104629	bayes_pls_golite062009
transforming growth factor beta receptor, cytoplasmic mediator activity	5.17758651944685	bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase signaling protein activity	4.95270065635384	bayes_pls_golite062009
co-SMAD binding	4.57538059815089	bayes_pls_golite062009
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity	4.49077041445033	bayes_pls_golite062009
ubiquitin-protein ligase activity	4.40792626415753	bayes_pls_golite062009
SMAD binding	4.23556933524744	bayes_pls_golite062009
small conjugating protein ligase activity	4.11302084276027	bayes_pls_golite062009
binding	3.6561903894619	bayes_pls_golite062009
transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity	3.61855740138956	bayes_pls_golite062009
transcription regulator activity	3.49687772656017	bayes_pls_golite062009
protein binding	3.44553762357492	bayes_pls_golite062009
DNA binding	3.30334070294767	bayes_pls_golite062009
type I transforming growth factor beta receptor binding	3.25693690222359	bayes_pls_golite062009
nucleic acid binding	3.21526555447097	bayes_pls_golite062009
acid-amino acid ligase activity	3.11943104361829	bayes_pls_golite062009
receptor signaling protein activity	3.08220855629618	bayes_pls_golite062009
transcription activator activity	2.94935902482394	bayes_pls_golite062009
receptor serine/threonine kinase binding	2.94401714632865	bayes_pls_golite062009
signal transducer activity	2.90288654612667	bayes_pls_golite062009
molecular transducer activity	2.90288654612667	bayes_pls_golite062009
sequence-specific DNA binding	2.88406197124131	bayes_pls_golite062009
activin binding	2.85561990563659	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.61166537801555	bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding	2.57320437127906	bayes_pls_golite062009
transforming growth factor beta receptor binding	2.57320437127906	bayes_pls_golite062009
phosphatase activity	2.46582579847871	bayes_pls_golite062009
phosphoric ester hydrolase activity	2.41505949322677	bayes_pls_golite062009
promoter binding	2.30493918456602	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	2.1294440466744	bayes_pls_golite062009
transcription factor activity	2.08449567315174	bayes_pls_golite062009
collagen binding	1.9825610927799	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.88096476099716	bayes_pls_golite062009
kinase activity	1.82476774968305	bayes_pls_golite062009
transcription repressor activity	1.74929788315626	bayes_pls_golite062009
protein kinase activity	1.73373132141588	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.66058356077795	bayes_pls_golite062009
transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	1.61493700485683	bayes_pls_golite062009
I-SMAD binding	1.6033600450778	bayes_pls_golite062009
chromatin binding	1.44267609273288	bayes_pls_golite062009
small conjugating protein binding	1.3559369584113	bayes_pls_golite062009
structure-specific DNA binding	1.32552524966562	bayes_pls_golite062009
transferase activity	1.29860325699399	bayes_pls_golite062009
ubiquitin binding	1.28191134965346	bayes_pls_golite062009
double-stranded DNA binding	1.21988722144674	bayes_pls_golite062009
protein serine/threonine kinase activity	1.1868962075754	bayes_pls_golite062009
receptor binding	1.1261895404991	bayes_pls_golite062009
cell adhesion molecule binding	1.10293974101617	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	1.02636679142543	bayes_pls_golite062009
histone binding	1.01074250987871	bayes_pls_golite062009
transcription factor binding	0.95553719139833	bayes_pls_golite062009
ubiquitin protein ligase binding	0.85140744915405	bayes_pls_golite062009
hydrolase activity	0.711787881321496	bayes_pls_golite062009
RNA binding	0.403713641965787	bayes_pls_golite062009
enzyme binding	0.34998623523914	bayes_pls_golite062009
protein dimerization activity	0.33340925100096	bayes_pls_golite062009
specific transcriptional repressor activity	0.15013949452504	bayes_pls_golite062009
identical protein binding	0.0513801649373811	bayes_pls_golite062009
protein homodimerization activity	0.0339057097360133	bayes_pls_golite062009

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.95

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..125]	deduced	N/A	No confident structure predictions are available.
2	View Details	[126..339]	PSI-BLAST	43.0	Crystal structure of Smad3-MH1 bound to DNA at 2.4 A resolution
3	View Details	[340..568]	PSI-BLAST	80.221849	Smad2 MH2 domain

Protein Overview: Dad-PC, Dad-PB, ...

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: