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Protein Overview: abd-A-PB

General Information:
Name(s) found: abd-A-PB / FBpp0082829 [FlyBase]
Description(s) found:
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  • gi|969083|gb|AAA84405.1| ABD-AII [NCBI NR]
  • gi|24647534|ref|NP_732176.1| abdominal A, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|23171502|gb|AAF55360.2| abdominal A, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|1708230|sp|P29555.2|ABDA_DROME RecName: Full=Homeobox protein abdominal-A [NCBI NR]
  • (P29555) Homeobox protein abdominal-A [Swiss-Prot]
  • Homeobox protein abdominal-A OS=Drosophila melanogaster GN=abd-A PE=2 SV=2 [Swiss-Prot]
  • The gene abdominal A is referred to in FlyBase by the symbol Dmel\abd-A (CG10325, FBgn0000014). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:12633349..12655769. It has the cytological map location 89E2. There is experimental evidence that it has the molecular function</span>: transcription factor activity; sequence-specific DNA binding; RNA polymerase II transcription factor activity, enhancer binding. There is experimental evidence for 19 unique biological process</span> terms, many of which group under: anatomical structure development; organ development; regulation of metabolic process; reproductive process in a multicellular organism; programmed cell death; positive regulation of cellular biosynthetic process; regulation of developmental process; cellular process; oenocyte development; gonadal mesoderm development; neuroblast fate commitment. 89 alleles are reported. The phenotypes of these alleles are annotated with 108 unique terms, many of which group under: organ system; adult segment; peripheral nervous system; nervous system; thoracic segment; abdominal ventral denticle belt; primordium; late extended germ band embryo; embryonic/larval dorsal vessel; midgut constriction. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • >CG10325-PB translation from_gene[CG10325 abd-A FBgn0000014] seq_release:3 mol_weight=62410 cds_boundaries:(3R:12,635,430..12,653,744[-]) aa_length:590 transcript_info:[CG10325-RB seq_release:3] gene_info:[gene symbol:abd-A FBgn0000014 gene_boundaries: [hmr_yeast5_DM3-1_pombe.fasta]
  • CG10325-PB, isoform B [Drosophila melanogaster]gi|24647534|ref|NP_732176.1| CG10325-PB [Drosophila melanogaster]gi|1708230|sp|P29555|HMAA_DROME Homeobox protein abdominal-Agi|969083|gb|AAA84405.1| ABD-AII [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:complement(12635409..12635783,12635854..12636077,12648144..12648191,12651773..12652029,12652857..12653725); ID=FBpp0082829; name=abd-A-PB; parent=FBgn0000014,FBtr0083388; dbxref=FlyBase:FBpp0082829,FlyBase_Annotation_IDs:CG10325-PB,GB [fly-100309-contam.fasta]
  • ABD-AII [nr-271106-contam.fasta]
  • abdominal A CG10325-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG10325-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Homeobox protein abdominal-A [nr-271106-contam.fasta]
  • type=protein; loc=3R:complement(12635409..12635783,12635854..12636077,12648144..12648191,12651773..12652029,12652857..12653725); ID=FBpp0082829; name=abd-A-PB; parent=FBgn0000014,FBtr0083388; dbxref=FlyBase:FBpp0082829,FlyBase_Annotation_IDs:CG10325-PB,GB_protein:AAF55360.2,REFSEQ:NP_732176,GB_protein:AAF55360; MD5=e77705aa21130c372997ebddc452fc86; length=590; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(12635409..12635783,12635854..12636077,12648144..12648191,12651773..12652029,12652857..12653725); ID=FBpp0082829; name=abd-A-PB; parent=FBgn0000014,FBtr0083388; dbxref=FlyBase:FBpp0082829,FlyBase_Annotation_IDs:CG10325-PB,GB_protein:AAF55360.2,REFSEQ:NP_732176,GB_protein:AAF55360; MD5=e77705aa21130c372997ebddc452fc86; length=590; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=3R:complement(12635409..12635783,12635854..12636077,12648144..12648191,12651773..12652029,12652857..12653725); ID=FBpp0082829; name=abd-A-PB; parent=FBgn0000014,FBtr0083388; dbxref=FlyBase:FBpp0082829,FlyBase_Annotation_IDs:CG10325-PB,GB_protein:AAF55360.2,REFSEQ:NP_732176,GB_protein:AAF55360,FlyMine:FBpp0082829,modMine:FBpp0082829; MD5=e77705aa21130c372997ebddc452fc86; length=590; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:complement(join(16827135..16828003,16826051..16826307,16822422..16822469,16810132..16810355,16809687..16810061)); ID=FBpp0082829; name=abd-A-PB; parent=FBgn0000014,FBtr0083388; dbxref=FlyBase:FBpp0082829,FlyBase_Annotation_IDs:CG10325-PB,GB_protein:AAF55360.2,REFSEQ:NP_732176,GB_protein:AAF55360,FlyMine:FBpp0082829,modMine:FBpp0082829; MD5=e77705aa21130c372997ebddc452fc86; length=590; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:complement(join(16827135..16828003,16826051..16826307,16822422..16822469,16810132..16810355,16809687..16810061)); ID=FBpp0082829; name=abd-A-PB; parent=FBgn0000014,FBtr0083388; dbxref=FlyBase:FBpp0082829,FlyBase_Annotation_IDs:CG10325-PB,GB_protein:AAF55360.2,REFSEQ:NP_732176,GB_protein:AAF55360,FlyMine:FBpp0082829,modMine:FBpp0082829; MD5=e77705aa21130c372997ebddc452fc86; length=590; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0082829 type=protein; loc=3R:complement(join(16827135..16828003,16826051..16826307,16822422..16822469,16810132..16810355,16809687..16810061)); ID=FBpp0082829; name=abd-A-PB; parent=FBgn0000014,FBtr0083388; dbxref=FlyBase:FBpp0082829,FlyBase_Annotation_IDs:CG10325-PB,GB_protein:AAF55360.2,REFSEQ:NP_732176,GB_protein:AAF55360,FlyMine:FBpp0082829,modMine:FBpp0082829; MD5=e77705aa21130c372997ebddc452fc86; length=590; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:complement(join(16827135..16828003,16826051..16826307,16822422..16822469,16810132..16810355,16809687..16810061)); ID=FBpp0082829; name=abd-A-PB; parent=FBgn0000014,FBtr0083388; dbxref=FlyBase:FBpp0082829,FlyBase_Annotation_IDs:CG10325-PB,GB_protein:AAF55360.2,REFSEQ:NP_732176,GB_protein:AAF55360,UniProt/Swiss-Prot:P29555,FlyMine:FBpp0082829,modMine:FBpp0082829; MD5=e77705aa21130c372997ebddc452fc86; length=590; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 590 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA][NAS]
    Biological Process: midgut development [TAS]
    anterior/posterior pattern formation [IMP]
    nervous system development [IMP]
    positive regulation of muscle organ development [IMP]
    regulation of transcription [IEA]
    cardiac muscle tissue development [IMP]
    gonadal mesoderm development [IMP]
    heart development [IMP]
    apoptosis [IMP]
    positive regulation of gene-specific transcription from RNA polymerase II promoter [IMP]
    pole cell migration [TAS]
    genitalia development [IMP]
    specification of segmental identity, abdomen [NAS]
    dorsal vessel heart proper cell fate commitment [IEP][IMP][TAS]
    regulation of transcription, DNA-dependent [IEA][IMP]
    peripheral nervous system development [TAS]
    neuroblast fate determination [IMP]
    germ cell migration [IMP][TAS]
    cellular process [IMP]
    mesodermal cell fate specification [IMP]
    oenocyte development [IMP]
    gonad development [NAS][TAS]
    genital disc anterior/posterior pattern formation [IEP]
    cardioblast differentiation [IMP]
    determination of genital disc primordium [IMP]
    Molecular Function: transcription factor activity [IMP]
    specific RNA polymerase II transcription factor activity [NAS]
    RNA polymerase II transcription factor activity, enhancer binding [IDA]
    sequence-specific DNA binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKFVFDSML PKYPQFQPFI SSHHLTTTPP NSSSAAVAAA LAAAAASASA SVSASSSSNN  60
   61 NSSNTIAGSN TSNTNNSSSS PSSSSNNNSN LNLSGGSLSP SHLSQHLGQS PHSPVSSSSP 120
  121 FQQHHPQVQQ QHLNHQQQQH LHHQQQQHHH QYSSLSAALQ LQQQQHHISK LAAAAVASHG 180
  181 HAHQQLLLTP PSAGNSQAGD SSCSPSPSAS GSSSLHRSLN DNSPGSASAS ASASAASSVA 240
  241 AAAAAAAAAA SSSFAIPTSK MYPYVSNHPS SHGGLSGMAG FTGLEDKSCS RYTDTVMNSY 300
  301 QSMSVPASAS AQFAQFYQHA TAAASAVSAA SAGAIGVDSL GNACTQPASG VMPGAGGAGG 360
  361 AGIADLPRYP WMTLTDWMGS PFERVVCGDF NGPNGCPRRR GRQTYTRFQT LELEKEFHFN 420
  421 HYLTRRRRIE IAHALCLTER QIKIWFQNRR MKLKKELRAV KEINEQARRD REEQEKMKAQ 480
  481 ETMKSAQQNK QVQQQQQQQQ QQQQQQQQQH QQQQQQPQDH HSIIAHNPGH LHHSVVGQND 540
  541 LKLGLGMGVG VGVGGIGPGI GGGLGGNLGM MSALDKSNHD LLKAVSKVNS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..157] MSA 4.238995 View MSA. No confident structure predictions are available.
    2 View Details [158..293] MSA 2.253993 View MSA. No confident structure predictions are available.
    3 View Details [294..383] deduced N/A No confident structure predictions are available.
    4 View Details [384..488] PSI-BLAST 12.30103 Ultrabithorax (ubx) homeodomain
    5 View Details [489..590] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • transcription regulator activity
    		•  3.57523737355937 bayes_pls_golite062009
  • DNA binding
    		•  3.00143272905695 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.89825020286436 bayes_pls_golite062009
  • transcription factor activity
    		•  2.53664874743748 bayes_pls_golite062009
  • binding
    		•  1.68817361068715 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.46503550280898 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.24108783215685 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.20862059645422 bayes_pls_golite062009
  • protein binding
    		•  0.111941607625758 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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