Protein Overview: Kap-alpha3-PA, K...

General Information:
Name(s) found:	Kap-alpha3-PD / FBpp0290407 [FlyBase] Kap-alpha3-PC / FBpp0081586 [FlyBase] Kap-alpha3-PB / FBpp0081585 [FlyBase] Kap-alpha3-PA / FBpp0081584 [FlyBase]
Description(s) found: Found 59 descriptions. SHOW ALL	The gene karyopherin Ă?Ă?Âą3 is referred to in FlyBase by the symbol Dmel\Kap-Ă?Ă?Âą3 (CG9423, FBgn0027338). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:5400206..5403506. It has the cytological map location 85D25. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: positive regulation of NFAT protein import into nucleus. 13 alleles are reported. The phenotype of these alleles is annotated with: tergite. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase] The gene karyopherin Ă?Ă?Âą3 is referred to in FlyBase by the symbol Dmel\Kap-Ă?Ă?Âą3 (CG9423, FBgn0027338). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:5400206..5403506. It has the cytological map location 85D25. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: positive regulation of NFAT protein import into nucleus. 13 alleles are reported. The phenotype of these alleles is annotated with: tergite. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase] The gene karyopherin Ă?Ă?Âą3 is referred to in FlyBase by the symbol Dmel\Kap-Ă?Ă?Âą3 (CG9423, FBgn0027338). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:5400206..5403506. It has the cytological map location 85D25. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: positive regulation of NFAT protein import into nucleus. 13 alleles are reported. The phenotype of these alleles is annotated with: tergite. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase] The gene karyopherin Ă?Ă?Âą3 is referred to in FlyBase by the symbol Dmel\Kap-Ă?Ă?Âą3 (CG9423, FBgn0027338). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:5400206..5403506. It has the cytological map location 85D25. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: positive regulation of NFAT protein import into nucleus. 13 alleles are reported. The phenotype of these alleles is annotated with: tergite. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	514 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IEA] nuclear pore [ISS][NAS]
Biological Process:	positive regulation of NFAT protein import into nucleus [IMP] protein import into nucleus [ISS][NAS] response to UV [IDA]
Molecular Function:	protein binding [IPI] protein transmembrane transporter activity [NAS] protein transporter activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSMEQNRLQ NFKNKGKDQD EMRRRRNEVT VELRKNKREE TILKRRNVPN LDSNTDEEEQ  60
   61 LSSSIDLKKL AKAAADATKP EQQLAAVQAA RKLLSSDKNP PINDLIQSDI LPILVECLKQ 120
  121 HNHTMLQFEA AWALTNIASG TSAQTNEVVA AGAVPLFLQL LNSPAPNVCE QAVWALGNII 180
  181 GDGPLLRDFV IKHGVVQPLL SFIKPDIPIT FLRNVTWVIV NLCRNKDPAP PTATIHEILP 240
  241 ALNVLIHHTD TNILVDTVWA ISYLTDGGND QIQMVIESGV VPKLIPLLGN SEVKVQTAAL 300
  301 RAVGNIVTGS DEQTQVVLNY DALSYFPGLL SHPKEKIRKE AVWFLSNITA GNQSQVQAVI 360
  361 NVGLLPKIIE NLSKGEFQTQ KEAAWAISNL TISGNREQVF TLIKEGVIPP FCDLLSCQDT 420
  421 QVINVVLDGL NNMLKVADSH VEAVANCIEE CEGLAKIERL QSHENVEIYK LAYEIIDQYF 480
  481 TDEGEQTNMA PTSDGAQYNF DPHADRLTMN SFNF

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

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Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
protein transporter activity	4.58709163830613	bayes_pls_golite062009
nuclear export signal receptor activity	3.48172991171337	bayes_pls_golite062009
binding	3.0667965351474	bayes_pls_golite062009
actin binding	2.8014924948341	bayes_pls_golite062009
nucleic acid binding	2.74745843355294	bayes_pls_golite062009
protein transmembrane transporter activity	2.74547353635661	bayes_pls_golite062009
cytoskeletal protein binding	2.61566088685247	bayes_pls_golite062009
transporter activity	2.48700774379895	bayes_pls_golite062009
substrate-specific transporter activity	2.26725422172281	bayes_pls_golite062009
transcription regulator activity	2.16673352512615	bayes_pls_golite062009
DNA binding	1.95242774903625	bayes_pls_golite062009
nuclear localization sequence binding	1.91487015967262	bayes_pls_golite062009
protein binding	1.73688475473996	bayes_pls_golite062009
molecular transducer activity	1.32874350341969	bayes_pls_golite062009
signal transducer activity	1.32874350341969	bayes_pls_golite062009
transmembrane transporter activity	1.28481004323799	bayes_pls_golite062009
transcription factor activity	1.20660383756339	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.09652988954158	bayes_pls_golite062009
signal sequence binding	0.57106697498903	bayes_pls_golite062009
RNA binding	0.40024158562931	bayes_pls_golite062009
structural molecule activity	0.279926218252647	bayes_pls_golite062009
importin-alpha export receptor activity	0.259676026705859	bayes_pls_golite062009
active transmembrane transporter activity	0.252495966234234	bayes_pls_golite062009
ion transmembrane transporter activity	0.248585912061178	bayes_pls_golite062009
primary active transmembrane transporter activity	0.226380819487924	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.217517113570989	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.178770060806735	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.175241020572885	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.174922130116569	bayes_pls_golite062009
transcription activator activity	0.160275383613705	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.100181463251306	bayes_pls_golite062009
pyrophosphatase activity	0.0635404099346928	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0548082069333885	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.052195223119721	bayes_pls_golite062009
cation transmembrane transporter activity	0.0405268469927988	bayes_pls_golite062009
transcription factor binding	0.0221966060394205	bayes_pls_golite062009

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..514]	PSI-BLAST	98.0	Crystal structure of the exportin Cse1p complexed with its cargo ( Kap60p) and RanGTP

Protein Overview: Kap-alpha3-PA, K...

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: