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Protein Overview: Rel-PB, Rel-PC, ...

General Information:
Name(s) found: Rel-PB / FBpp0088973 [FlyBase]
Rel-PC / FBpp0088971 [FlyBase]
Rel-PA / FBpp0088375 [FlyBase]
Description(s) found:
Found 52 descriptions.
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  • The gene Relish is referred to in FlyBase by the symbol Dmel\Rel (CG11992, FBgn0014018). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:4869900..4873699. It has the cytological map location 85C3. There is experimental evidence that it has the molecular function</span>: protein binding; sequence-specific DNA binding; transcription activator activity; DNA binding. There is experimental evidence for 12 unique biological process</span> terms, many of which group under: positive regulation of cellular biosynthetic process; regulation of metabolic process; regulation of immune system process; immune response; defense response; response to stress; response to nutrient levels; positive regulation of response to stimulus; regulation of antimicrobial peptide production; positive regulation of macromolecule metabolic process. 48 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • The gene Relish is referred to in FlyBase by the symbol Dmel\Rel (CG11992, FBgn0014018). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:4869900..4873699. It has the cytological map location 85C3. There is experimental evidence that it has the molecular function</span>: protein binding; sequence-specific DNA binding; transcription activator activity; DNA binding. There is experimental evidence for 12 unique biological process</span> terms, many of which group under: positive regulation of cellular biosynthetic process; regulation of metabolic process; regulation of immune system process; immune response; defense response; response to stress; response to nutrient levels; positive regulation of response to stimulus; regulation of antimicrobial peptide production; positive regulation of macromolecule metabolic process. 48 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • The gene Relish is referred to in FlyBase by the symbol Dmel\Rel (CG11992, FBgn0014018). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:4869900..4873699. It has the cytological map location 85C3. There is experimental evidence that it has the molecular function</span>: protein binding; sequence-specific DNA binding; transcription activator activity; DNA binding. There is experimental evidence for 12 unique biological process</span> terms, many of which group under: positive regulation of cellular biosynthetic process; regulation of metabolic process; regulation of immune system process; immune response; defense response; response to stress; response to nutrient levels; positive regulation of response to stimulus; regulation of antimicrobial peptide production; positive regulation of macromolecule metabolic process. 48 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 971 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    cytoplasm [IDA]
    Biological Process: Toll signaling pathway [TAS]
    positive regulation of nitric oxide biosynthetic process [IMP]
    defense response to Gram-negative bacterium [IMP][TAS]
    signal transduction [TAS]
    cellular response to amino acid starvation [IMP]
    regulation of transcription, DNA-dependent [IEA]
    positive regulation of antibacterial peptide biosynthetic process [IEP][IMP][NAS][TAS]
    regulation of transcription [IEA]
    positive regulation of transcription from RNA polymerase II promoter [TAS]
    positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria [IMP]
    positive regulation of antifungal peptide biosynthetic process [IMP]
    response to bacterium [TAS]
    immune response [IEP][IMP][TAS]
    positive regulation of innate immune response [IMP]
    innate immune response [IDA][NAS]
    positive regulation of gene expression [IMP]
    antimicrobial humoral response [IMP]
    positive regulation of gene-specific transcription from RNA polymerase II promoter [IDA]
    Molecular Function: DNA binding [IDA]
    transcription factor activity [IEA][NAS][TAS]
    protein binding [IPI]
    sequence-specific DNA binding [IDA]
    transcription activator activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMNQYYDLD NGKNVMFMND ASSTSGYSSS TSPNSTNRSF SPAHSPKTME LQTDFANLNL  60
   61 PGGNSPHQPP MANSPYQNQL LNNGGICQLG ATNLINSTGV SFGVANVTSF GNMYMDHQYF 120
  121 VPAPATVPPS QNFGYHQNGL ASDGDIKHVP QLRIVEQPVE KFRFRYKSEM HGTHGSLNGA 180
  181 NSKRTPKTFP EVTLCNYDGP AVIRCSLFQT NLDSPHSHQL VVRKDDRDVC DPHDLHVSKE 240
  241 RGYVAQFINM GIIHTAKKYI FEELCKKKQD RLVFQMNRRE LSHKQLQELH QETEREAKDM 300
  301 NLNQVRLCFE AFKIEDNGAW VPLAPPVYSN AINNRKSAQT GELRIVRLSK PTGGVMGNDE 360
  361 LILLVEKVSK KNIKVRFFEE DEDGETVWEA YAKFRESDVH HQYAIVCQTP PYKDKDVDRE 420
  421 VNVYIELIRP SDDERSFPAL PFRYKPRSVI VSRKRRRTGS SANSSSSGTE SSNNSLDLPK 480
  481 TLGLAQPPNG LPNLSQHDQT ISEEFGREKH LNEFIASEDF RKLIEHNSSD LEKICQLDMG 540
  541 ELQHDGHNRA EVPSHRNRTI KCLDDLFEIY KQDRISPIKI SHHKVEKWFI EHALNNYNRD 600
  601 TLLHEVISHK KDKLKLAIQT IQVMNYFNLK DVVNSTLNAD GDSALHVACQ QDRAHYIRPL 660
  661 LGMGCNPNLK NNAGNTPLHV AVKEEHLSCV ESFLNGVPTV QLDLSLTNDD GLTPLHMAIR 720
  721 QNKYDVAKKL ISYDRTSISV ANTMDGNNAL HMAVLEQSVE LLVLILDAQN ENLTDILQAQ 780
  781 NAAGHTPLEL AERKANDRVV QLLKNVYPEK GELAMTWIPC KVKEEIDSSS DESSDAGQLE 840
  841 IKSEEMDIET KDEDSVELDL SSGPRRQKDE SSRDTEMDNN KLQLLLKNKF IYDRLCSLLN 900
  901 QPLGHGSDPQ DRKWMQLARQ THLKQFAFIW LGAEDLLDHV KRKGASVEFS TFARALQAVD 960
  961 PQAYALLVNP T

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..93] deduced N/A No confident structure predictions are available.
    2 View Details [94..456] PSI-BLAST 108.0 p50 subunit of NF-kappa B transcription factor; p50 subunit of NF-kappa B (NFKB), N-terminal domain
    3 View Details [457..543] deduced N/A No confident structure predictions are available.
    4 View Details [544..611] PSI-BLAST 9.69897 Swi6 ankyrin-repeat fragment
    5 View Details [612..971] PSI-BLAST 83.045757 Ankyrin-R

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  5.42929256050781 bayes_pls_golite062009
  • DNA binding
    		•  5.31133900263778 bayes_pls_golite062009
  • nucleic acid binding
    		•  5.16722510757739 bayes_pls_golite062009
  • transcription factor activity
    		•  4.50526425463039 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.91938513552138 bayes_pls_golite062009
  • transcription activator activity
    		•  3.89749713667575 bayes_pls_golite062009
  • binding
    		•  3.82913410895101 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.14317875446423 bayes_pls_golite062009
  • protein binding
    		•  2.61625563263605 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.87544096847314 bayes_pls_golite062009
  • DNA strand annealing activity
    		•  1.81456840545282 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.68237504321416 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  1.49080128448961 bayes_pls_golite062009
  • chromatin binding
    		•  1.28001279726096 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.27337392672914 bayes_pls_golite062009
  • transcription factor binding
    		•  0.628837188707778 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.35905469882415 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.0889583851427092 bayes_pls_golite062009
  • chitin binding
    		•  0.0880651619819113 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  0.0676214219421661 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  0.0676214219421661 bayes_pls_golite062009
  • cation channel activity
    		•  0.0318083563912285 bayes_pls_golite062009
    3
    Term Confidence Notes
  • protein binding
    		•  2.69918165732603 bayes_pls_golite062009
  • binding
    		•  2.60916417202222 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.37103377984038 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.8957142857582 bayes_pls_golite062009
  • DNA binding
    		•  1.78305438715057 bayes_pls_golite062009
  • transcription activator activity
    		•  1.6418915400902 bayes_pls_golite062009
  • transcription factor activity
    		•  1.2667825651547 bayes_pls_golite062009
  • transcription factor binding
    		•  1.06366405671195 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.949906091645366 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.590503097160372 bayes_pls_golite062009
    4 No functions predicted.
    5
    Term Confidence Notes
  • protein binding
    		•  2.69918165732603 bayes_pls_golite062009
  • binding
    		•  2.60916417202222 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.37103377984038 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.8957142857582 bayes_pls_golite062009
  • DNA binding
    		•  1.78305438715057 bayes_pls_golite062009
  • transcription activator activity
    		•  1.6418915400902 bayes_pls_golite062009
  • transcription factor activity
    		•  1.2667825651547 bayes_pls_golite062009
  • transcription factor binding
    		•  1.06366405671195 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.949906091645366 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.590503097160372 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle