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Protein Overview: cas-PA

General Information:
Name(s) found: cas-PA / FBpp0078374 [FlyBase]
Description(s) found:
Found 24 descriptions.
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  • The gene castor is referred to in FlyBase by the symbol Dmel\cas (CG2102, FBgn0004878). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:1538664..1543022. It has the cytological map location 83C1. There is experimental evidence that it has the molecular function</span>: DNA binding. There is experimental evidence that it is involved in the biological process</span>: central nervous system development; mushroom body development; post-embryonic development; negative regulation of transcription, DNA-dependent. 28 alleles are reported. The phenotypes of these alleles are annotated with: mushroom body; mushroom body beta'-lobe; U5 neuron; eye; U4 neuron; neuroblast; posterior commissure; macrochaeta; mushroom body beta-lobe; embryonic central nervous system. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 793 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][NAS]
    Biological Process: ventral cord development [NAS]
    central nervous system development [IMP]
    negative regulation of transcription, DNA-dependent [IMP]
    mushroom body development [IGI][IMP]
    regulation of development, heterochronic [NAS]
    post-embryonic development [IMP]
    regulation of transcription, DNA-dependent [NAS]
    regulation of transcription from RNA polymerase II promoter [NAS]
    ganglion mother cell fate determination [TAS]
    Molecular Function: DNA binding [IDA]
    transcription factor activity [NAS]
    zinc ion binding [IEA]
    RNA polymerase II transcription factor activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNQMEFIMQ LYMMNLMKQQ QQMQLQLPQQ QQQQQLAGYT YTQNEDISSS TSVQQQQQQQ  60
   61 QEQLQQPQPD LRKTRTHKRI SSQNTNCSSS RSCSPNSNLI AFQPQQYPGA TAATPSTPNS 120
  121 HPSNLVNQML LQSLPPLTQL MLQQQQQQHL LTTSNLLLTP THTPSSLGKQ DPLQHPLLLG 180
  181 QFAGSEQMAT NNFLQSSTVT STPIEREKAA TPAPSAGATA GNLSAAQVKF EQESADDDED 240
  241 DDKPLSSLTS CSSSGHTNAS SEKLLLSGVH PLESTTDSLD SPSMYTPVKQ PADSSYGLIT 300
  301 PVDSDLTPNT PLQPTQTISL LTPPSSEQSK SLVSLSAASG LDALLQNEEV LKNLRKVSSY 360
  361 LECENSLCRQ ENLREHFHCH EEPCQGKILS KKDDIIRHLK WHKKRKESLK LGFARFSSSD 420
  421 DCAPAYGEGC AYNWKQTHYH CVYEHCPKVY VSTSDVQMHA NFHRKDSEIV NEGFRRFRAH 480
  481 ETCRIEDCPF FGKKISHYHC CREGCTHTFK NKADMDKHKT YHLKDHQLKM DGFKKILKTE 540
  541 VCPFDACKFS TVCNHIHCVR EGCDYILHSS SQMISHKRKH DRQDGEQAYQ QFKIKQDVEE 600
  601 SSLDAMPQQQ QQQQQQQPTS LSQSQSSSSV CGGSNTSTPL SSLSAEHFLA RKRGRPPKKI 660
  661 QLPADAQQSE AKRLKVEDES SNPAMLLPQS QPAAAVHPLT SGLFPGLLPA AAAPGVDPTA 720
  721 PNFQLTHLMA LFQLQNPLFY QNLYPGMTQN SSMLGNLAAL SAASAAAAAA AAANGAGVQQ 780
  781 PKAEFSFKPE FKE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..235] MSA 2.222989 View MSA. No confident structure predictions are available.
    2 View Details [236..284] deduced N/A No confident structure predictions are available.
    3 View Details [285..389] PSI-BLAST 18.522879 Designed zinc finger protein
    4 View Details [390..491] PSI-BLAST 26.69897 Transcription factor IIIA, TFIIIA
    5 View Details [492..707] PSI-BLAST 50.522879 No description for 2i13A was found.
    6 View Details [708..793] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • transcription regulator activity
    		•  4.70988788192472 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.58713908116892 bayes_pls_golite062009
  • DNA binding
    		•  4.56219307357342 bayes_pls_golite062009
  • transcription factor activity
    		•  3.50954949535763 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.27542149084008 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.22082323675675 bayes_pls_golite062009
  • binding
    		•  3.10743787485868 bayes_pls_golite062009
  • transcription activator activity
    		•  2.19952417915035 bayes_pls_golite062009
  • chromatin binding
    		•  2.18464662431232 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.63161912031789 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.42975942698743 bayes_pls_golite062009
  • transcription factor binding
    		•  1.39608963544799 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.34049786451995 bayes_pls_golite062009
  • protein binding
    		•  1.00484935878505 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.77874411480713 bayes_pls_golite062009
  • catalytic activity
    		•  0.245893663605433 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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