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View Structure Prediction Details

Protein: cas-PA
Organism: Drosophila melanogaster
Length: 793 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cas-PA.

Description E-value Query
Range
Subject
Range
gi|73970462 - gi|73970462|ref|XP_531880.2| PREDICTED: similar to Zinc finger protein 208 [Canis familiaris]
600.0 [0..142] [707..368]

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Predicted Domain #1
Region A:
Residues: [1-235]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNQMEFIMQ LYMMNLMKQQ QQMQLQLPQQ QQQQQLAGYT YTQNEDISSS TSVQQQQQQQ  60
   61 QEQLQQPQPD LRKTRTHKRI SSQNTNCSSS RSCSPNSNLI AFQPQQYPGA TAATPSTPNS 120
  121 HPSNLVNQML LQSLPPLTQL MLQQQQQQHL LTTSNLLLTP THTPSSLGKQ DPLQHPLLLG 180
  181 QFAGSEQMAT NNFLQSSTVT STPIEREKAA TPAPSAGATA GNLSAAQVKF EQESA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [236-284]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDDEDDDKPL SSLTSCSSSG HTNASSEKLL LSGVHPLEST TDSLDSPSM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [285-389]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YTPVKQPADS SYGLITPVDS DLTPNTPLQP TQTISLLTPP SSEQSKSLVS LSAASGLDAL  60
   61 LQNEEVLKNL RKVSSYLECE NSLCRQENLR EHFHCHEEPC QGKIL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.522879
Match: 1meyC
Description: Designed zinc finger protein
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [390-491]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKKDDIIRHL KWHKKRKESL KLGFARFSSS DDCAPAYGEG CAYNWKQTHY HCVYEHCPKV  60
   61 YVSTSDVQMH ANFHRKDSEI VNEGFRRFRA HETCRIEDCP FF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.69897
Match: 1tf6A
Description: Transcription factor IIIA, TFIIIA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
transcription repressor activity 3.27542149084008 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
sequence-specific DNA binding 1.42975942698743 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
transcription corepressor activity 1.34049786451995 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [492-707]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKKISHYHCC REGCTHTFKN KADMDKHKTY HLKDHQLKMD GFKKILKTEV CPFDACKFST  60
   61 VCNHIHCVRE GCDYILHSSS QMISHKRKHD RQDGEQAYQQ FKIKQDVEES SLDAMPQQQQ 120
  121 QQQQQQPTSL SQSQSSSSVC GGSNTSTPLS SLSAEHFLAR KRGRPPKKIQ LPADAQQSEA 180
  181 KRLKVEDESS NPAMLLPQSQ PAAAVHPLTS GLFPGL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.522879
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #6
Region A:
Residues: [708-793]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPAAAAPGVD PTAPNFQLTH LMALFQLQNP LFYQNLYPGM TQNSSMLGNL AALSAASAAA  60
   61 AAAAAANGAG VQQPKAEFSF KPEFKE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle