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Protein Overview: CG12163-PA

General Information:
Name(s) found: CG12163-PA / FBpp0078465 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG12163 (CG12163, FBgn0260462). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:1063223..1077468. It has the cytological map location 82F6-82F7. Based on sequence similarity, it is predicted to have molecular function</span>: cysteine-type endopeptidase activity. There is experimental evidence that it is involved in the biological process</span>: autophagic cell death; salivary gland cell autophagic cell death. 10 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 614 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: autophagic cell death [IEP]
    proteolysis [ISS]
    salivary gland cell autophagic cell death [IEP]
    Molecular Function: cysteine-type endopeptidase inhibitor activity [IEA]
    cysteine-type endopeptidase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLFAAATVA LVLLLGQAAG EELAEERAGQ AQGDAESTES SETTTDQAVS EPPITLVHVL  60
   61 NPGEREYLSP NLIGVQNIAM TFLPLSMNFV NIIDAFREIT AGVRYEILLN ALDTKAIQPA 120
  121 EADIVCRLVI LEKPWLRTQW GDKHRELVTS NCTDPAVNSV AGDPAEKARL LNEKYVHRSR 180
  181 RSANDILGRH KPYDEEAAKA QLQKSLDKLT AGEGPHYKIV KVYSASRQVD SGILTRIDAD 240
  241 LIDGSEEQHR CIVDIWTKVW VRKDEHEITF KCRNQPVVQA RHTRSVEWAE KKTHKKHSHR 300
  301 FDKVDHLFYK FQVRFGRRYV STAERQMRLR IFRQNLKTIE ELNANEMGSA KYGITEFADM 360
  361 TSSEYKERTG LWQRDEAKAT GGSAAVVPAY HGELPKEFDW RQKDAVTQVK NQGSCGSCWA 420
  421 FSVTGNIEGL YAVKTGELKE FSEQELLDCD TTDSACNGGL MDNAYKAIKD IGGLEYEAEY 480
  481 PYKAKKNQCH FNRTLSHVQV AGFVDLPKGN ETAMQEWLLA NGPISIGINA NAMQFYRGGV 540
  541 SHPWKALCSK KNLDHGVLVV GYGVSDYPNF HKTLPYWIVK NSWGPRWGEQ GYYRVYRGDN 600
  601 TCGVSEMATS AVLA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..150] PSI-BLAST 26.09691 Phytocystatin
    2 View Details [151..293] PSI-BLAST 4.154902 Cystatin A (stefin A)
    3 View Details [294..614] PSI-BLAST 83.69897 (Pro)cathepsin K

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protease binding
    		•  2.33924947399883 bayes_pls_golite062009
  • endopeptidase inhibitor activity
    		•  2.281153350492 bayes_pls_golite062009
  • peptidase inhibitor activity
    		•  2.2751983744098 bayes_pls_golite062009
  • cysteine-type endopeptidase inhibitor activity
    		•  1.5023849476868 bayes_pls_golite062009
  • binding
    		•  1.35239730089344 bayes_pls_golite062009
  • enzyme inhibitor activity
    		•  1.2246857430038 bayes_pls_golite062009
  • protein binding
    		•  0.723461675092055 bayes_pls_golite062009
  • structural molecule activity
    		•  0.410373379064067 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.364835684922551 bayes_pls_golite062009
  • enzyme binding
    		•  0.2069873067106 bayes_pls_golite062009
    2
    Term Confidence Notes
  • protease binding
    		•  2.33924947399883 bayes_pls_golite062009
  • endopeptidase inhibitor activity
    		•  2.281153350492 bayes_pls_golite062009
  • peptidase inhibitor activity
    		•  2.2751983744098 bayes_pls_golite062009
  • cysteine-type endopeptidase inhibitor activity
    		•  1.5023849476868 bayes_pls_golite062009
  • binding
    		•  1.35239730089344 bayes_pls_golite062009
  • enzyme inhibitor activity
    		•  1.2246857430038 bayes_pls_golite062009
  • protein binding
    		•  0.723461675092055 bayes_pls_golite062009
  • structural molecule activity
    		•  0.410373379064067 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.364835684922551 bayes_pls_golite062009
  • enzyme binding
    		•  0.2069873067106 bayes_pls_golite062009
    3
    Term Confidence Notes
  • peptidase activity
    		•  4.90619850296986 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  4.64381885397949 bayes_pls_golite062009
  • endopeptidase activity
    		•  3.75054525912786 bayes_pls_golite062009
  • hydrolase activity
    		•  3.74079711298952 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  2.71117522993364 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  1.95802900199539 bayes_pls_golite062009
  • binding
    		•  1.29265216891074 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.12653729823589 bayes_pls_golite062009
  • catalytic activity
    		•  1.05972260874031 bayes_pls_golite062009
  • protein binding
    		•  0.774177093888744 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  0.649171767629235 bayes_pls_golite062009
  • thiolester hydrolase activity
    		•  0.59115205419466 bayes_pls_golite062009
  • kininogen binding
    		•  0.41283715939055 bayes_pls_golite062009
  • signal transducer activity
    		•  0.12644030784065 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.12644030784065 bayes_pls_golite062009
  • structural molecule activity
    		•  0.102555314244558 bayes_pls_golite062009
  • tubulin binding
    		•  0.0482209771629902 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  0.0101379718864654 bayes_pls_golite062009
  • microtubule binding
    		•  0.00635493133568055 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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