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View Structure Prediction Details

Protein: CG12163-PA
Organism: Drosophila melanogaster
Length: 614 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG12163-PA.

Description E-value Query
Range
Subject
Range
gi|116129390, gi... - gi|118782057|ref|XP_312034.3| ENSANGP00000018713 [Anopheles gambiae str. PEST], gi|116129390|gb|EAA0...
436.0 [0..50] [614..1]

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Predicted Domain #1
Region A:
Residues: [1-150]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLFAAATVA LVLLLGQAAG EELAEERAGQ AQGDAESTES SETTTDQAVS EPPITLVHVL  60
   61 NPGEREYLSP NLIGVQNIAM TFLPLSMNFV NIIDAFREIT AGVRYEILLN ALDTKAIQPA 120
  121 EADIVCRLVI LEKPWLRTQW GDKHRELVTS 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.09691
Match: 1eqkA
Description: Phytocystatin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protease binding 2.33924947399883 bayes_pls_golite062009
endopeptidase inhibitor activity 2.281153350492 bayes_pls_golite062009
peptidase inhibitor activity 2.2751983744098 bayes_pls_golite062009
cysteine-type endopeptidase inhibitor activity 1.5023849476868 bayes_pls_golite062009
binding 1.35239730089344 bayes_pls_golite062009
enzyme inhibitor activity 1.2246857430038 bayes_pls_golite062009
protein binding 0.723461675092055 bayes_pls_golite062009
structural molecule activity 0.410373379064067 bayes_pls_golite062009
enzyme regulator activity 0.364835684922551 bayes_pls_golite062009
enzyme binding 0.2069873067106 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [151-293]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NCTDPAVNSV AGDPAEKARL LNEKYVHRSR RSANDILGRH KPYDEEAAKA QLQKSLDKLT  60
   61 AGEGPHYKIV KVYSASRQVD SGILTRIDAD LIDGSEEQHR CIVDIWTKVW VRKDEHEITF 120
  121 KCRNQPVVQA RHTRSVEWAE KKT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.154902
Match: 1gd4A
Description: Cystatin A (stefin A)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protease binding 2.33924947399883 bayes_pls_golite062009
endopeptidase inhibitor activity 2.281153350492 bayes_pls_golite062009
peptidase inhibitor activity 2.2751983744098 bayes_pls_golite062009
cysteine-type endopeptidase inhibitor activity 1.5023849476868 bayes_pls_golite062009
binding 1.35239730089344 bayes_pls_golite062009
enzyme inhibitor activity 1.2246857430038 bayes_pls_golite062009
protein binding 0.723461675092055 bayes_pls_golite062009
structural molecule activity 0.410373379064067 bayes_pls_golite062009
enzyme regulator activity 0.364835684922551 bayes_pls_golite062009
enzyme binding 0.2069873067106 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [294-614]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HKKHSHRFDK VDHLFYKFQV RFGRRYVSTA ERQMRLRIFR QNLKTIEELN ANEMGSAKYG  60
   61 ITEFADMTSS EYKERTGLWQ RDEAKATGGS AAVVPAYHGE LPKEFDWRQK DAVTQVKNQG 120
  121 SCGSCWAFSV TGNIEGLYAV KTGELKEFSE QELLDCDTTD SACNGGLMDN AYKAIKDIGG 180
  181 LEYEAEYPYK AKKNQCHFNR TLSHVQVAGF VDLPKGNETA MQEWLLANGP ISIGINANAM 240
  241 QFYRGGVSHP WKALCSKKNL DHGVLVVGYG VSDYPNFHKT LPYWIVKNSW GPRWGEQGYY 300
  301 RVYRGDNTCG VSEMATSAVL A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 83.69897
Match: 1by8A
Description: (Pro)cathepsin K
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 4.90619850296986 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 4.64381885397949 bayes_pls_golite062009
endopeptidase activity 3.75054525912786 bayes_pls_golite062009
hydrolase activity 3.74079711298952 bayes_pls_golite062009
cysteine-type peptidase activity 2.71117522993364 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.95802900199539 bayes_pls_golite062009
binding 1.29265216891074 bayes_pls_golite062009
cytoskeletal protein binding 1.12653729823589 bayes_pls_golite062009
catalytic activity 1.05972260874031 bayes_pls_golite062009
protein binding 0.774177093888744 bayes_pls_golite062009
small conjugating protein-specific protease activity 0.649171767629235 bayes_pls_golite062009
thiolester hydrolase activity 0.59115205419466 bayes_pls_golite062009
kininogen binding 0.41283715939055 bayes_pls_golite062009
signal transducer activity 0.12644030784065 bayes_pls_golite062009
molecular transducer activity 0.12644030784065 bayes_pls_golite062009
structural molecule activity 0.102555314244558 bayes_pls_golite062009
tubulin binding 0.0482209771629902 bayes_pls_golite062009
ubiquitin-specific protease activity 0.0101379718864654 bayes_pls_golite062009
microtubule binding 0.00635493133568055 bayes_pls_golite062009

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