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Protein Overview: Gnf1-PA

General Information:
Name(s) found: Gnf1-PA / FBpp0078478 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene Germ line transcription factor 1 is referred to in FlyBase by the symbol Dmel\Gnf1 (CG1119, FBgn0004913). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:732348..735803. It has the cytological map location 82E2. There is experimental evidence that it has the molecular function</span>: DNA binding. It is reported to be involved in the biological process</span>: DNA replication. 6 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 986 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][NAS]
    DNA replication factor C complex [IEA][NAS]
    Biological Process: DNA replication [IEA][NAS]
    Molecular Function: DNA binding [IDA][NAS]
    ATP binding [IEA]
    DNA clamp loader activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQRGIDSFFK RLPAKAKSAE AENGETPSKA PKRRKAVIIS SDEDEVVSPP ETKKRKASKT  60
   61 ASSEDDVVAA TPEPIAKKAR NGQKPALSKL KRHVDPTELF GGETKRVIVP KPKTKAVLEF 120
  121 ENEDIDRSLM EVDLDESIKE AAPEKKVHSI TRSSPSPKRA KNSSPEPPKP KSTKSKATTP 180
  181 RVKKEKPAAD LESSVLTDEE RHERKRASAV LYQKYKNRSS CLNPGSKEIP KGSPDCLSGL 240
  241 TFVVTGVLES MEREEAESVI KEYGGKVMTV VGKKLKYLVV GEEAGPKKLA VAEELNIPIL 300
  301 SEDGLFDLIR EKSGIAKQVK EEKKSPKKEH SSEEKGKKEV KTSRRSSDKK EKEATKLKYG 360
  361 EKHDIAKHKV KEEHTSPKET KDKLNDVPAV TLKVKKEPSS QKEHPPSPRT ADLKTLDVVG 420
  421 MAWVDKHKPT SIKEIVGQAG AASNVTKLMN WLSKWYVNHD GNKKPQRPNP WAKNDDGSFY 480
  481 KAALLSGPPG IGKTTTATLV VKELGFDAVE FNASDTRSKR LLKDEVSTLL SNKSLSGYFT 540
  541 GQGQAVSRKH VLIMDEVDGM AGNEDRGGMQ ELIALIKDSS IPIICMCNDR NHPKIRSLVN 600
  601 YCYDLRFQRP RLEQIKGKIM SICFKEKVKI SPAKVEEIIA ATNNDIRQSI NHIALLSAKE 660
  661 DASQKSGQQV ATKDLKLGPW EVVRKVFTAD EHKHMSFADK SDLFFHDYSL APLFVQQNYL 720
  721 QVLPQGNKKD VLAKVAATAD ALSLGDLVEK RIRANSAWSL LPTQAFFSSV LPGEHMCGHF 780
  781 TGQINFPGWL GKNSKSGKRA RLAQELHDHT RVCTSGSRLS VRLDYAPFLL DNIVRPLAKD 840
  841 GQEGVPAALD VMKDYHLLRE DLDSLVELTS WPGKKSPLDA VDGRVKAALT RSYNKEVMAY 900
  901 SYSAQAGIKK KKSEAAGADD DYLDEGPGEE DGAGGHLSSE EDEDKDNLEL DSLIKAKKRT 960
  961 TTSKASGGSK KATSSTASKS KAKAKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..125] MSA 1.163993 View MSA. No confident structure predictions are available.
    2 View Details [126..224] PSI-BLAST 14.0 Crystal structure of N-terminal domain of E.Coli Lon Protease
    3 View Details [225..402] PSI-BLAST 22.045757 Crystal Structure Analysis of ClpB
    4 View Details [403..907] PSI-BLAST 54.69897 Crystal Structure of the Eukaryotic Clamp Loader (Replication Factor C, RFC) Bound to the DNA Sliding Clamp (Proliferating Cell Nuclear Antigen, PCNA)
    5 View Details [908..986] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  1.16354923842292 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.15712369152434 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.01821010146225 bayes_pls_golite062009
  • DNA binding
    		•  0.851165739361333 bayes_pls_golite062009
  • transcription factor activity
    		•  0.219534193320134 bayes_pls_golite062009
  • catalytic activity
    		•  0.147263815852997 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • DNA clamp loader activity
    		•  5.5471162885167 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  5.51408792884858 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  2.72462789867829 bayes_pls_golite062009
  • DNA helicase activity
    		•  2.2817164193758 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.13284212711072 bayes_pls_golite062009
  • binding
    		•  2.05253348982328 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  1.88455339138556 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.49633029954726 bayes_pls_golite062009
  • helicase activity
    		•  1.16085745407703 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  0.971476020912368 bayes_pls_golite062009
  • DNA binding
    		•  0.967303417236485 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.928091843881235 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.748437190903548 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.59513742813869 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.59513742813869 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.249173645231486 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.147579541298736 bayes_pls_golite062009
  • nucleotide binding
    		•  0.114848452385726 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.113504049290503 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.111293884322157 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.10713474095071 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0916519414118148 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0915913646217636 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.089234257580272 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.0781650226500197 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle