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Protein Overview: Rpn12-PA

General Information:
Name(s) found: Rpn12-PA / FBpp0075068 [FlyBase]
Description(s) found:
Found 24 descriptions.
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  • The gene Rpn12 is referred to in FlyBase by the symbol Dmel\Rpn12 (CG4157, FBgn0028693). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:16576083..16577122. It has the cytological map location 73A10. There is experimental evidence that it has the molecular function</span>: endopeptidase activity. There is experimental evidence that it is involved in the biological process</span>: mitotic spindle elongation; cell proliferation; cellular process; mitotic spindle organization; proteolysis. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 264 amino acids

    Gene Ontology:
    Cellular Component: proteasome regulatory particle [IDA][ISS]
    proteasome regulatory particle, lid subcomplex [ISS][NAS]
    Biological Process: cell proliferation [IMP]
    mitotic spindle elongation [IMP]
    mitotic spindle organization [IMP]
    proteolysis [IDA][ISS]
    cellular process [IMP]
    Molecular Function: endopeptidase activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANVESLYKE LTAEWSKRPP NTVKCGQLLD QLKVALVKMA FLPTDGNDAQ SSKKQLILAR  60
   61 SVLEVAVEHS VLSKDLLAFE RYMAQLKCYY YDYAKIIGES ESKYKLLGLN LLYLLSGNRV 120
  121 SDFHTELELL SVDVIQHNQF IRPILALEQY IMEGRYNKIF QAKSTVPVEV YSYFMDLLLE 180
  181 TVRDEIGACI EKSYDKISAK DAAKRLNLRV PDEIKAFGAK RQWKLEASGD YSFTDRSVKP 240
  241 KELLPSEELA EQVLSYARDL EMIV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..264] FFAS03 2.08 Crystal Structure of Human eIF3k

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.76236644111948 bayes_pls_golite062009
  • hydrolase activity
    		•  2.62777210765927 bayes_pls_golite062009
  • protein binding
    		•  1.5114863464349 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.48815906385664 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.08079130332447 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.06350696248374 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.700922242779288 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.37240198519167 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.224432853777564 bayes_pls_golite062009
  • DNA binding
    		•  0.180353635969032 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.147335771550418 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.142921675412538 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.124542865343065 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle