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Protein Overview: FBpp0309765, robo-PA

General Information:
Name(s) found: FBpp0309765 [FlyBase]
robo-PA / FBpp0071833 [FlyBase]
Description(s) found:
Found 27 descriptions.
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  • type=protein; loc=2R:complement(18582058..18582817,18582893..18583224,18583282..18583514,18583577..18583868,18583924..18584198,18584257..18584455,18584520..18584612,18584671..18584841,18584907..18584988,18585050..18585210,18585277..18585359,18585417..18585896,18585957..18586410,18586471..18586589,18586701..18586881,18587118..18587239,18587307..18587457); ID=FBpp0309765; name=robo-PC; parent=FBgn0005631,FBtr0343013; dbxref=FlyBase:FBpp0309765,FlyBase_Annotation_IDs:CG13521-PC; MD5=8d69b38f9dac0ab818243a26918d41c7; length=1395; release=r5.56; species=Dmel; [FlyBase]
  • The gene roundabout is referred to in FlyBase by the symbol Dmel\robo (CG13521, FBgn0005631). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:18580029..18588467. It has the cytological map location 59A2-59A3. There is experimental evidence that it has the molecular function</span>: heparin binding; protein binding. There is experimental evidence for 11 unique biological process</span> terms, many of which group under: anatomical structure development; cellular component movement; cell projection organization; regulation of biological process; organ morphogenesis; organ development; neuron differentiation; neuromuscular process; locomotory behavior; response to external stimulus; entrainment of circadian clock. 41 alleles are reported. The phenotypes of these alleles are annotated with 44 unique terms, many of which group under: embryonic nervous system; multi-cell-component structure; nervous system; embryonic neuron; organ system; commissure; abdominal transverse muscle; peripheral nervous system; organ system subdivision; antennal segment. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1395 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [ISS]
    dendrite [IDA]
    vesicle [IDA]
    neuronal cell body [IDA]
    protein complex [IPI]
    plasma membrane [IDA]
    axon [IDA]
    Biological Process: positive regulation of cell-cell adhesion [IMP]
    neuron recognition [IMP]
    salivary gland boundary specification [IMP]
    axon guidance [IMP][TAS]
    brain morphogenesis [IGI]
    embryonic heart tube development [IMP]
    dendrite morphogenesis [TAS]
    epithelial cell migration, open tracheal system [TAS]
    locomotion involved in locomotory behavior [IMP]
    entrainment of circadian clock [IDA]
    startle response [IMP]
    axon midline choice point recognition [IMP][TAS]
    dendrite guidance [IMP]
    Molecular Function: protein binding [IPI]
    heparin binding [IDA]
    receptor activity [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHPMHPENHA IARSTSTTNN PSRSRSSRMW LLPAWLLLVL VASNGLPAVR GQYQSPRIIE  60
   61 HPTDLVVKKN EPATLNCKVE GKPEPTIEWF KDGEPVSTNE KKSHRVQFKD GALFFYRTMQ 120
  121 GKKEQDGGEY WCVAKNRVGQ AVSRHASLQI AVLRDDFRVE PKDTRVAKGE TALLECGPPK 180
  181 GIPEPTLIWI KDGVPLDDLK AMSFGASSRV RIVDGGNLLI SNVEPIDEGN YKCIAQNLVG 240
  241 TRESSYAKLI VQVKPYFMKE PKDQVMLYGQ TATFHCSVGG DPPPKVLWKK EEGNIPVSRA 300
  301 RILHDEKSLE ISNITPTDEG TYVCEAHNNV GQISARASLI VHAPPNFTKR PSNKKVGLNG 360
  361 VVQLPCMASG NPPPSVFWTK EGVSTLMFPN SSHGRQHVAA DGTLQITDVR QEDEGYYVCS 420
  421 AFSVVDSSTV RVFLQVSSLD ERPPPIIQIG PANQTLPKGS VATLPCRATG NPSPRIKWFH 480
  481 DGHAVQAGNR YSIIQGSSLR VDDLQLSDSG TYTCTASGER GETSWAATLT VEKPGSTSLH 540
  541 RAADPSTYPA PPGTPKVLNV SRTSISLRWA KSQEKPGAVG PIIGYTVEYF SPDLQTGWIV 600
  601 AAQRVGDTQV TISGLTPGTS YVFLVRAENT QGISVPSGLS NTIKTIEADF DAASANDLSA 660
  661 ARTLLTGKSV ELIDASAINA SAVRLEWMLH VSADEKYVEG LRIHYKDASV PSAQYHSITV 720
  721 MDASAESFVV GNLKKYTKYE FFLTPFFETI EGQPSNSKTA LTYEDVPSAP PDNIQIGMYN 780
  781 QTAGWVRWTP PPSQHHNGNL YGYKIEVSAG NTMKVLANMT LNATTTSVLL NNLTTGAVYS 840
  841 VRLNSFTKAG DGPYSKPISL FMDPTHHVHP PRAHPSGTHD GRHEGQDLTY HNNGNIPPGD 900
  901 INPTTHKKTT DYLSGPWLMV LVCIVLLVLV ISAAISMVYF KRKHQMTKEL GHLSVVSDNE 960
  961 ITALNINSKE SLWIDHHRGW RTADTDKDSG LSESKLLSHV NSSQSNYNNS DGGTDYAEVD1020
 1021 TRNLTTFYNC RKSPDNPTPY ATTMIIGTSS SETCTKTTSI SADKDSGTHS PYSDAFAGQV1080
 1081 PAVPVVKSNY LQYPVEPINW SEFLPPPPEH PPPSSTYGYA QGSPESSRKS SKSAGSGIST1140
 1141 NQSILNASIH SSSSGGFSAW GVSPQYAVAC PPENVYSNPL SAVAGGTQNR YQITPTNQHP1200
 1201 PQLPAYFATT GPGGAVPPNH LPFATQRHAA SEYQAGLNAA RCAQSRACNS CDALATPSPM1260
 1261 QPPPPVPVPE GWYQPVHPNS HPMHPTSSNH QIYQCSSECS DHSRSSQSHK RQLQLEEHGS1320
 1321 SAKQRGGHHR RRAPVVQPCM ESENENMLAE YEQRQYTSDC CNSSREGDTC SCSEGSCLYA1380
 1381 EAGEPAPRQM TAKNT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..152] PSI-BLAST 43.221849 No description for 2v9qA was found.
    2 View Details [153..543] PSI-BLAST 40.30103 Hemolin
    3 View Details [544..635] PSI-BLAST 41.39794 No description for 2nziA was found.
    4 View Details [636..1171] PSI-BLAST 10.69897 No description for 1zlgA was found.
    5 View Details [1172..1269] deduced N/A No confident structure predictions are available.
    6 View Details [1270..1395] MSA 6.144995 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • telethonin binding
    		•  6.64811984458494 bayes_pls_golite062009
  • alpha-actinin binding
    		•  5.77350124471385 bayes_pls_golite062009
  • actinin binding
    		•  5.69539760434923 bayes_pls_golite062009
  • structural constituent of muscle
    		•  4.93896503565413 bayes_pls_golite062009
  • binding
    		•  3.17641566810715 bayes_pls_golite062009
  • receptor activity
    		•  2.6260148704617 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.26083981067854 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.26075587783872 bayes_pls_golite062009
  • signal transducer activity
    		•  2.26075587783872 bayes_pls_golite062009
  • protein binding
    		•  2.22855404705168 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  1.8360014271135 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  1.70428381075539 bayes_pls_golite062009
  • antigen binding
    		•  1.63189745559168 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.58610597245454 bayes_pls_golite062009
  • actin binding
    		•  1.42681407553255 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  1.36789541796983 bayes_pls_golite062009
  • protein kinase activity
    		•  1.36635494500222 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.32330470851159 bayes_pls_golite062009
  • DNA binding
    		•  1.19412627500732 bayes_pls_golite062009
  • myosin light chain kinase activity
    		•  1.17845072849922 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.16252234499274 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.02286631988334 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  0.955166176899348 bayes_pls_golite062009
  • kinase activity
    		•  0.929878054374821 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.878595022643164 bayes_pls_golite062009
  • olfactory receptor activity
    		•  0.76374091031142 bayes_pls_golite062009
  • actin filament binding
    		•  0.760856470721016 bayes_pls_golite062009
  • peptide antigen binding
    		•  0.75156669330877 bayes_pls_golite062009
  • IgG binding
    		•  0.68435857661103 bayes_pls_golite062009
  • myosin heavy chain binding
    		•  0.66378995104464 bayes_pls_golite062009
  • receptor binding
    		•  0.632627479346393 bayes_pls_golite062009
  • titin binding
    		•  0.599892148302011 bayes_pls_golite062009
  • integrin binding
    		•  0.599569390248921 bayes_pls_golite062009
  • structural molecule activity
    		•  0.567620977360967 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.564762108830441 bayes_pls_golite062009
  • transcription factor activity
    		•  0.54549168007511 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  0.51084773288725 bayes_pls_golite062009
  • protein complex binding
    		•  0.43131084085213 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.318890055375093 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.310661919610704 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0579247757286607 bayes_pls_golite062009
  • transferase activity
    		•  0.053007146193305 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.0182656128082201 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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