Protein Overview: pAbp-PB, pAbp-PA...

General Information:
Name(s) found:	pAbp-PB / FBpp0085919 [FlyBase] pAbp-PA / FBpp0085917 [FlyBase] pAbp-PC / FBpp0085915 [FlyBase]
Description(s) found: Found 97 descriptions. SHOW ALL	The gene polyA-binding protein is referred to in FlyBase by the symbol Dmel\pAbp (CG5119, FBgn0003031). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:14027583..14033740. It has the cytological map location 55B8-55B9. There is experimental evidence that it has the molecular function</span>: protein binding; mRNA 3'-UTR binding. There is experimental evidence that it is involved in the biological process</span>: synaptic transmission; dorsal/ventral pattern formation; positive regulation of translation; oogenesis. 12 alleles are reported. The phenotypes of these alleles are annotated with: meiotic metaphase I; bouton; neuromuscular junction; larval neuromuscular junction; wing; meiotic cell cycle. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase] The gene polyA-binding protein is referred to in FlyBase by the symbol Dmel\pAbp (CG5119, FBgn0003031). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:14027583..14033740. It has the cytological map location 55B8-55B9. There is experimental evidence that it has the molecular function</span>: protein binding; mRNA 3'-UTR binding. There is experimental evidence that it is involved in the biological process</span>: synaptic transmission; dorsal/ventral pattern formation; positive regulation of translation; oogenesis. 12 alleles are reported. The phenotypes of these alleles are annotated with: meiotic metaphase I; bouton; neuromuscular junction; larval neuromuscular junction; wing; meiotic cell cycle. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase] The gene polyA-binding protein is referred to in FlyBase by the symbol Dmel\pAbp (CG5119, FBgn0003031). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:14027583..14033740. It has the cytological map location 55B8-55B9. There is experimental evidence that it has the molecular function</span>: protein binding; mRNA 3'-UTR binding. There is experimental evidence that it is involved in the biological process</span>: synaptic transmission; dorsal/ventral pattern formation; positive regulation of translation; oogenesis. 12 alleles are reported. The phenotypes of these alleles are annotated with: meiotic metaphase I; bouton; neuromuscular junction; larval neuromuscular junction; wing; meiotic cell cycle. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	634 amino acids
Gene Ontology:
Cellular Component:	lipid particle [IDA] ribonucleoprotein complex [IDA] catalytic step 2 spliceosome [IDA] cytoplasm [IDA] precatalytic spliceosome [IDA]
Biological Process:	positive regulation of translation [IGI][TAS] oogenesis [IMP] male meiosis [IMP] synaptic transmission [IMP] dorsal/ventral pattern formation [IMP] nuclear mRNA splicing, via spliceosome [IC]
Molecular Function:	nucleotide binding [IEA] protein binding [IPI] poly(A) RNA binding [ISS][NAS][TAS] mRNA binding [ISS] mRNA 3'-UTR binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASLYVGDLP QDVNESGLFD KFSSAGPVLS IRVCRDVITR RSLGYAYVNF QQPADAERAL  60
   61 DTMNFDLVRN KPIRIMWSQR DPSLRRSGVG NVFIKNLDRA IDNKAIYDTF SAFGNILSCK 120
  121 VATDEKGNSK GYGFVHFETE EAANTSIDKV NGMLLNGKKV YVGKFIPRKE REKELGEKAK 180
  181 LFTNVYVKNF TEDFDDEKLK EFFEPYGKIT SYKVMSKEDG KSKGFGFVAF ETTEAAEAAV 240
  241 QALNGKDMGE GKSLYVARAQ KKAERQQELK RKFEELKQKR HESVFGVNLY VKNLDDTIDD 300
  301 DRLRIAFSPY GNITSAKVMT DEEGRSKGFG FVCFNAASEA TCAVTELNGR VVGSKPLYVA 360
  361 LAQRKEERKA HLASQYMRHM TGMRMQQLGQ IYQPNAASGF FVPTLPSNQR FFGSQVATQM 420
  421 RNTPRWVPQV RPPAAIQGVQ AGAAAAGGFQ GTAGAVPTQF RSAAAGARGA QPQVQGTHAA 480
  481 AAAANNMRNT GARAITGQQT AAPNMQIPGA QIAGGAQQRT SNYKYTSNMR NPPVPQLHQT 540
  541 QPIPQQLQGK NSEKLIASLL ANAKPQEQKQ ILGERLYPMI EHMHANLAGK ITGMLLEIEN 600
  601 SELLHMIEDQ EALKAKVEEA VAVLQVHRVT EPAN

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
RNA binding	6.73097473547076	bayes_pls_golite062009
mRNA binding	5.29759606920196	bayes_pls_golite062009
nucleic acid binding	4.92126426323641	bayes_pls_golite062009
	4.45006565905155	bayes_pls_golite062009
binding	3.64400841800969	bayes_pls_golite062009
single-stranded RNA binding	2.93798024346416	bayes_pls_golite062009
poly-pyrimidine tract binding	2.79052809544187	bayes_pls_golite062009
structural molecule activity	2.78501986457503	bayes_pls_golite062009
poly(U) RNA binding	2.49013736906028	bayes_pls_golite062009
transcription regulator activity	2.18211199677674	bayes_pls_golite062009
protein binding	2.17260848225967	bayes_pls_golite062009
DNA binding	1.98418556946403	bayes_pls_golite062009
hydrolase activity	1.59923957614061	bayes_pls_golite062009
snRNA binding	1.44241647066188	bayes_pls_golite062009
transcription factor activity	1.07843408116687	bayes_pls_golite062009
transcription repressor activity	1.06887262556449	bayes_pls_golite062009
transcription activator activity	1.02778561397221	bayes_pls_golite062009
mRNA 3'-UTR binding	0.824614388276642	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.632534695085793	bayes_pls_golite062009
eukaryotic initiation factor 4G binding	0.597542453741953	bayes_pls_golite062009
sequence-specific DNA binding	0.383589644462932	bayes_pls_golite062009
translation regulator activity	0.38120065819101	bayes_pls_golite062009
U1 snRNA binding	0.290135317640781	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.128616879457381	bayes_pls_golite062009

No functions predicted.

Term	Confidence	Notes
RNA binding	6.32219487559982	bayes_pls_golite062009
mRNA binding	4.87640532914983	bayes_pls_golite062009
nucleic acid binding	4.65259034341669	bayes_pls_golite062009
	4.22120207254226	bayes_pls_golite062009
binding	3.48033873254013	bayes_pls_golite062009
structural molecule activity	2.79390010162962	bayes_pls_golite062009
single-stranded RNA binding	2.55628738360472	bayes_pls_golite062009
poly-pyrimidine tract binding	2.38400992482878	bayes_pls_golite062009
transcription regulator activity	2.2045206027152	bayes_pls_golite062009
poly(U) RNA binding	2.13305841145089	bayes_pls_golite062009
protein binding	2.10850948869511	bayes_pls_golite062009
DNA binding	1.99030664201171	bayes_pls_golite062009
hydrolase activity	1.62800695894716	bayes_pls_golite062009
snRNA binding	1.15643072278378	bayes_pls_golite062009
transcription factor activity	1.09958329302628	bayes_pls_golite062009
transcription repressor activity	1.07516027015942	bayes_pls_golite062009
transcription activator activity	1.03081648377979	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.633093884585572	bayes_pls_golite062009
eukaryotic initiation factor 4G binding	0.468183942177665	bayes_pls_golite062009
mRNA 3'-UTR binding	0.462558743683805	bayes_pls_golite062009
sequence-specific DNA binding	0.327072171076297	bayes_pls_golite062009
translation regulator activity	0.246220338604608	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.0127733116412899	bayes_pls_golite062009
U1 snRNA binding	0.00409932271658597	bayes_pls_golite062009

No functions predicted.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..168]	PSI-BLAST	55.39794	Poly(A)-binding protein
2	View Details	[169..282]	PSI-BLAST	17.0	No description for 2d9pA was found.
3	View Details	[283..406]	FFAS03	4.49	CBP20, 20KDa nuclear cap-binding protein
4	View Details	[407..563]	PSI-BLAST	4.39794	Sec24
5	View Details	[564..634]	PSI-BLAST	30.0	poly(A) binding protein

Protein Overview: pAbp-PB, pAbp-PA...

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: