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Protein Overview: FBpp0304259, Alk-PA

General Information:
Name(s) found: FBpp0304259 [FlyBase]
Alk-PA / FBpp0086264 [FlyBase]
Description(s) found:
Found 29 descriptions.
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  • type=protein; loc=2R:complement(12516578..12518093,12518157..12518364,12518424..12519457,12519524..12519701,12519768..12519955,12520023..12520515,12520586..12521279,12521364..12522158); ID=FBpp0304259; name=Alk-PB; parent=FBgn0040505,FBtr0331926; dbxref=FlyBase:FBpp0304259,FlyBase_Annotation_IDs:CG8250-PB,REFSEQ:NP_001261027,GB_protein:AGB93559; MD5=f3cbc013c80a101afc5eb2e225e10cf2; length=1701; release=r5.56; species=Dmel; [FlyBase]
  • The gene Alk is referred to in FlyBase by the symbol Dmel\Alk (CG8250, FBgn0040505). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12513590..12525279. It has the cytological map location 53C12-53C13. Based on sequence similarity, it is predicted to have molecular function</span>: transmembrane receptor protein tyrosine kinase activity. There is experimental evidence that it is involved in the biological process</span>: visceral muscle development; gut development; activation of MAPKK activity; axon guidance; compound eye photoreceptor development; regulation of hemocyte differentiation; mesoderm development. 26 alleles are reported. The phenotypes of these alleles are annotated with: lamellocyte; visceral mesoderm; embryonic somatic muscle; larval digestive system; hemocyte; embryonic visceral muscle; larval midgut. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1701 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [ISS]
    Biological Process: activation of MAPKK activity [IMP]
    compound eye photoreceptor development [IMP]
    gut development [IMP]
    regulation of hemocyte differentiation [IMP]
    mesoderm development [IMP]
    transmembrane receptor protein tyrosine kinase signaling pathway [IEA]
    axon guidance [IMP]
    protein amino acid phosphorylation [NAS]
    visceral muscle development [IMP]
    Molecular Function: ATP binding [IEA]
    protein tyrosine kinase activity [NAS]
    protein binding [IEA]
    transmembrane receptor protein tyrosine kinase activity [ISS]
    receptor signaling protein tyrosine kinase activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPQLRQLVVV LAILSLLVDP SFAQRPLIMN HTFSSLPMSQ HPSFNSWPSA SGGKQLRNGR  60
   61 LHEQPLPLPQ PTLPVATQYE DYEAAPPGSR RDNKRRLAQM AQRPGSGNGG RRGMESLRKE 120
  121 LMNPSVGGPG GGISGGGSGY PSYSATSSIG RIDGLGQGLG SADRYGALYD QLRQPSGMAA 180
  181 MTAGPLGGPY STRFPPLYAG VDDQPKRSNR KNSISELYKL KKALNQADEP AGGVTHGNFE 240
  241 GDPQPSSADP LQEIKDRIRD TSPNANTYAP HTDATPSSEY EYELGVKCNF ETPCSWTWGN 300
  301 YSDGFQVITG TELSKRNLTG LLPGPAADSI DDANGHFLYA RVNPSSRPLN LTSPEFSTTM 360
  361 EKCFLEVYMH QSDMSHGLSR VVVELLHTAE SSWVPAEILG DNVRQWTRKV YRLGRVSRDF 420
  421 RIVFEVVPDL RVGQKGHVAL DNLRMVNCFP EGTKSEKCST SQVKCTSSKV PVCIHLPRIC 480
  481 DITRDCDEAE DEQQSCDKIP YGGRCDFEED WCGWRDSGKT TLTWSRHTGS SPTHDTGPDG 540
  541 DHTMQHLQNN TSGYYMLVNM NQHMNNSEKN SIIGFASNAI MVSKTFNPPP SVHGNPDSPY 600
  601 RNSCVVRFFI HQFGKNPGSI NLSVVEMKEK ENITTTLWWS TKNQGSDWMR AEYVLPNITS 660
  661 KYYLQFEARM GMRIYSDVAV DDFSLSPECF GLNIPEDHLG GYNYWDVRQN LKSPTYKDFE 720
  721 YTNYLELTTC DTRGMIGPSQ AQCEAAYREQ NKTHVLREVH VVEDQSSYKG MQKWKVPHEG 780
  781 HYTIIAKGAS GGLGSGGVGS SRGSVAVAIL ELHKNEELYF LVGQQGENAC IKSMGVLKEA 840
  841 GCGTDHDLDL AQYSFRSKQD MVKNIYIENG AGGGGGGSYV FLLNQAKNEA VPLLVAGGGG 900
  901 GLGIGQYIDE DFQHGQKAKP LQAPESGQIN GEPLNKKTAG PGGGWRAKED QALSPTYGAA 960
  961 LLQGGRGGHS CYVELADNGT SVHRHGQGGF GGGGGGCNTG GGGGGYAGGD VYLTESNGEG1020
 1021 GSSYISPSRS LREISEIHAG ASSGPGAIII IPAIEGCGCD YRCVALDEFR SKVRCICPDG1080
 1081 WSLKRDNHTA CEIREEAGKS SFQYLVSILM ISLAVLFICI AALIFMLYNR YQRKKQSKKR1140
 1141 HKMLVEQDLQ LTRLRNNIDD SNLNNFNPNY GCDGILNGHI DVNSLPQVAR DSLQLVNALG1200
 1201 KGAFGEVYMA LYRHRDGDAV EMGVAVKTLR EDPKREKEED FLKEAAIMAK FNHPNMVHLI1260
 1261 GVCFDRQPYY IVLELLAGGD LQKFLRENRN TPERPSLLTM KDLLFCALDV AKGCRYMESK1320
 1321 RFIHRDIAAR NCLLSSKGPG RVVKIADFGM SRDIYRSDYY RKGGKAMLPI KWMPPEAFLD1380
 1381 GIFTSKTDVW SFGILLWEVF SLGRSPYPGQ HNTQVMELVV RGGRLGSPTE CPVSIYKVMA1440
 1441 DCWNPTPEDR PTFITLLEHL TACTQDASIM NAPLPNILGP TASERDDTVI RPPNGEEFCL1500
 1501 AVPDYLVPLP PGGSNNPSMA SGSGYVPELQ RQQMSSCTPP AVTSPAAPHP RPVENIAPTS1560
 1561 GDCWETSFIL PNSKVEPPVV GSGHDVPLAG GEEAKLISLD TPQPTPTTIQ PPLSFASQLD1620
 1621 GITLDPSALT KSLPNGNAKQ SYANVQVKNE AEAKVINGVV GNGTVMNGDV STGSGGADSP1680
 1681 FTIQGYAERY KDNNNHSEIS C

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..231] deduced N/A No confident structure predictions are available.
    2 View Details [232..538] PSI-BLAST 28.69897 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
    3 View Details [539..700] PSI-BLAST 19.69897 No description for 2v5yA was found.
    4 View Details [701..795] deduced N/A No confident structure predictions are available.
    5 View Details [796..935] PSI-BLAST 17.30103 Crystal Structure of the 3 Ig form of FGFR3c in complex with FGF1
    6 View Details [936..1477] PSI-BLAST 72.522879 No description for 2h8hA was found.
    7 View Details [1478..1559] PSI-BLAST 77.221849 No description for 2qoqA was found.
    8 View Details [1560..1701] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.04467222534257 bayes_pls_golite062009
  • kinase activity
    		•  4.85903980916957 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.63692708178478 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  4.09909681656699 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  3.41480681854114 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • transferase activity
    		•  3.26787750561728 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.1965684217331 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  2.9751846707539 bayes_pls_golite062009
  • receptor activity
    		•  2.96273889901429 bayes_pls_golite062009
  • signal transducer activity
    		•  2.85730457922199 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.85730457922199 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  2.70917101514973 bayes_pls_golite062009
  • growth factor binding
    		•  2.61235080252818 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  1.9011085456623 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.82515074380651 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.81145713371725 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine kinase activity
    		•  1.66669268613198 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • vinculin binding
    		•  1.63216315345235 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.59474164216385 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  1.51779793980227 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  1.51779793980227 bayes_pls_golite062009
  • integrin binding
    		•  1.44154155381408 bayes_pls_golite062009
  • kinase binding
    		•  1.26086833316556 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • protein kinase binding
    		•  1.06030596516506 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  0.95914323793919 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • transporter activity
    		•  0.710766490066447 bayes_pls_golite062009
  • actin filament binding
    		•  0.66248865719696 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.655396214040669 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.631882811427766 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.610230065465794 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.60324822483033 bayes_pls_golite062009
  • DNA binding
    		•  0.599969415455862 bayes_pls_golite062009
  • activin binding
    		•  0.510364757301021 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • transcription factor activity
    		•  0.457173041568166 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.385603245903806 bayes_pls_golite062009
  • insulin receptor activity
    		•  0.359260732334699 bayes_pls_golite062009
  • JUN kinase kinase kinase kinase activity
    		•  0.349343975617553 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  0.294256794094724 bayes_pls_golite062009
  • transforming growth factor beta binding
    		•  0.287757704969289 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.233896787419349 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.229808864843639 bayes_pls_golite062009
  • cytokine binding
    		•  0.17817111033393 bayes_pls_golite062009
  • activin receptor activity
    		•  0.163693280420599 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.152203945257581 bayes_pls_golite062009
    7 No functions predicted.
    8 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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