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Protein Overview: FBpp0292050

General Information:
Name(s) found: FBpp0292050 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • type=protein; loc=2R:complement(12131437..12131587,12131654..12131804,12132000..12132665,12133878..12134417,12135252..12135414,12135732..12135983,12137036..12137110); ID=FBpp0292050; name=CngA-PA; parent=FBgn0261612,FBtr0302924; dbxref=FlyBase_Annotation_IDs:CG7779-PA,FlyBase:FBpp0086331,FlyBase:FBpp0292050,FlyBase_Annotation_IDs:CG42701-PA,REFSEQ:NP_477116,GB_protein:AAF58033,FlyMine:FBpp0292050,modMine:FBpp0292050; MD5=88a34c4c3b9320f5941c4ee73c50611a; length=665; release=r5.56; species=Dmel; [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 665 amino acids

    Gene Ontology:
    Cellular Component: intracellular cyclic nucleotide activated cation channel complex [NAS]
    membrane [IEA]
    Biological Process: cGMP-mediated signaling [TAS]
    ion transport [IEA]
    cation transport [NAS]
    transmembrane transport [IEA]
    Molecular Function: intracellular cyclic nucleotide activated cation channel activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRHFKVKAMV QSLDISAITG QQTDAEPSKR SKPSALRRTL QALRQRLTKR NRPKPPDWFL  60
   61 EKFSNTTNTD KIGKGCPAME DAALSSEIRG SSVLCNRLSV DPTLQSHYRW LAIVSLAVLY 120
  121 NIIFVVGRAV FWEINKSAPA FWYTLDYLCD FIYLLDTLVH MHEGFLDQGL LVRDAFRLRR 180
  181 HYFHTKGWYL DVLSMLPTDL AYIWWPPETC SSLYLPCPVI VRLNRLLRIN RLWEWFDRTE 240
  241 TATGYPNAFR ICKVVLAILV LIHWNACMYF AISYEIGFSS DSWVYNLNGT RNNTLQRQYI 300
  301 YSFYWSTLTL TTIGETPTPE NDVEYLFVVA DFLAGVLIFA TIVGNIGSMI SNMNVARVEF 360
  361 QNRMDGVKQY MAFRRVGHEL EARVIRWFAY TWSQSGALDE ERVLAALPDK LKAEIAIQVH 420
  421 MDTLKQVRIF HDTEPGLLEA LVLKLKLQVF SPGDYICRKG DVGKEMYIVK RGKLSVVGDD 480
  481 GITVLATLGA GSVFGEVSVL EIAGNRTGNR RTANVRSLGY SDLFCLAKRD LWETLSDYPE 540
  541 ARSTLTQRGC QLLRKDGLLD EQIFADSQRV HDSIEGGIEK LELSVENLNM RLARLLAEYT 600
  601 ASQAKIKQRL AKLEMNGGPG TWRLECEPQS RARSGRLYSL QPKRRPRSRP DATAKSSDAA 660
  661 KQNTL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..374] PSI-BLAST 41.69897 Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
    2 View Details [375..566] PSI-BLAST 15.69897 HCN2J 443-645 in the presence of cGMP
    3 View Details [567..665] PSI-BLAST 18.522879 Catabolite gene activator protein (CAP), C-terminal domain; Catabolite gene activator protein, N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • cyclic nucleotide-gated ion channel activity
    		•  10.1422916734545 bayes_pls_golite062009
  • intracellular cyclic nucleotide activated cation channel activity
    		•  10.1422916734545 bayes_pls_golite062009
  • intracellular ligand-gated ion channel activity
    		•  9.72053268940283 bayes_pls_golite062009
  • cation channel activity
    		•  9.48749374439976 bayes_pls_golite062009
  • ion channel activity
    		•  9.4846197809463 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  9.3929063879608 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  9.25176207085973 bayes_pls_golite062009
  • channel activity
    		•  9.25176207085973 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  9.2472549851376 bayes_pls_golite062009
  • intracellular cGMP activated cation channel activity
    		•  9.19973076787954 bayes_pls_golite062009
  • gated channel activity
    		•  9.19042473454294 bayes_pls_golite062009
  • cGMP binding
    		•  7.7575871125398 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  7.41584542512987 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  7.41584542512987 bayes_pls_golite062009
  • cyclic nucleotide binding
    		•  7.37322432929433 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  6.57272328088253 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  6.54930851487319 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  5.54400173845933 bayes_pls_golite062009
  • GMP binding
    		•  5.49455172024846 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  5.34760703274696 bayes_pls_golite062009
  • potassium channel activity
    		•  5.29889968906368 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  5.1138025954757 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  4.96516802098805 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  4.52895684111035 bayes_pls_golite062009
  • intracellular cAMP activated cation channel activity
    		•  3.95109938608832 bayes_pls_golite062009
  • transporter activity
    		•  3.30740141256752 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.24402760485462 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.22443361822344 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.7487659479534 bayes_pls_golite062009
  • signal transducer activity
    		•  1.7487659479534 bayes_pls_golite062009
  • binding
    		•  1.59096092728475 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.40720858109605 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.930640481652164 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.910527807644534 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.848189810874263 bayes_pls_golite062009
  • protein binding
    		•  0.81302068072988 bayes_pls_golite062009
    3
    Term Confidence Notes
  • binding
    		•  2.88885372623841 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.7317847461735 bayes_pls_golite062009
  • DNA binding
    		•  2.48559849769138 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.38705965090247 bayes_pls_golite062009
  • transcription factor activity
    		•  1.86553483886232 bayes_pls_golite062009
  • signal transducer activity
    		•  1.42015496657117 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.42015496657117 bayes_pls_golite062009
  • protein binding
    		•  0.753698599635855 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.57001406505152 bayes_pls_golite062009
  • transcription activator activity
    		•  0.376344018138683 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.296777088118869 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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